1. Diterpenoid glucosides with anti-inflammatory activity from Sigesbeckia glabrescens.
- Author
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Tang, Lian-Yu, Zhang, Ya-Zhao, Gao, Yun, Tsering, Tashi, Jia, Jingming, and Wang, Anhua
- Subjects
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PLANT anatomy , *MACROPHAGES , *NITRIC oxide , *TERPENES , *PLANT extracts , *ANTI-infective agents , *MEDICINAL plants , *GLYCOSIDES , *LIPOPOLYSACCHARIDES , *SPECTRUM analysis , *INFLAMMATION , *PHARMACODYNAMICS - Abstract
Six previously undescribed diterpenoid glucosides, along with four known compounds, were isolated from the aerial parts of Sigesbeckia glabrescens. The structures and absolute configurations of undescribed compounds were elucidated using extensive spectroscopic techniques, ECD calculations and chemical methods. Compounds 1 and 8 exhibited anti-inflammatory activity against LPS-induced NO production in RAW 264.7 macrophages, with compound 8 demonstrating significant inhibitory activity compared to positive control minocycline, boasting an IC 50 value at 14.20 μM. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2024
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