1. Cell-in-cell phenomenon associates with aggressive characteristics and cancer-related mortality in early oral tongue cancer.
- Author
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Almangush, Alhadi, Mäkitie, Antti A., Hagström, Jaana, Haglund, Caj, Kowalski, Luiz Paulo, Nieminen, Pentti, Coletta, Ricardo D., Salo, Tuula, and Leivo, Ilmo
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CANCER-related mortality , *TONGUE cancer , *ORAL cancer , *TUMOR budding , *GLOSSECTOMY , *SQUAMOUS cell carcinoma , *IMPACT craters , *RESEARCH , *CANCER invasiveness , *RESEARCH methodology , *CELL physiology , *PROGNOSIS , *MEDICAL cooperation , *EVALUATION research , *TUMOR classification , *COMPARATIVE studies , *KAPLAN-Meier estimator , *IMPACT of Event Scale , *PROPORTIONAL hazards models , *LONGITUDINAL method ,TONGUE tumors - Abstract
Background: Cell-in-cell structures (caused by cell cannibalistic activity) have been related to prognosis of many cancers. This is the first multi-institutional study to assess the prognostic impact of cell-in-cell structures in a large cohort of early oral tongue squamous cell carcinomas (OTSCC).Methods: A total of 308 cases from five Finnish University Hospitals and from the A.C. Camargo Cancer Center, São Paulo, Brazil, were included in this study. Cell-in-cell structures were evaluated on surgical postoperative sections that stained with hematoxylin and eosin staining.Results: We found that cell-in-cell structures associated with cancer-related mortality in univariable analysis with a hazard ratio (HR) of 2.99 (95%CI 1.52-5.88; P = 0.001). This association was confirmed in multivariable analysis (HR 2.22, 95%CI 1.12-4.44; P = 0.024). In addition, statistically significant associations were observed between the cell-in-cell structures and other adverse histopathologic characteristics including deep invasion (P < 0.001), high index of tumor budding (P = 0.007), worst pattern of invasion (P < 0.001), perineural invasion (P = 0.01), and stroma-rich pattern (P = 0.001).Conclusions: Our findings demonstrate a significant relationship between cell-in-cell formation and aggressive characteristics of early OTSCC. Cell-in-cell structures have a distinct impact as a novel prognostic indicator in early OTSCC and they can be easily assessed during routine pathology practice. [ABSTRACT FROM AUTHOR]- Published
- 2020
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