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1. Nocardioazines: A Novel Bridged Diketopiperazine Scaffold from a Marine-Derived Bacterium Inhibits P-Glycoprotein.

Author

Ritesh Raju, Andrew M. Piggott, Xiao-Cong Huang, and Robert J. Capon

Subjects
*PIPERAZINE, *P-glycoprotein, *MULTIDRUG resistance, *CANCER cells, *CHEMICAL inhibitors, *COLON cancer
Abstract

An Australian marine sediment-derived isolate, Nocardiopsissp. (CMB-M0232), yielded a new class of prenylated diketopiperazine, indicative of the action of a uniquely regioselective diketopiperazine indole prenyltransferase. The bridged scaffold of nocardioazine A proved to be a noncytotoxic inhibitor of the membrane protein efflux pump P-glycoprotein, reversing doxorubicin resistance in a multidrug resistant colon cancer cell. [ABSTRACT FROM AUTHOR]

Published
2011
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