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The present work illustrates the effective treatment of raw pulp and paper mill effluent using a model hybrid upflow anaerobic sludge blanket reactor (HUASBR). The physico-chemical and biological characteristics of wastewater were observed to be critical from the pollution potential aspect. The design features of model HUASBR had a respective total and effective working capacity of 7.5 and 6.5l, together with 25 cm depth of packing by polypropylene hexagonal inert material at the top of the reactor. Start-up of the reactor was carried out using an inoculum mixture containing rumen liquid of goat and cow dung slurry at an appropriate ratio of 3 : 1(v/v). Also, the reactor was effectively started up at the end of 36 days. Based on the performance of model HUASBR, under the respective variations of organic loading rates (OLRs) of 1, 2 and 4 kg COD m-3 d-1, the stepwise COD removals were found to be about 41, 69 and 87%. However, a hydraulic loading rate (HRT) of 20 h was appropriately maintained throughout the studies. [ABSTRACT FROM AUTHOR]