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1. A single amino acid change in hemagglutinin reduces the cross-reactivity of antiserum against an equine influenza vaccine strain.

Author

Nemoto, Manabu, Yamayoshi, Seiya, Bannai, Hiroshi, Tsujimura, Koji, Kokado, Hiroshi, Kawaoka, Yoshihiro, and Yamanaka, Takashi

Subjects
*EQUINE influenza, *HEMAGGLUTININ, *INFLUENZA vaccines, *IMMUNE serums, *AMINO acids, *VIRAL genetics
Abstract

Equine influenza virus is an important pathogen for the horse industry because of its economic impact, and vaccination is a key control measure. Our previous work suggested that a mutation at position 144 in the hemagglutinin of Florida sublineage clade 2 viruses reduces the cross-neutralizing activity of antiserum against a former vaccine strain. To confirm this suggestion, here, we generated viruses by reverse genetics. Antibody titers against the mutated viruses were one-tenth to one-sixteenth of those against the former vaccine strain. Our findings confirm that this single amino acid substitution reduces the cross-reactivity of antiserum against this former Japanese vaccine. [ABSTRACT FROM AUTHOR]

Published
2019
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