1. The efficacy of immune checkpoint inhibitors in rare tumors: A systematic review of published clinical trials.
- Author
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Guven, Deniz Can, Stephen, Bettzy, Sahin, Taha Koray, Cakir, Ibrahim Yahya, Erul, Enes, and Aksoy, Sercan
- Subjects
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IMMUNE checkpoint inhibitors , *EPITHELIAL tumors , *MERKEL cell carcinoma , *CLINICAL trials , *GERM cell tumors , *GESTATIONAL trophoblastic disease , *THYMUS tumors - Abstract
The immune checkpoint inhibitors (ICIs) entered treatment algorithms in most tumors. However, the data on the efficacy is limited in rare tumors with no phase III studies. We systemically reviewed the clinical trials evaluating the ICI efficacy in rare tumors and included a total of 47 clinical trials in this review. The ICIs demonstrated over 30% response rates in Merkel cell carcinoma and squamous cell carcinoma of the skin and became the standard of care. Additionally, the ICI efficacy was promising in thymic epithelial tumors and gestational trophoblastic neoplasia. In contrast, the ICI efficacy is limited in most sarcomas, germ cell tumors and low-grade neuroendocrine tumors. The ICI efficacy seemed to be improved with combinations targeting tumor microenvironment in sarcomas. The available evidence on ICI efficacy in rare tumors denote a need for better patient selection and novel combination strategies to improve outcomes. [Display omitted] • The developments with immunotherapy in rare tumors are relatively slow. • Immunotherapy has promising activity in MCC and skin SCC. • The efficacy is limited in most sarcoma types, germ cell tumors, and low-grade NETs. • The biomarker data is limited and unequivocal. • Studies focusing on novel combination strategies and biomarkers are urgently needed. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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