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Start Over Author "Schihada, Hannes" Publication Year Range Last 50 years Database Academic Search Index Publisher american association for the advancement of science

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1. Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain.

Author

Kowalski-Jahn, Maria, Schihada, Hannes, Turku, Ainoleena, Huber, Thomas, Sakmar, Thomas P., and Schulte, Gunnar

Subjects
*CATENINS, *TRANSFER RNA, *AMINO acids, *DETECTORS, *CELL receptors, *MEMBRANE proteins
Abstract

The article focuses on Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain. Topics include Frizzleds are G protein–coupled receptors containing an extracellular cysteine-rich domain (CRD) binding Wingless/Int-1 lipoglycoproteins (WNTs), and the role of WNT/FZD signaling in health and disease, our understanding of how WNT binding is translated into receptor activation and transmembrane signaling remains limited.

Published
2021
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