1. Leveraging biomaterials for enhancing T cell immunotherapy.
- Author
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Liao, Ziyan, Zhang, Wentao, Zheng, Hanqi, Wang, Yanfang, Yu, Jicheng, Li, Hongjun, and Gu, Zhen
- Subjects
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BIOMATERIALS , *GRAFT rejection , *IMMUNOTHERAPY , *CELLULAR therapy , *CYTOTOXIC T cells , *AUTOIMMUNE diseases , *T cells - Abstract
The dynamic roles of T cells in the immune system to recognize and destroy the infected or mutated cells render T cell therapy a prospective treatment for a variety of diseases including cancer, autoimmune diseases, and allograft rejection. However, the clinical applications of T cell therapy remain unsatisfactory due to the tedious manufacturing process, off-target cytotoxicity, poor cell persistence, and associated adverse effects. To this end, various biomaterials have been introduced to enhance T cell therapy by facilitating proliferation, enhancing local enrichment, prolonging retention, and alleviating side effects. This review highlights the design strategies of biomaterials developed for T cell expansion, enrichment, and delivery as well as their corresponding therapeutic effects. The prospects of biomaterials for enhancing T cell immunotherapy are also discussed in this review. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2022
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