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• Garcinia genus is a rich depository of bioactive compounds. • Phytochemistry and pharmacology of lesser-known Garcinia species are discussed. • Toxicity profile of Garcinia species are examined. The tropical plants of Garcinia (Clusiaceae family) have been extensively used in folk medicine apart from its limited use in the preparation of certain dishes. This paper aims to provide a comprehensive and updated report on the diverse range of phytochemicals, the traditional uses, the nutritional values, the major pharmacological attributes, and the toxicological findings of ten Garcinia plants of south-east Asia. This was achieved by compiling data from various scientific journals, and books available on electronic databases viz. Pub Med, Scopus, Web of Science, Science Direct, Google Scholar, and others, published within the time period of 2010-2020. A myriad of natural products are found in Garcinia sp. The major classes of biomolecules reported to be present in these plants include organic acids, xanthones, benzophenones, flavonoids, phloroglucinols, fatty acids, and terpenoids. The chemical structures of the phytoconstituents presented in this review are drawn using ChemDraw Professional 16.0. Additionally, the important pharmacological properties such as antioxidant, anticancer, anti-diabetic, anti-inflammatory, cardioprotective, neuroprotective, antimicrobial, and hepatoprotective activities along with the toxicological studies of the Garcinia sp., are discussed. Although a good amount of research has been conducted on Garcinia sp., however some of these species still remain unattended and are becoming endemic. Therefore, this comprehensive review sheds light on the phyto-pharmacological profile of ten known Garcinia sp. to pave a path towards explorating of their traditional uses, isolating new molecules, encouraging in-depth preclinical and clinical research to understand the mechanism of action, thereby help in the development of new drug candidates with lesser side-effects. In addition, measures must be taken to enhance the conservation of endangered Garcinia sp. [ABSTRACT FROM AUTHOR]

The application of natural products and supplements has expanded tremendously over the past few decades. Clinacanthus nutans (C. nutans), which is affiliated to the Acanthaceae family, has recently caught the interest of researchers from the countries of subtropical Asia due to its medicinal uses in alternative treatment for skin infection conditions due to insect bites, microorganism infections and cancer, as well as for health well-being. A number of bioactive compounds from this plant's extract, namely phenolic compounds, sulphur containing compounds, sulphur containing glycosides compounds, terpens-tripenoids, terpens-phytosterols and chlorophyll-related compounds possess high antioxidant activities. This literature search yielded about one hundred articles which were then further documented, including the valuable data and findings obtained from all accessible electronic searches and library databases. The promising pharmacological activities from C. nutans leaves extract, including antioxidant, anti-cancer, anti-viral, anti-bacterial, anti-fungal, anti-venom, analgesic and anti-nociceptive properties were meticulously dissected. Moreover, the authors also discuss a few of the pharmacological aspect of C. nutans leaves extracts against anti-hyperlipidemia, vasorelaxation and renoprotective activities, which are seldom available from the previously discussed review papers. From the aspect of toxicological studies, controversial findings have been reported in both in-vitro and in-vivo experiments. Thus, further investigations on their phytochemical compounds and their mode of action showing pharmacological activities are required to fully grasp both traditional usage and their suitability for future drugs development. Data related to therapeutic activity and the constituents of C. nutans leaves were searched by using the search engines Google scholar, PubMed, Scopus and Science Direct, and accepting literature reported between 2010 to present. On the whole, this review paper compiles all the available contemporary data from this subtropical herb on its phytochemistry and pharmacological activities with a view towards garnering further interest in exploring its use in cardiovascular and renal diseases. [ABSTRACT FROM AUTHOR]