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Triple-negative breast cancer (TNBC) is associated with poor clinical prognosis due to a lack of effective therapeutic options. The expression of B-cell lymphoma/leukemia 11A (BCL11A) has been indicated to correlate with TNBC carcinogenesis, though the precise mechanisms of BCL11A-induced tumorigenesis in TNBC remain unclear. Using data retrieved from The Cancer Genome Atlas (TCGA) database, the present study demonstrated that BCL11A expression was upregulated in TNBC, compared with other types of breast cancer. Furthermore, in a tissue microarray of 140 patients with breast cancer, an elevated BCL11A level was correlated with unfavorable overall survival (OS), and exogenous BCL11A-knockdown was subsequently verified to inhibit tumor growth and metastasis in TNBC. Notably, the same tissue microarray revealed that a favorable patient outcome was associated with high expression levels of BCL11A and androgen receptor (AR). Moreover, BCL11A-knockdown significantly inhibited the expression level of AR and further had an influence on proliferation, migration and invasion in TNBC cell lines. Collectively, the results of the current study indicate the function of BCL11A in TNBC progression, and provide new insights into the unique mechanism of BCL11A in AR regulation, emphasizing the significance of more research on BCL11A and AR regulation in TNBC molecular treatment. [ABSTRACT FROM AUTHOR]

Graphical abstract Highlights • Novel VO x -based films coated with SiO 2 superhydrophobic coating are prepared. • VO x /SiO 2 composite films have good thermochromic and self-cleaning properties. • SiO 2 superhydrophobic coating render VO x -based films self-cleaning property. • The original excellent thermochromic of VO x -based films have been retained. Abstract The practical application of VO 2 smart glass is usually restricted by poor thermochromic property and contaminant. In this study, the VO x /SiO 2 composite films were fabricated using magnetron sputtering and sol-gel preparations. Compared with VO x -based films, the VO x /SiO 2 composite films showed the superhydrophobic property, and its water contact angle was up to 165°. At the same time, the VO x /SiO 2 composite films retained the original excellent thermochromic property with solar regulation of 13.95%, luminous transmittance of 37.34% and the low phase transition temperature around 38℃. This study provided guidance for the combined application of VO 2 smart glass and superhydrophobic coating. [ABSTRACT FROM AUTHOR]