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This article introduces the specific practices of Nanjing University in conducting science popularization work in deep cooperation with the school under the background of the "double reduction" policy. The science popularization base has established the principles of promoting the spirit of scientists, deeply integrating science popularization activities with in-class education, and carrying students as the center. All science popularization education activities are designed based on these principles. Some experiences in resource opening, teacher supply, curriculum development and so on are summarized. [ABSTRACT FROM AUTHOR]

Objective To investigate the risk factors for the development of advanced liver fibrosis by analyzing the clinical features of patients with in nonalcoholic fatty liver disease （NAFLD) and advanced liver fibrosis, and to establish a nomogram model for predicting the risk of advanced liver fibrosis. Methods A retrospective analysis was performed for the clinical data of 406 NAFLD patients who attended The First Affiliated Hospital of Henan University of Chinese Medicine from January 2022 to October 2023, and according to whether liver stiffness measurement （LSM) measured by FibroScan was ≥11.0 kPa, the patients were divided into advanced liver fibrosis group with 65 patients and non-advanced liver fibrosis group with 341 patients. Related data were collected, including general information, laboratory markers, and medical history. The independent-samples t test was used for comparison of normally distributed continuous data between two groups, and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups； the chi-square test was used for comparison of categorical data between two groups. A multivariate Logistic regression analysis was used to identify independent risk factors, and a nomogram model was established based on these factors. The receiver operating characteristic （ROC) curve was used to evaluate the discriminatory ability of the nomogram model, and the calibration curve was used to evaluate its effectiveness. Results The univariate analysis showed that there were significant differences between the advanced liver fibrosis group and the non-advanced liver fibrosis group in age, controlled attenuation parameter （CAP), total bilirubin, direct bilirubin （DBil), indirect bilirubin, globin, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase （ALP), gamma-glutamyl transpeptidase （GGT), glucose, body mass index （BMI), and history of diabetes （all P<0.05). The multivariate Logistic regression analysis showed that CAP （odds ratio ［OR］=1.015, 95% confidence interval ［CI］：1.006—1.024, P=0.010), DBil （OR=1.345, 95%CI：1.139—1.590, P=0.001), ALP （OR=1.019, 95%CI：1.008—1.029, P=0.001), GGT （OR=1.004, 95%CI：1.000—1.008, P=0.035) and BMI （OR= 1.240, 95%CI：1.137—1.353, P=0.001) were independent risk factors for the development of advanced liver fibrosis in NAFLD. A nomogram model was established based on the results of the multivariate Logistic regression analysis. The ROC curve analysis showed that this nomogram model had an area under the ROC curve of 0.841（95%CI：0.791—0.891) in predicting the development of advanced liver fibrosis in the NAFLD population, and the calibration curve showed a good degree of fitting between the observed and predicted values for the development of advanced liver fibrosis. Conclusion Elevated levels of CAP, BMI, DBil, ALP, and GGT are independent risk factors for advanced liver fibrosis in NAFLD. The nomogram model established based on these factors has good predictive performance and a certain value in predicting advanced liver fibrosis. [ABSTRACT FROM AUTHOR]

In light of the complexity of failure mechanisms in rotating machinery and the significant differences in feature information, traditional diagnostic models often rely on prior knowledge, leading to low accuracy and poor adaptability. We propose a rotating machinery fault diagnosis method named "Randomized Quantization-Randomized LSTM Block Mapping Method-Stochastic Configuration Network" (RQ-RLBM-SCN). To address the challenges posed by limited feature information in failing machinery and insufficient training samples, we employ random quantization data augmentation to expand the original data samples from multiple sensors. This enhances the model's adaptability, accuracy and mitigating overfitting. Next, we employ a random LSTM block mapping method to extract features, solving the difficulty of extracting temporal data features in stochastic configuration network (SCN). Sub-sequently, we utilize a stochastic configuration network (SCN) for classification. SCN dynamically configures parameters without the need for backpropagation to update parameters, ensuring a proper learning rate while effectively avoiding issues such as gradient explosion or vanishing. Research results indicate that the RQ-RLBM-SCN method can accurately identify bearing and gear faults. In 10 repeated experiments, the average accuracy on the multi-sensor dataset for bearings and gears reaches 99.80% and 98.75% respectively which are higher than the original SCN, TSC-SCN, VMD-SCN, SVM and KNN fault diagnosis methods. This approach provides a dynamic method and diagnostic insight for establishing a health monitoring model for rotating machinery. [ABSTRACT FROM AUTHOR]

[Objective] The Objectives of this study are to estimate the effects of throughfall exclusion (drought) on the sap flow in a Populus deltoides plantations and to enhance our understanding of the response of poplar plantations to changes in global precipitation patterns. [Methods] The study was conducted from September 2018 to November 2020 in a 10-year old poplar plantation in Dongtai Forest Farm. There were three treatments in this study, including CK (control), D1 (30% throughfall exclusion）, and D2 (50% throughfall exclusion）. The sap flow density and environmental factors were continuously measured by thermal diffusion probe technology and the Micro Weather Monitoring System to evaluatethe response of the poplar plantation to environmental factors. [Results] (1) In three treatments, the annual variation of sap flow in poplar plantations showed a single peak, similar to the interannual variation of vapor pressure deficit and photosynthetic active radiation. The sap flow rate reached its peak in summer, and then gradually decreased over time. In the dormant period, the sap flow density approached zero. (2) In the drought treatment, the sap flow decreased with the increasing throughfall exclusion. The average sap flow density in the growth seasons of D1 and D2 were 39.61 and 31.85 g/ (m² s）, respectively, which were significantly reduced by 24% to 39% compared to the control (p＜0.05）. (3) The mixed effect model showed that the vapor pressure deficit and soil temperature were extremely significantly correlated with sap flow (p＜0.01）, while air temperature, rainfall, and soil temperature were significantly correlated with sap flow (p＜0.05）. [Conclusion] In D1 treatment, the power of explanation of environmental factors to sap flow increased, and the sensitivity sap flow to environmental changes could be increased in drought treatments. Among them, soil temperature was significantly correlated with sap flow. Further exploration of the response of tree traits to the environment is needed in the future. [ABSTRACT FROM AUTHOR]

Density peak clustering(DPC) combines the local density and relative distance of data sample points, and can cluster arbitrary shaped datasets. However, DPC algorithm has problems such as subjective selection of truncation distance, simple allocation strategy, and high time complexity. This paper proposed a density peak clustering algorithm based on grid nearest neighbor optimization(KG-DPC algorithm). Firstly, it gridded the data space to reduce the computational burden of distance between sample data points. When calculating local density, not only the density values of the grid itself were consi-dered, but also the density values of the surrounding k nearest neighbors were considered, reducing the impact of subjective selection of truncation distance on clustering results, improving clustering accuracy, and setting a grid density threshold to ensure the stability of clustering results. The experimental results show that the KG-DPC algorithm has a significant improvement in clustering accuracy compared to DBSCAN, DPC, and SDPC algorithms. Compared to DPC, SNN-DPC, and DPC-NN algorithms, the average consumption time in clustering is reduced by 38%, 44% and 44%, respectively. On the basis of ensuring the accuracy of basic clustering, the KG-DPC algorithm has specific advantages in clustering efficiency. [ABSTRACT FROM AUTHOR]

In response to the presence of corrosive gases such as H2S and HC1 in biomass gas, which can easily corrode internal combustion generators and pipeline systems, a study was conducted on the purification of biomass gas using hydroxyl iron oxide high sulfur capacity desulfurization technology and a composite layer long life dechlorination system; at the same time, an intelligent response strategy for rapid active power balance is proposed to address the frequency lini让 issue caused by significant power imbalance during the switching process of biomass microgrids and off the grid・ After research, the sulfur capacity of hydroxyl iron oxide prepared with NH4HCO3 can reach over 50%, and the outlet concentration of hydrogen sulfide is less than 1 mg/L・ After dechlorination in a composite bed, the service life can reach over 30 d when the outlet HC1 is less than 0・ 5 mg/L ・ Simultaneously, through intelligent distributed power generation power regulation and precise load control, the rapid balance of active power within the microgrid during islanding can be achieved・ It can control the frequency fluctuation w让hin the microgrid within 5%. [ABSTRACT FROM AUTHOR]

Aiming at the problem of stamping machine fault monitoring based on the Internet of Things (IoT), in order to reduce the computational complexity of stamping machine fault monitoring and improve the accuracy of low-frequency identification, a real-time mechanical fault acoustic monitoring method without machine learning technology was proposed, which was based on the cumulative real-time series-parallel transformation algorithm for mechanical fault acoustic monitoring. Firstly, the necessity of acoustic low-frequency analysis of stamping machine tool in the scene of Internet of Things was studied, and the expression of acoustic signal was given. Then, aiming at the difficulty of parameter estimation caused by the overlapping of multiple periodic signals on the frequency axis, an accumulative real-time serial-parallel transformation algorithm was proposed. The input sampling sequence was fed into a plurality of serial-parallel converters with different output ports, and the maximum absolute value was detected and compared from the accumulated waveforms. Finally,by dividing the sample time slots, the cumulative real-time serial-parallel transformation algorithm was applied to mechanical fault monitoring. The feasibility of the proposed algorithm in mechanical acoustic monitoring and real-time mechanical fault acoustic monitoring method were verified by simulation and real machine test of stamping machine. The research results show that the cumulative real-time serial-parallel transformation algorithm is beneficial to improve the identification accuracy of low-frequency band without a large number of signal samples. In the aspect of histogram correlation, the cumulative real-time series-parallel transform algorithm and Morlet wavelet transform have the same performance, and both are obviously better than short-time Fourier transform. At the same time, although the cumulative real-time serial-parallel transform algorithm needs 2.5 times more additions than Morlet wavelet transform, the total number of multiplications is reduced by 20 447 %, which greatly reduces the computational complexity. [ABSTRACT FROM AUTHOR]

目的: 探究鹅去氧胆酸抗脂多糖诱导的BV2小胶质细胞炎症反应作用及机制, 旨在为相关人员的研究 工作提供参考资料。方法: 实验于25~100 µmol/L CDCA预处理BV2细胞2小时, 在此之后利用200 µg/L LPS处理, 时 间为 22h, 经 Griess 法测定 NO, 经 Western blot 检测COX-2和iNOS蛋白, 经 RT-PCR 分析 TNF-α、IL-6、IL-1β 和 TGR5 mRNA。应用 Western blot, 开展 1hLPS 处理后的NF-κB、IκBα和Akt磷酸化水平检测, 免疫荧光用于观察 NF-κB 核内转 移。结果: 相较于对照组, 模型组的 NO 含量显著升高, COX-2 和 iNOS 蛋白表达增强, TNF-α、IL-6 和 IL-1β mRNA 上 调, TGR5 mRNA 表达表现出了降低趋势, 其主要伴随 NF-κB 信号通路的激活。CDCA 处理有效逆转上述变化, 应用该 法能够在极大程度上降低炎性因子表达量以及 NO 含量, 抑制 NF-κB 信号通路激活, 上调 TGR5 mRNA。结论: CDCA 能对 LPS 诱导的 BV2 细胞的炎症反应进行有效抑制, 其作用机制可能与激活 TGR5、抑制 Akt/NF-κB 通路激活有关。 [ABSTRACT FROM AUTHOR]

The formation age, characteristics of zircons and the source of breccia in the lower section of Xidong Group volcano breccias in the upper Cretaceous Formation from Shuiwen Basin(Guangxi) and its geological significance are studied via the zircon U-Pb geochronology and petrography. The volcanic breccias are mainly composed of abundant sandstone breccias and metamorphic sandstone breccias, magma fragments, glasses, and fine felsic minerals. The U-Pb dating results of zircons are mainly from 418 to 469 Ma, with the younger ages at 107, 104 and 90 Ma. The Th/U ratios of zircons are greater than 0. 1, and chondrite normalised REE patterns of zircons for volcanic breccias has obvious positive Ce and negative Eu anomalies, indicating that they are magmatic zircons. The study of zircon morphology shows that the older zircons have a high psephicity, with their zonings not clear, the younger zircons a low psephicity, but their zonings relatively developed. Regional geological data show that the U-Pb ages of clastic zircons obtained from the metamorphic sandstones originally divided into the Neoproterozoic are from 393 to 456 Ma. Therefore, this paper believes that the zircons at 418-469 Ma in the lower part of Xidong Group in Upper Cretaceous Formation are not the diagenetic ages of the volcanic breccias. The zircons in this age range may come from the sandstone breccia of the Lower Cretaceous or from the metamorphic sandstone breccia that was once thought to be of the Neoproterozoic. The zircon age of 90 Ma probably represents the age of deep magmatic eruption activity before the formation of volcanic breccia in the lower part of Xidong Group in the Upper Cretaceous. It is 7 Ma earlier than that of the quartz porphyry in the upper part. [ABSTRACT FROM AUTHOR]

To establish a method for the high-sensitivity, accurate, and rapid determination of volatile phenols in water by continuous flow injection analysis. Volatile phenols were released from the sample through distillation under acidic conditions. In a weakly alkaline medium with a pH of (10.0±0.2), volatile phenols could react with 4-aminoantipyrine to form salmon pink compounds after oxidation by potassium ferricyanide, and the absorbance was measured at 505 nm. Based on this principle, the analysis was carried out using the continuous flow analyzer AA3 in bubble isolation mode, with online distillation and online colorimetry. The concentration of volatile phenols showed linearity in the range of 0 to 0.100 mg/L, with a detection limit of 0.97 μg/L. The method is suitable for the determination of trace volatile phenols in large volumes of water samples. [ABSTRACT FROM AUTHOR]

Objective　To observe whether Huashi Runjing Decoction can inhibit the inflammatory response in rats with desmoplastic male dry eye disease, and to explore its potential mechanism of action. Methods　60 healthy male SD rats were randomly divided into 4 groups：sham surgery group of 15, negative control group of 15, positive control group of 15, Huashi Running Decoction group of 15) . The sham operated group rats only underwent abdominal incision without removing both testicles and epididymis；Rats in the negative control group, positive control group and Huashi Runjing Decoction group were removed both testicles and epididymis. After 1 week of modeling, the model was validated by fluorescein staining (FL), break-up time (BUT), and tear secretion test (SIT) . After the wound healed, the rats were given the appropriate drug interventions. The degree of corneal breakage, tear film rupture time and tear secretion of rats in each group were detected by FL method, BUT method and SIT method respectively after 8 weeks of drug administration. The levels of COX-2, TNF-α and IL-6 in the serum of each group of rats were observed by ELISA; HE staining was used to observe the pathomorphological changes in the lacrimal gland tissue of rats in each group. The expression of key inflammatory factors COX-2, TNF-α and IL-6 in the lacrimal gland tissues of rats in each group was observed by immunohistochemistry and Western blot. Results　Compared with the sham-operated group, the negative control group, positive control group and Huashi Runjing Decoction group showed an increase in the area of sodium fluorescein positive staining in the cornea, a significant increase in FL score, a shortening of tear film rupture time and a decrease in tear secretion, an increase in serum COX-2, TNF-α and IL-6 levels, atrophy of the lacrimal gland tissue vesicles, an irregular shape, a disorganized structure, a decrease in intracytoplasmic zymogen particles, and a large number of inflammatory cell infiltrations. The expression levels of inflammatory factors COX-2, TNF-α and IL-6 increased in the tissues ( P < 0.05) ; Compared with the negative control group, the Huashi Runjing Decoction group showed a significant decrease in the area of sodium fluorescein positive staining, a significant decrease in FL score, a significant increase in tear film rupture time and tear secretion, a decrease in serum COX-2, TNF-α and IL-6 levels, a decrease in atrophy of the lacrimal gland tissue vesicles, a more regular shape, a clearer structure, an increase in the number of intracytoplasmic zymogen particles, an increase in inflammatory cell infiltration and a decrease in the area of lacrimal gland tissue. The expression levels of COX-2, TNF-α and IL-6 in lacrimal gland tissues were reduced (P < 0.05) . Conclusion　Huashi Runjing Decoction could reduce the protein expression of COX-2, TNF-α and IL-6 in the lacrimal gland tissue of castrated male dry eye disease rats, and inhibit the inflammatory response. [ABSTRACT FROM AUTHOR]

Objective To investigate the application value of cardiac magnetic resonance (CMR) endogenous contrast T1ρ technique in early screening of myocardial fibrosis in patients with type 2 diabetes mellitus (T2DM). Methods　Twenty patients with T2DM (T2DM group) and 20 healthy controls matched in age, sex, body surface area and body mass index were prospectively enrolled. All subjects underwent CMR cine, T1 mapping, T1ρ (5 Hz and 400 Hz), and late gadolinium enhancement (LGE) sequence. The subject′s left ventricular cardiac function, native T1 values, T1ρ values, extracellular volume (ECV) and myocardial fibrosis index (mFI) were acquired. The differences between the two groups were compared by Student t-test, and the correlation between ECV, mFI, T1ρ, native T1, glycated hemoglobin A1c (HbA1c) and duration of diabetes in the T2DM group was analyzed. Results　The ECV [(31.90±2.28)%], T1ρ values [(50.35±1.91) ms], native T1 values [(1 075.25±9.22) ms] and mFI values [(7.22±2.33) ms] were higher in the T2DM group than controls [ECV (26.05±1.70)%, T1ρ (46.86±2.01) ms, native T1 values (1 052.15±25.25) ms, mFI values (5.45± 2.78) ms] were significantly elevated (P<0.05). There was a positive correlation between ECV and mFI (r=0.62, P=0.003), T1ρ (r=0.59, P=0.005), native T1 (r=0.50, P=0.023), HbA1c (r=0.57, P=0.008) and duration of diabetes (r=0.48, P=0.030). Conclusion　Magnetic resonance endogenous contrast T1ρ technology can early screening myocardial fibrosis in patients with T2DM, which has potential clinical application value in evaluating myocardial fibrosis. [ABSTRACT FROM AUTHOR]

In long-term outdoor operation, both crystalline silicon solar cells and thin film solar cells are subject to potential-induced degradation (PID), decreasing the output power of photovoltaic modules. Despite numerous studies in the past, the understanding of the PID phenomenon and its solutions is still incomplete. In order to promote a deeper understanding of the PID phenomenon in solar cells and provide guidance for stability research of solar cells, the causes of PID in crystalline silicon solar cells and thin film solar cells, as well as related solutions are reviewed in this paper. [ABSTRACT FROM AUTHOR]

Objective To observe the serotonin transporter （SERT） expression in colorectal cancer SW480 cells after treatment with erastin and investigate the effect of regulated SERT expression combined with erastin on ferroptosis in colorectal cancer cells. Methods The colorectal cancer SW480 cells were treated with erastin. CCK8 assay was used to verify cell viability, Western blot was used to evaluate the expression of SERT and ferroptosis related proteins such as SLC7A11, GPX4 and ACSL4, and flow cytometry was used to analyze the levels of ROS in the cancer cells. siRNA interference was used to down-regulate SERT expression in the SW480 cells and the effect of ferroptotic death in the cancer cells treated with regulated SERT combined with Erastin were observed. Results SW480 cells treated with 10 μmol erastin induced ferroptosis and significantly upregulated SERT expression in the cancer cells. The ferroptotic resistance proteins SLC7A11 and GPX4 in the cancer cells induced by erastin combined with siSERT were significantly reduced, while the ferroptotic executive protein ACSL4 was significantly increased. 5-HT stimulation not only reversed the reduction of SLC7A11 and GPX4 and ferroptosis caused by erastin on SW480 cells, but also inhibited the synergistic ferroptotic effect of erastin combined with siSERT. Conclusion Erastin induces ferroptotic cell death in SW480 cells and upregulates SERT expression in a compensatory way. Inhibited SERT can increase ferroptotic sensitivity of colorectal cancer cells to erastin. [ABSTRACT FROM AUTHOR]

A series of true triaxial compression tests on sandstone were carried out based on the true triaxial testing machine. The sandstone samples were taken from a gas storage facility， with a buried depth of 3600 meters. The strength and deformation characteristics of deep sandstone under true triaxial stress were studied， and the elastic modulus， cohesion， friction angle and peak failure strength of deep sandstone and shallow sandstone were compared. The results show that with the increase of the intermediate principal stress， the peak strength of the deep sandstone will also increase， the crack initiation stress and the damage stress of the deep sandstone will also increase， and the intermediate principal strain at the peak will decrease. With the increase of sandstone depth， the elastic modulus， cohesion and friction angle of sandstone all show an increasing trend. The octahedral shear stress of the peak failure strength of the shallow rock and the effective mean normal stress show a nonlinear relationship， while the octahedral shear stress of the peak failure strength of the deep rock has a linear relationship with the effective mean normal stress. And the Mogi-Coulomb criterion is more suitable for reflecting the strength characteristics of deep sandstone at failure. [ABSTRACT FROM AUTHOR]

Aromaticity is one of the most important concepts in chemistry. However, there is still no unified chemical insight for various systems with conjugated sp2 carbon. Herein, we proposed a superatomic-molecule theory to build a generalized electron rule for polycyclic conjugated hydrocarbons, fullerenes and 2D periodic materials. Taking benzenoid units as 2D superatoms, polycyclic conjugated hydrocarbons and C60 can be seen as superatomic molecules consisting of bonded superatoms, resulting in local aromaticity. In superatomic molecules, π electrons are not totally delocalized, but localized in a single superatom forming superatomic lone pairs or shared by two atoms forming a superatomic bond, mimicking rules in classical valence bond theory. Moreover, two 2D superatomic crystals (C18H6 and C54H18) are predicted to have fairly large band gaps (∼1.8 eV), although the π electrons are conjugated and delocalized. The proposed superatomic-molecule theory provides generalized chemical insights into the nature of local aromaticity, which can be qualitatively evaluated by the chemical intuition given by superatomic Lewis structures. [ABSTRACT FROM AUTHOR]

Objective To investigate the relationships between microRNA（miRNA）-216a-5p，thyroid hormone re⁃ ceptor interacting protein 4（TRIP4）expression and the pathological parameters and prognosis of patients with breast can⁃ cer. Methods Eighty-five cases of breast cancer patients were collected，and the expression of miR-216a-5p and TRIP4 in the cancerous tissues and adjacent tissues were detected by qRT-PCR. We analyzed the relationships between the two and the clinicopathological characteristics of patients. After 3 years of follow-up，they were divided into the high miR216a-5p expression group（≥0. 430，44 cases）and low miR-216a-5p expression group（<0. 430，41 cases），high TRIP ex⁃ pression group（≥1. 886，42 cases）and low TRIP expression group（<1. 886，43 cases）. The prognosis of patients with dif⁃ ferent expression was compared. Results The miR-216a-5p expression was lower in the breast cancer tissues（0. 430 ± 0. 109）than that in the paraneoplastic tissues（1. 012±0. 166），and TRIP4 expression was higher（1. 886 ± 0. 388）than that in the paracarcinoma tissues（1. 023 ± 0. 171），with statistically significant difference（both P<0. 05）. The miR216a-5p was negatively correlated with TRIP4 expression in breast cancer tissues（r=-0. 637，P<0. 05），and both were as⁃ sociated with human epidermal growth factor receptor-2（HER-2）expression，Ki-67 proliferation index，TNM stage，and lymph node metastasis（all P<0. 05）. The 3-year progression-free survival rate and overall survival rate in the high miR216a-5p expression group were higher than those in the low miR-216a-5p expression group，while the 3-year progressionfree survival rate and overall survival rate in the high TRIP expression group were lower than those in the low TRIP expres⁃ sion group（all P<0. 05）. Conclusion Low expression of miR-216a-5p and high expression of TRIP4 in breast cancer tissues are associated with HER-2 expression，Ki-67 proliferation index，TNM stage，lymph node metastasis and prognosis. [ABSTRACT FROM AUTHOR]

Heat pipe is a kind of multi-scale heat transfer material with high thermal conductivity. It is widely used in the fields of heat recovery and reuse of heat exchanger, solar collector and data center cooling. The experimental study on the influence factors of micro heat pipe heat transfer was carried out from the aspects of cyclic power and performance. According to the structure composition and working mechanism of the flat micro-heat pipe, the research progress of flat micro heat pipe groove structure, filling working fluid, filling rate and working condition of the tube was reviewed. The relationship between the state of evaporating section and condensing section and the flow state and heat transfer characteristics was analyzed, such as curvature radius, flow rate and effective thermal conductivity. The development of model structure design and theoretical prediction of flat micro-heat pipe was summarized, and the development trend of micro-channel of micro-heat tube was prospected. [ABSTRACT FROM AUTHOR]

The experiment was to explore the effect of different selenium sources on growth performance, serum biochemical indexes and meat quality of finishing pigs. A total of 240 'Duroc×Landrace×Yorkshire' boars were selected and randomly divided into four groups, with six replicates in each group and ten pigs in each replicate. The boars in group A were fed with basic diet, boars in group B, group C and group D were fed with 30 g/t sodium selenite, 150 g/t yeast selenium and 60 g/t nano selenium in basic diet, respectively. The level of selenium was 0.3 mg/kg. The test period is 60 d. The results showed that the ADG of pigs in group B, group C and group D were 6.97%, 12.08% and 12.96% higher than those in control group (P<0.05). The feed to gain ratio of pigs in each test group was significantly lower than that in control group (P<0.05). The eye muscle area of each experimental group was significantly higher than that of control group (P<0.05). The T-AOC and the activity of GSH-Px in serum of pigs in group C and group D were significantly higher than those in group B and control group (P<0.05), the activity of CAT in serum of pigs in each test group was significantly higher than that in control group (P<0.05), and the activity of SOD in serum of pigs in each test group was significantly higher than that in control group (P<0.05). The content of MDA in pig serum of each test group was significantly lower than that of control group (P<0.05). The content of serum IgG and the activity of LZM in group C and group D were significantly higher than those in group B and control group (P<0.05). The content of IgA in pig serum of each test group was significantly higher than that of control group (P<0.05). The content of selenium in serum of pigs in each test group was significantly higher than that in control group (P<0.05). The water loss rate of pigs in group C and group D was significantly lower than that in sodium selenite group and control group (P<0.05), and the pH24 h value of pork was significantly higher than that in group B and control group (P<0.05). The content of linoleic acid and myristic acid in longissimus dorsi muscle of pigs in test group was significantly higher than that in control group (P<0.05). The breeding profits of fattening pigs in group B, group C and group D were 69.88, 120.28 and 130.20 yuan higher than those in control group, respectively. The experiment indicates that when the level of selenium is 0.3 mg/kg, the effect of adding nano selenium to the diets of finishing pigs is better. [ABSTRACT FROM AUTHOR]

China has extensive livestock and poultry industries with substantial production and use of veterinary antibacterials. The longterm and massive use of veterinary antibacterials causes environmental pollution, increases bacterial resistance, and elevates safety risks for livestock, poultry, and agricultural products, further threatening human health. In this paper, we review the use of veterinary antibacterials in livestock and poultry breeding from 2009 to 2019 in China. The characteristics of the usage of veterinary antibacterials were analyzed. The findings show that the proportion of consumption of veterinary antibacterials in veterinary chemicals was 69.6%~74.1%. The utilization of veterinary antibacterials reached a maximum in 2014, and then decreased yearly. The main types of veterinary antibacterials are tetracycline, chlortetracycline, and oxytetracycline; chlortetracycline and oxytetracycline are mainly used to promote growth. Furthermore, the analysis of the antibiotics residue in different foods showed that the detection rates of antibiotics in milk, cultured fish, and vegetables were as high as 90.9%~100%. The average residue of quinolone in cultured fish was 725.13 μg·kg-1, which exceeds the national food safety limit standard (100 μg·kg-1). Additionally, we summarize the situation of antibiotic residues in the environment and the emergence and mechanism of bacterial resistance. The effects of the massive use of antibiotics on animal and human health are discussed. Ultimately, management suggestions and strategies on the prevention of antibiotics pollution are proposed in terms of source, use, emission, and remediation to help control antibiotic pollution. [ABSTRACT FROM AUTHOR]

In order to improve the accuracy of well trajectory calculation in measurement while drilling, a segmented well trajectory calculation method based on magnetic inertia measurement is proposed in this study. When the drill bit is stopped, the tool face angle model recognition method is used to identify the borehole trajectory model of the test section, and the sub-measurement points of the test section under the constraints of the model are generated according to the depth change in the real-time measurement data. Then, the magnetic inertia measurement data is used to correct the measured points, and the corrected points are identified by piecewise trajectory model. Finally, the corresponding models are calculated by piecewise model. The experimental results show that the absolute error of the coordinate increment is reduced from 0.840 m of the single model algorithm to 0.146 m after adopting the new method, which shows that compared with the single model of the well trajectory calculation method, the error of the segmented well trajectory calculation method is smaller and the wellbore trajectory calculation method can improve the accuracy of the borehole trajectory calculation. [ABSTRACT FROM AUTHOR]

Objective To study the distribution and drug resistance of clinical bacterial isolated from common infections in a hospital from 2018 to 2020, so as to provide a referential basis for clinicians to enhance rational use of antibiotics. Methods The distribution and drug resistance data of bacterial isolated from the hospital clinical specimens from 2018 to 2020 were retrospectively analyzed, and the Antimicrobial Susceptibility Test results were interpreted based on the file issued by the American Society for clinical and laboratory standardization in 2019. Results From 2018 to 2020, a total of 6 862 bacteria were detected, of which 840 were gram-positive bacteria (12. 24%), 5 863 were gram-negative bacteria (85. 44%). The results showed negative for Vancomycin and linezolid resistant Staphylococcus. However, only a few results were positive for Vancomycin resistant Enterococcus. The top four detection rates of gram-negative bacteria were klebsiella pneumoniae [19. 67% (1 350/6 862], Singular deformed rod [8. 96% (615/6 862)], Escherichia coli [7. 74% (531/6 862], Serratia marcescens[2. 93% (201/6 862]. Enterobacteriaceae had low resistance rates to β-lactams, aminoglycosides and carbapenems, and A. baumannii had a high resistance rate to imipenem (77. 01%). Conclusion The analysis of bacterial resistance is of great significance to the rational application and scientific management of antimicrobial agents in hospitals, therefore, surveillance of bacterial resistance should be strengthened. [ABSTRACT FROM AUTHOR]

In view of the problem that the wellbore trajectory fitting deviates from the true drilling trajectory caused by the changeable wellbore trajectory shape and the single inclination mode, this study proposes a method of wellbore trajectory segmentation and pattern recognition based on characteristic parameters. On the basis of sufficient theory, the cubic b-spline function of well inclination and azimuth with well depth is established, and the curve characteristic parameters which can determine the adjacent shape of a certain point of the well trajectory are obtained. According to the characteristic parameters, and combined with the characteristic parameters of various models, the wellbore pattern recognition evaluation index and segmentation index are constructed, and the wellbore trajectory model that best matches the actual drilling is selected. In order to verify the effectiveness of this method, a prototype is designed to simulate the actual drilling experiment. The results show that the wellbore trajectory pattern recognition and segmenting method based on characteristic parameters can significantly improve the accuracy of wellbore trajectory fitting. [ABSTRACT FROM AUTHOR]

The crystals are beautiful and useful, and the structure is harmonious and orderly. Photoelectric functional crystal can realize the interconversion of optical and electric energy, and occupy an important position in the high-tech fields of microelectronics, optoelectronics, communications, aerospace and modern military technology. People' s understanding of crystals is derived from natural minerals. From the discovery of mineral crystals to the artificial growth and application of photoelectric functional crystals, great progress has been made in crystal types, crystal quality, growth theory, growth technology and application. The development process from mineral gem to crystallography is briefly described, the development process of several kinds of photoelectric functional crystals such as piezoelectric crystal, electro-optic crystal, laser crystal, nonlinear optical crystal and scintillation crystal is introduced, and research progress on crystal growth is summarized in this paper. [ABSTRACT FROM AUTHOR]

The study was to explore the optimum fermentation process of Sijunzi decoction and the changes of different components before and after fermentation. With the content of total flavonoids as index, the fermentation process of Sijunzi decoction by lactic acid bacteria was optimized by single factor and response surface methodology. The content of total flavonoids, total polysaccharides and nucleosides in Sijunzi decoction before and after fermentation were investigated by UV spectrophotometry and HPLC. The results showed that the optimal liquid fermentation conditions of Sijunzi decoction were inoculum 3%, fermentation temperature 32 ℃, fermentation time 24 h, shaking speed 120 r/min. The increase of total flavonoids content and total polysaccharide content in Sijunzi decoction after fermentation was 38.45% and 11.06%, respectively. The chromatographic results showed that the content of nucleosides and flavonoids in Sijunzi decoction after fermentation increased compared with those before fermentation. The study indicates that lactic acid bacteria liquid fermentation can increase the content of total flavonoids, total polysaccharides and nucleosides in Sijunzi decoction, indicating that strain fermentation is helpful to improve the content of effective components in traditional Chinese medicine compound. [ABSTRACT FROM AUTHOR]

Rejection has constantly been an unresolved challenge in the field of organ transplantation. The research on the mechanism of rejection plays a significant role in improving the efficacy of organ transplantation and enhancing the survival rate of graft. The innate and specific immune responses of the human body jointly participate in the graft rejection, leading to graft injury. In recent years, multiple researchers have conducted in-depth studies on the mechanism underlying the role of microRNA (miR) in regulating rejection. Among them, miR-155 has been widely considered as a key factor involved in immune regulation. The expression level and functional status of miR-155 may be intimately associated with the occurrence of rejection, which may become a new target for overcoming rejection. In this article, relevant studies on the role of miR-155 in regulating key immune cells in innate and specific immune responses were reviewed, aiming to provide novel ideas for the development of new immunosuppressants and rejection therapy. [ABSTRACT FROM AUTHOR]

To solve the car-following problem of intelligent and connected vehicle (ICV), a car-following model of ICV was proposed, and the model properties were analyzed. Considering the car-following property of variable headway, the ICV car-following model was proposed to maintain simple model structure and clear physical meaning of model parameters. Based on the function of spacing and speed at equilibrium state, the flow-density function curve of the proposed ICV car-following model was calculated. The mechanism of improving traffic capacity by the proposed ICV car-following model was also analyzed. From the perspective of microcosmic kinematics, the stability criterion of the proposed ICV car-following model was theoretically derived. The results show that according to the proposed ICV carfollowing model, the maximum capacity can be obtained with the density of 66. 887 2 car · km -1 and the speed of 63. 576 0 km ·h -1. The model stability criterion is related with traffic flow speed and can be stable at any speed, which shows that the model has good model stability condition. [ABSTRACT FROM AUTHOR]

In view of the problem of serious distortion of gravitational acceleration information caused by bottom-hole vibration and noise during measurement while drilling, a method that combines generalized regression neural network and improved recursive least squares is proposed to remove noise. Using the principle of mutual cancellation of adaptive noise, the accelerometer measurement signal and drilling tool vibration signal are used as the main noise model, and the drilling tool vibration signal processed by the generalized regression neural network is used as the auxiliary noise model. Recursive least squares filter processing is used to improve the accuracy of drilling tool accelerometer measurement and calculate real-time drilling attitude information. The simulation results show that the proposed algorithm can effectively remove the vibration and noise of the drilling tool accelerometer and improve the attitude measurement accuracy. After denoising, the calculated deviation angle error is within 1.45°, and the tool face angle error is within 1.65°. [ABSTRACT FROM AUTHOR]

The development of inexpensive, efficient and stable catalysts for advanced oxidation technologies is essential for water treatment. In this study, a novel "in-situ precipitation calcination" method was developed using hydrotalcite/chitosan as the precursor to prepare a magnetic nitrogen- doped carbon supported CoFe2O4 -CoO catalyst ( LDO/ NC) . The catalyst was used to activate peroxymonosulfate (PMS) for tetracycline de gradation, and it showed significantly better catalytic activity than naked hydrotalcite oxide ( LDO ) and nitrogendoped carbon (NC) . As a carbon and nitrogen source, the in-situ incorporation of chitosan effectively suppressed the agglomeration of cobalt-iron metaloxide. Meanwhile, the N atom enhanced electron transfer, thus improving the catalytic activity. The effects of catalyst com position, catalyst dosage, PMS dosage and initial pH value on the degradation efficiency of TC were also investigated. Under the optimal conditions (PMS dosage 0. 4 g L - l, LDO/NC dosage 0. 5 g L - l, pH= 5), the degradation efficiency and total carbon removal rate of TC within 30 min reached 97. 8 % and 81. 0 %, respectively. The catalyst can be magnetically recovered and reused for more than five times with good stability. This study provides a promising green catalyst for the PMS-assisted degradation of pharmaceutical wastewater. [ABSTRACT FROM AUTHOR]

In view of the data drift problem of MEMS gyroscope caused by vibration while drilling, a spiking neural network algorithm is proposed in this study. First, according to the time characteristics of the drift error of the gyroscope, the pulse time of the spiking neural network is used to encode the information intensity of the gyroscope. Then, the synaptic plasticity of the Izhikevich neuron model is used to adjust the excitatory synaptic conductance and inhibitory synaptic conductance to enhance the robustness of the network, thereby improving the anti-interference ability of the gyroscope signal against noise. Finally, under different vibration frequencies, the correlation between the firing rate of the Gaussian white noise output neuron and the membrane potential is analyzed. Experimental results show that under strong vibrations of different frequencies, noise has little effect on the firing rate of output neurons and the relative change of firing rate of output layer neurons, and has little effect on the membrane potential of output layer neurons, but has a greater impact on the correlation between membrane potentials. These results indicate that the proposed method improves the anti-interference ability of the gyroscope under vibration and noise, and can provide a new idea for the processing of gyroscope drift. [ABSTRACT FROM AUTHOR]

Since 2009, Nanjing University has implemented the “Three-stage & Three-Track” undergraduate teaching reform. In line with this concept, the experimental teaching of chemistry has undergone continuous reform to cultivate studentsʼ solid professional practice skills, strong interdisciplinary abilities, and enhanced comprehensive and innovative practical capabilities. Instruments and equipment have played an important supporting role in this reform. To effectively utilize the limited large instruments to meet the needs of various experimental courses, the National Demonstration Center for Experimental Chemistry Education (Nanjing University) has established a high-quality, teaching-oriented public instrument platform, focusing on cultivating “four practical abilities”. However, optimizing the utilization of resources through open sharing of instruments, while balancing teaching tasks, remains an important challenge requiring ongoing exploration. This paper presents the management mechanisms adopted by the platform in experimental teaching, instrument training, sharing and opening, using the public instrument platform of the National Demonstration Center for Experimental Chemistry Education (Nanjing University) as a case study. It highlights the achievements made, providing a reference for similar instrument platforms at other domestic universities. [ABSTRACT FROM AUTHOR]

Tandem repeat sequences are difficult part in genome construction, due to the high similarity between repeated units and the ambiguity in copy numbers, it often result in multiple candidate positions during sequence alignment. The challenge lies in rapidly and accurately filtering out the correct alignment positions. Existing methods address this issue by using seeds (short sequences selected from sequencing fragments) to locate and extend candidate alignment positions, but overlook the distinctive characteristics of tandem repeat sequences when selecting seeds. To tackle the problem, this paper proposed a position filtering method for tandem repeat sequence alignment, which filtered alignment results by calculating the similarity of rare kmer sequences. Additionally, it implemented a strategy of merging rare kmers to expedite computation, coupled with a fuzzy search based on edit distance to enhance filtering information density. Experimental results demonstrate that this approach improves both the recall and accuracy of alignment results on simulated datasets while achieving approximately a 2-fold increase in computational speed compared to existing methods, with notable parallel acceleration effects. [ABSTRACT FROM AUTHOR]

To investigate the feasibility of solid-state fermentation of low-grade tobacco leaves with Eurotium cristatum, E.cristatum was isolated from Fuzhuan tea and inoculated into low-grade tobacco leaves for solid-state fermentation.Simultaneous distillation extraction and GC/MS were used to detect the changes in the main aroma components of tobacco leaves at 1, 3, 5, 7 days during solid-state fermentation.Sensory evaluation was conducted to investigate the impact of solid-state fermentation time on tobacco quality.The candidate strain GT-1 was successfully isolated from Fuzhuan tea, and confirmed as E.cristatum by morphological and molecular identification.The results showed that the sensory quality of tobacco leaves was the best after fermentation for 5 days, and the aroma amount, concentration and aftertaste were significantly improved compared with untreated tobacco leaves.A total of 33 main aroma components were detected, including 16 carotenoid degradation products, 9 aromatic amino acid conversion products, 1 chlorophyll degradation product, 1 of cembranoid degradation products, and 6 Maillard reaction products.With the extension of solid-state fermentation time, the total amount of main aroma components in tobacco leaves shows a trend of increasing and then decreasing.The total amount of aroma components reaches its highest point at 402.03 μg/g on the 5th day.Compared to the CK, the content of aroma components increased by 22.54%.Among them, the content of aroma substances such as 4, 7, 9-macrostigmen-3-one, geranylacetone, dihydrokiwifruit lactone, benzyl alcohol, phenylethanol, and 2-acetylpyrrole were significantly increased, which greatly enriching the sweet, tobacco, fruit, flower aromas of the smoke.Solid-state fermentation with E.cristatum GT-1 can increase the content and variety of aromatic substances in tobacco leaves, and thus effectively improve the quality of low-grade tobacco leaves. [ABSTRACT FROM AUTHOR]

In order to explore the hotspots and research trends of domestic research on biochar in tobacco agriculture in recent years, bibliometric methods were used to analyze papers about biochar application in tobacco planting research included in the China National Knowledge Infrastructure (CNKI). The numbers, annual distribution, author information, publications and research content were statistically analyzed, and the CiteSpace V visualization software was used to predict and analyze research hotspots. The results showed that a total of 114 journal papers and 81 dissertations on the application of biochar to tobacco planting were retrieved, including 8 doctoral dissertations and 73 master’ s dissertations. The institution with the most research in China was Henan Agricultural University, and Liu Guoshun was the scholar with the most published papers. Domestic research on tobacco biochar still lacked a stable core author group, and the number of core authors was small. Tobacco biochar application hotspots focused on tobacco quality, chemical composition and tobacco-growing soil. In recent years, research hotspots tended to be on the effects of biochar on soil microbial communities and heavy metals in tobacco leaves. [ABSTRACT FROM AUTHOR]

Improper addition or excessive use of excessive heavy metal elements in feed will cause great harm to physiological health of animals. Excessive heavy metal elements have negative impact on animal's body tissues, immune system, reproductive capacity and production performance. Toxicity of excessive heavy metal elements is mainly manifested in changing signal pathways in animals, inducing oxidative stress in body and causing damage to animal nerves. The paper aims to analyze the effect of excessive heavy metals on animal health and explore toxic effect and mechanisms of excessive heavy metals, to provide basis for use of excessive heavy metal elements in actual production in future. [ABSTRACT FROM AUTHOR]

Objective　 To analyze the clinical features of adult hemophagocytic syndrome （HPS） and the correlation between the levels of various cytokines and prognosis. Methods　 The data of 19 adult patients with hemophagocytic syndrome were collected, and the clinical features and laboratory tests were analyzed. The blood samples were collected for 12 cytokine levels detection, and the correlation between the levels and prognosis was analyzed. Results　The levels of cytokines IL-1β, IL-2, IL-4, IL-8, IL-10, IL-6, IFN-γand TNF-α in HPS patients were higher than those in non-HPS non-infected patients （P < 0.05）. The levels of IL-4, IL-5, IL10, IFN-γ and TNF-α in HPS patients were higher than those in non-HPS patients （P < 0.05）, the ROC curve of IL-10, IFN-γ and TNF-α showed that the AUC of IL-10, IFN-γ and TNF-α was between 0.7 and 0.9, indicating accuracy in the diagnosis of HPS. Fib was significantly lower than that in the survival group （P < 0.05）, while there were no significant differences in age, sex, clinical features （fever, liver, spleen, lymphadenopathy） and laboratory tests （ALT, AST, TBIL, ALB, Fer, TG, ACN, HGB, PLT） between the HPS death group and the survival group （P > 0.05）, and the levels of IL-1β, IL-8 and TNF-α in HPS death group were significantly higher than those in survival group （P < 0.05）. Conclusion　HPS may present increased levels of various cytokines, among which IL-10, IFN-γ and TNF-α may be significant for the diagnosis of HPS. The significant decrease of Fib and the significant increase of IL-1β, IL-8 and TNF-α may indicate a poor prognosis. [ABSTRACT FROM AUTHOR]

This paper proposed a self-encoding salient region extraction algorithm based on multi-layer convolutional to solve the problem that the existing convolutional neural network wasn’t sufficient in extracting image features, which led to the poor effect of salient extraction. When convolutional networks were used to extract image features, the shallow convolution features generally extracted the detailed features of the image, such as color, texture and location features, and the deep convolution features were generally referred to the semantic features of the image. On the coding layer, this algorithm downsampled the shallow convolution features and fused them into the deep convolution features, and upsampled the deep convolution features to the shallow convolution feature. Experiments show that this method can greatly improve the coding quality. In the decoding, it also fused the convolutional features by encoding to obtain the lost information in the decoding and also obtained a better decoded image. In addition, this paper designed a layer-by-layer supervision method to guide the training of the decoding layer, which used the standard region extraction map by down-sampling as the standard image for supervision training. The experimental results show that this algorithm can increase the F-measure by 0.071 on the basis of PAGRN, and reduce the MEA by 0.031 on average. [ABSTRACT FROM AUTHOR]

The Mars flux has great influence on the solar panel temperature. This paper establishes a mathematical model of the Mars albedo flux and analyzes the variation of the solar panel temperature in the near Mars area and the far Mars area when the Mars infrared radiation and the Mars albedo change. The research indicates that the influence are different when the spacecraft is at different orbital heights. There exists a critical orbit height. When the orbit height is less than the critical height, the influence is very large, and when it is great than this critical height, the influence could be ignored. This research provids a reference for the future Mars exploration. [ABSTRACT FROM AUTHOR]

Phase change materials (PCMs) can widely be used to absorb and release large amounts of latent heat at temperatures when the physical state changes. Heat storage systems depend mainly on the high latent heat density and small temperature intervals in PCMs during phase transition. However, there is a great leakage of current solid-liquid PCMs in the liquid phase, resulting from a large volume change above the melting point. Alternatively, the porous metal-organic frameworks (MOFs) have been investigated as solid support for a variety of storage purposes. A MOFs matrix material can also be expected to deal with the leakage of a shape-stabilized composite PCM in the most practical way. It is highly demanding for the extremely large surface area, large pore volume, and chemical tunability in the MOFs as the ideal matrix for PCMs. In particular, MOFs can also be designed for several aspects, such as pore shape and size, framework topology, and surface properties in the inner channels. A combination of fatty acids and porous MOF supports can be utilized to maintain the solid shape in the liquid PCM composite, where the phase change temperature of paraffin is within the range of normal human environments. Paraffin also presents high latent heat, suitable melting temperature range, non-corrosivity/non-toxicity, excellent chemical stability, and easy availability. The outstanding energy storage density and suitable phase change temperature also allow for the paraffin highly practical in the building materials. In this study, a facile solution impregnating approach was proposed to access a novel type of shape-stabilized PCM with metal-organic frameworks as the matrix. As such, a paraffin/MOF composite PCM was developed for heating storage, where paraffin was used as a phase change core, while Fe-MIL-101-NH2 was the supporting matrix. Solvent evaporation was finally conducted to successfully prepared 40 wt%~70 wt% paraffin/Fe-MIL-101-NH2 shape-stable phase change material (ss-PCM). Scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy were also conducted to characterize the morphology and structure of ss-PCM composites. Thermal gravimetric analysis (TGA) was used to determine the thermal stability, while differential scanning calorimetry (DSC) to the supercooling, the energy storage, and thermal cycle stability of ss-PCM. SEM images showed that the maximum loading of paraffin wax was 70%, mostly distributed in the interior and external core of Fe-MIL-101-NH2. XRD and FTIR showed that the paraffin wax and Fe-MIL-101-NH2 were physically combined in the ss-PCM. DSC analysis indicated that the highest energy storage capacity (51.3 J/g) was achieved in the 70 wt% paraffin/ Fe-MIL-101-NH2. In addition, there was no significant decrease in the thermal enthalpy of 70 wt% paraffin/Fe-MIL-101-NH2 (47.6 J/g) after 50 cycles, indicating an excellent heat cycle stability. Consequently, a novel paraffin/Fe-MIL-101-NH2 composite PCM can be expected to serve as the heat storage application. This finding can also provide a novel approach to access the shape-stabilized composite PCMs, which can potentially be extended to a variety of solid-liquid phase change materials. [ABSTRACT FROM AUTHOR]

新生儿高血压的发病率逐年升高。肾血管或肾实质疾病、心血管疾病（主动脉缩窄、动脉导管未闭）、肺部 疾病（气胸）及内分泌疾病（先天性肾上腺皮质增生症、高醛固酮血症、甲状腺功能亢进症）等可导致新生儿高血压。 新生儿高血压常无特异临床表现，出生１周内收缩压>95 mmHg或出生２～６周内收缩压≥105 mmHg即可明确诊 断新生儿高血压。新生儿高血压治疗前需进行病情评估，多数继发性新生儿高血压可随病因的改善消退。原发性 新生儿高血压的治疗方案主要依据高血压严重程度而定，轻度高血压患儿可定期监测血压，如高血压无法自发消 退，则可以使用噻嗪类药物（首选）或袢利尿剂进行治疗。中度高血压患儿没有终末器官受累者可用利尿剂（一线）、 肼屈嗪或普萘洛尔治疗. [ABSTRACT FROM AUTHOR]

The traditional BZ oscillating reaction experiment focuses on the imparting of dissipative structure knowledge and the measurement of the activation energy during the induction period. Based on the rich and colorful phenomena and the underlying philosophy of life presented by the concentric circle growth process, this case study innovatively designs the experimental content supported by the dissipative structure theory, introducing the concentric circle experiment content and the flipped learning model. It aims to enhance students’ scientific literacy and research abilities, guide students to analyze the safety hazards and potential environmental impacts in the experiment, integrate reflection on life into the experimental process, and utilize the principles of dissipative structures to understand and transform the world after class. The improved experiment will help establish students’ correct outlook on life and the world. [ABSTRACT FROM AUTHOR]

It proposed an improved artificial bee colony algorithm to better address the flexible job shop scheduling problem with the objective of minimizing the makespan. Firstly, it employed random selection and reverse learning strategies to enhance the quality of initial food sources. Simultaneously, it designed a novel feature representation method to calculate the distance between food sources. During the leading bee phase, it introduced cross-over and mutation strategies to optimize nearby food sources in the population. Moreover, in the exploring bee phase, it incorporate six variable neighborhood methods to expand the search space of solutions. Subsequently, in the scout bee phase, it eliminated local optima individuals based on the potential value of their food sources. This paper conducted extensive experiments on 15 datasets, and the results demonstrate that the performance of the proposed improved algorithm significantly outperforms that of four other well-known swarm intelligence optimization algorithms. This study provides a novel and effective approach for solving the flexible job shop scheduling problem with the goal of minimizing the makespan, holding important practical value for real-world production scheduling. [ABSTRACT FROM AUTHOR]

Objective To investigate the effects of Zuogui Jiangtang Shuxin (kidney-supplementing glucose-lowering heart-soothing) formula medicated plasma on ox-LDL-induced pyroptosis and apoptosis and to explore new targets in the treatmert of diabetic atherosclerosis with this formula. Methods SD rats were administered intragastrically with 7. 2 g/kg Zuogui Jiangtang Shuxin formula or 0. 83 g/kg metformin combined with 12. 45 mg/kg atorvastatin calcium to prepare drug-containing plasma. Zuogui Jiangtang Shuxin formula medicated plasma was then extracted for J774A. 1 cells treatment. J774A. 1 cells were pretreated with ox-LDL to establish the experimental model of pyroptosis and apoptosis. CCK-8 essay was used to meausre the effect of medicated plasma or ox-LDL on proliferation of J774A. 1 cells and to determine the optimal concentration. J774A. 1 cells were randomly divided into 4 groups: normal group, model group, Zuogui Jiangtang Shuxin medicated plasma group and Western medicine combination (metformin + atorvastatin calcium) medicated plasma group. After inducting and administration for 24 hours, LDH releasing test was used to evaluate the cell membrane integrity. Cell apoptosis were measured by using flow cytometry. The expression of NLRP3, Caspase-1, GSDMD, Capase-3 and Bax were detected by using Western blot assay. Results 10% medicated plasma and blank plasma showed no inhibition of cells, the concetnration of which was chosen to be suitable for experiment. The cell survival rate decreased when J774A. 1 cells were treated with 100 mg/L ox-LDL for the induction concentration. Compared with the blank group, 100 mg/L ox-LDL suppressed the growth of J774A. 1 cells. It was also shown with LDH releasing test that LDH activity and apoptosis rate increased in the model group cells significantly (P <0. 01). Moreover, ox-LDL could up-regulate the expression of NLRP3, Caspase-1, GSDMD, Ca$pase-3 and Bax in the model group (P <0. 01). Compared with the model group, Zuogui Jiangtang Shuxin medicated plasma reduced inhibition rate, LDH release and the rate of apoptosis (P <0, 01). Meanwhile, the expression of pyroptosis related protein (NLRP3, Caspase-1 and GSDMD) and apoptosis related protein Caspase-3 and Bax expression were significantly reduced(P <0. 01). These effects were significantly superior to Western medicine combination group (P <0,01). Conclusiail Zuogui Jiangtang Shuxin formula medicated plasma can maintain the function of J774A. 1 cells, and its mechanism may be related to the inhibition of pyroptosis and apoptosis induced by ox-LDL. [ABSTRACT FROM AUTHOR]

Objective To explore the active components, core targets and mechanism of Kidney-qi pill in treating for Type 2 diabetes mellitus (T2DM), based on network pharmacology and preliminarily verify it through in vitro experiment. Methods The TCM database @ Taiwan, Chemistry Database and TCMSP database were used to filter the chemical composition and target of Kidney-qi pill. The corresponding gene name of each target was obtained in UniProt database. Then, the target genes of Kidney-qi pill and T2DM were plotted, depending on the relationship between chemical composition and target. The String software was used to construct Kidney-qi pill ingredients-targets network. The DAVID database was used to analyze the pathway enrichment of the interaction gene, and core signaling pathways were performed by using KEGG pathway analysis tool. Insulinoma cell line INS-1 cells in rats were used to establish damage model by using high concentration of glucose. SD rats were administered intragastrically with 8. 64 g/kg Kidney-qi pill to prepare medicated plasma, which was then extracted for INS-1 cells experiment. The growth inhibition was tested by using CCK-8 essay. Key signal pathways were validated by using Western blot assay. Results 58 chemical composition of Kidney-qi pill were analyzed. A total of 198 human target genes related to T2DM were obtained. The network analysis indicated that Kidney-qi pill can treat T2DM by regulating AKT1, JUN, TNF and PTGS2 targets, involving phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) signaling pathway, mitogen-activated protein kinase (MAPK) signaling pathway, tumor necrosis factor (TNF) signaling pathway, Neuroactive ligand-receptor interaction and hypoxia inducible factor-1 (HIF-1) signaling pathway. Kidney-qi pill medicated plasma significantly promoted the proliferation of INS-1 cells, and apparently increased the expression of PI3K, AKT and p- AKT (P <0, 01). There was no significant difference in Kidney-qi pill medicated plasma group and 740 Y-P group (P〉0. 05), Conclusiail Kidney-qi pill contains herbs of the same or different active ingredients, and this prescription can effectively treat T2DM. Based on the network pharmacology, Kidney-qi pill can promote cell signal transduction, regulate mitochondrial function and energy metabolism. The experiments have confirmed that Kidney-qi pill can affect the expression of PI3K/AKT pathway related proteins. This research can provide theoretical basis for further experiments and clinical application. [ABSTRACT FROM AUTHOR]

T he construction of efficient heterogeneous Fen ton-like catalytic system is the key to sewage treatment. In this study, a paper-based immersion catalyst ( MnO2 / CH-FP) was prepared by alkali-oxidation on cellulose filter paper (FP) cross-linked with chitosan (CH ) . SEM, XRD, FT-IR and TGA were used to characterize its properties. Its catalytic performance in methylene blue ( MB) heterogeneous Fenton-like degradation reaction was studied. T he effects of pH value, catalyst dosage, initial MB concentration and amount of H2O2 on the degradation efficiency of MB were investigated. The results showed that under the optimal conditions, MB (10 mg/L) could be degraded 100 % within 60 min. In addition,MnO2 / C H - FP can be easily separated from the reaction system and can be reused for four cycles after a simple cleaning without significantly reducing the catalytic activity. [ABSTRACT FROM AUTHOR]

A method was developed for the determination of phenamacril residue in four kinds of cereals (rice, wheat, sorghum, corn) by QuEChERS combined with gas chromatography-mass spectrometry (GC-MS). The samples were extracted with acetonitrile, cleaned-up with PSA, concentrated, and detected by GC-MS using internal standard method. The results showed that the linear relationship of phenamacril in the linear range from 10 to 500 μg/L was good, the linear correlation coefficients (R2) was higher than 0.998 3, with the limit of quantitation (LOQs) lower than 0.005 mg/kg. The average recoveries at four spiking levels (0.005 mg/kg, 0.02 mg/kg, 0.05 mg/kg, 0.1 mg/kg) in cereals ranged from 85% to 108%, and the relative standard deviations (RSDs) were from 1.1% to 10.4%. This method was simple, rapid, sensitive and applicable to the determination of phenamacril in cereals. [ABSTRACT FROM AUTHOR]

BACKGROUND: Studies have found that single nucleotide polymorphism genotypes in the HTRA1 gene promoter region are associated with intervertebral disc degeneration, while HAPLN1 is associated with osteoarthritis caused by intervertebral disc degeneration. OBJECTIVE: To explore the role of human secretory serine protease HTRA1 and the key group of extracellular matrix HAPLN1 in the pathogenesis of intervertebral disc degeneration. METHODS: This study included 498 postmenopausal female subjects who underwent a physical examination at Dingzhou People’s Hospital from April 2015 to December 2018. TaqMan PCR was used to detect HTRA1 gene promoter rs11200638 single nucleotide polymorphism and HAPLN1 gene 5' flanking rs975563, intron 1 rs10942332, intron 2 rs179851 and intron 4 rs4703570 single nucleotide polymorphism in 498 postmenopausal Chinese women. The correlation between the HTRA1orHAPLN1 gene polymorphisms and the radiographic features of spinal disc degeneration was analyzed. The trial has been approved by the Ethics Committee of Dingzhou People’s Hospital. RESULTS AND CONCLUSION: Among the 498 subjects with the HTRA1 gene rs11200638 single nucleotide polymorphism, 178 were GG homozygotes, 222 were GA heterozygotes, and 98 were AA homozygotes. We compared the parameters of intervertebral disc degeneration in subjects with at least one G allele (GG+GA, n=400) and without G allele (AA, n=98). In HTRA1 gene rs11200638 single nucleotide polymorphism, the score on intervertebral space stenosis in the subjects with GG+GA allele genome was lower than that in the subjects with AA allele (P < 0.001). With the increase of the score on intervertebral space stenosis, the proportion of the subjects with AA alleles increased (P ≤ 0.001). Among the 498 subjects with single nucleotide polymorphisms of the HAPLN1 gene, 137 were homozygous for TT, 230 were heterozygous for CT, and 131 were homozygous for CC. Intervertebral disc degeneration parameters of CC+TT allele (n=361) and TT allele (n=137) were compared. In the HAPLN1 gene, there was a significant difference between the CC+TT and TT alleles of the rs179851 single nucleotide polymorphism in osteophyte formation and intervertebral space stenosis (P < 0.01). Among the HAPLN1 gene rs179851 single nucleotide polymorphisms, the proportion of subjects with TT alleles and intervertebral space stenosis ≥ 6 points increased (P < 0.05). With an increase in osteophyte formation score, the proportion of subjects with TT allele increased (P < 0.001). These results reveal that HTRA1 and HAPLN1 genetic variations at specific genetic loci are associated with intervertebral disc degeneration. [ABSTRACT FROM AUTHOR]

多囊卵巢综合征(PCOS)是一个多因素、复杂的内分泌代谢性疾病,常见的临床表现包括月经不规律、高雄激素相关表现、排卵障碍性不孕等,可同时伴有胰岛素抵抗(IR)、高胰岛素血症、脂代谢异常等。PCOS发病呈逐年上升趋势,青春期PCOS发病率明显升高,其近、远期不良结局严重影响女性的生殖健康。目前,PCOS尚无有效的治愈方法,临床以对症治疗为主,但因其临床表现高度异质,临床上对于PCOS的治疗方式尚不统一。该文就青春期及育龄期PCOS最新治疗进展予以综述,为临床医生规范化治疗PCOS提供依据. [ABSTRACT FROM AUTHOR]

Objective　To study the efficacy and safety of rivaroxaban after stent implantation of the femoral popliteal atherosclerosis occlusion stent. Methods　Eighty-seven patients who met the criteria were randomly divided into 45 cases in the treatment group and 42 cases in the control group. There was no statistically significant difference in the general information between the two groups. The treatment group was given rivaroxaban tablets 10 mg each time， po， qd and aspirin enteric-coated tablets 100 mg each time， po， qd； the control group was given aspirin enteric-coated tablets 100 mg， po， qd each time， both groups were given Atorvastatin 10 mg， po， qd and Beraprost sodium tablets 40 μg， po， tid， all patients were urged to quit smoking. Observe the relevant efficacy indicators such as ABI， claudication distance， stent restenosis， stent mural thrombosis， and secondary intervention rate of the two groups of patients on the day of postoperative day，3 months and 6 months after treatment， and the safety indicators such as adverse drug reactions， major adverse cardiac and cerebrovascular events， minor and major bleeding， the results were analyzed statistically. Results　At 6 months， there were differences in the stent mural thrombosis， ankle brachial index and claudication distance between the two groups （P < 0.05）， no significant difference in in-stent restenosis （P > 0.05），There was no statistically significant difference in the logrank test of the second intervention rate between the two groups （P > 0.05），and there was no statistical difference in safety comparison between the two groups（ P > 0.05） . Conclusion　Rivaroxaban combined with aspirin can significantly reduce stent mural thrombosis and delay the decline in postoperative ABI and claudication distance， which may benefit the long-term prognosis of patients. [ABSTRACT FROM AUTHOR]

Objective : To explore the operative time of interventional embolization and the influencing factors of prognosis in patients with intracranial aneurysm. Method : 130 patients with intracranial aneurysm who were admitted to Fuyang Hospital Affiliated to Anhui Medical University and the First Affiliated Hospital of Anhui Medical University from May 2015 to may 2017 were selected, they were treated with interventional embolization. The patients were divided into early group (n=78) and delayed group (n=52) according to the operative time. The early group was operated within 3 days after the onset of the disease, and the delayed group was operated after the onset of the disease>3 days. The degree of arterial embolism, complications and prognosis within 2 years were compared between the two groups. According to the prognosis, the patients were divided into the good group and the bad group. Multivariate logistic regression was used to analyze the influencing factors of patients' prognosis. Results : The complete embolism rate of early group was 88.46%, which was higher than 73.08% of delayed group, the difference was statistically significant (P<0.05). There were no significant differences between the two groups in the incidence of aneurysm hemorrhage, limb disorder, consciousness disorder, infection at puncture site, hydrocephalus and electrolyte disorder (P>0.05). The good prognosis rate of early group was 79.49%, which was significantly higher than 63.46% of delayed group (P<0.05). Bad group of preoperative Glasgow outcome scale (GOS)≤ 3 points, delay surgery, tumors located in the posterior circulation, hypertension, diabetes, Hunt-Hess grade 3~5, Fisher grade Ⅲ~Ⅳ proportion were significantly higher than those of the good group (P<0.05). Multivariate logistic regression analysis showed that GOS score≤ 3 before operation, delayed operation, tumor location in the posterior circulation, hypertension, diabetes, hunt Hess grade 3-5, Fisher grade Ⅲ-Ⅳ were the influencing factors of poor prognosis (P<0.05). Conclusion : Early interventional embolization can improve the complete embolization rate and prognosis of patients with intracranial aneurysm. The poor prognosis are mainly related to preoperative GOS score, operative time, tumor location, hypertension, diabetes, hunt Hess grade and Fisher grade. [ABSTRACT FROM AUTHOR]