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The work behind this paper takes place in the EFDA's European Goal Oriented Training programme on Remote Handling (RH) “GOT-RH”. The programme aims to train engineers for activities supporting the ITER project and the long-term fusion programme. One of the projects of this programme focuses on the verification and validation (V&V) of ITER RH system requirements using digital mock-ups (DMU). The purpose of this project is to study and develop efficient approach of using DMUs in the V&V process of ITER RH system design utilizing a System Engineering (SE) framework. Complex engineering systems such as ITER facilities lead to substantial rise of cost while manufacturing the full-scale prototype. In the V&V process for ITER RH equipment, physical tests are a requirement to ensure the compliance of the system according to the required operation. Therefore it is essential to virtually verify the developed system before starting the prototype manufacturing phase. This paper gives an overview of the current trends in using digital mock-up within product design processes. It suggests a simulation-based process design centralized around a simulation lifecycle management system. The purpose of this paper is to describe possible improvements in the formalization of the ITER RH design process and V&V processes, in order to increase their cost efficiency and reliability. [ABSTRACT FROM AUTHOR]