1. Insights into the Mechanisms of Action of MDA-7/IL-24: A Ubiquitous Cancer-Suppressing Protein.
- Author
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Modi, Jinkal, Roy, Abhishek, Pradhan, Anjan K., Kumar, Amit, Talukdar, Sarmistha, Bhoopathi, Praveen, Maji, Santanu, Mannangatti, Padmanabhan, Sanchez De La Rosa, Daniel, Li, Jiong, Guo, Chunqing, Subler, Mark A., Windle, Jolene J., Cavenee, Webster K., Sarkar, Devanand, Wang, Xiang-Yang, Das, Swadesh K., Emdad, Luni, and Fisher, Paul B.
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CELL death , *CANCER patients , *ANTINEOPLASTIC agents , *TUMOR growth , *PROTEINS - Abstract
Melanoma differentiation associated gene-7/interleukin-24 (MDA-7/IL-24), a secreted protein of the IL-10 family, was first identified more than two decades ago as a novel gene differentially expressed in terminally differentiating human metastatic melanoma cells. MDA-7/IL-24 functions as a potent tumor suppressor exerting a diverse array of functions including the inhibition of tumor growth, invasion, angiogenesis, and metastasis, and induction of potent "bystander" antitumor activity and synergy with conventional cancer therapeutics. MDA-7/IL-24 induces cancer-specific cell death through apoptosis or toxic autophagy, which was initially established in vitro and in preclinical animal models in vivo and later in a Phase I clinical trial in patients with advanced cancers. This review summarizes the history and our current understanding of the molecular/biological mechanisms of MDA-7/IL-24 action rendering it a potent cancer suppressor. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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