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We present in this paper a novel proactive interference avoidance scheme for mobile-to-mobile (M2M) communication as an underlay in Long-Term Evolution (LTE) downlink networks. The proposed scheme introduces an intelligent user-selective resource allocation algorithm that aims to proactively avoid interference between M2M pairs and LTE regular users while achieving a satisfactory link budget for both M2M and LTE regular links. The proposed resource allocation algorithm is based on a novel low-complexity interference estimation approach that requires only channel quality indicator (CQI) information (CSI). Since the CQI reporting mechanism has been already implemented in current LTE systems, the proposed algorithm is indeed practical and standard compatible, compared with the existing works that require perfect knowledge of the channel state information (CSI). In this research, achievable data throughput with LTE-compliant adaptive modulation and coding has been adopted as the optimization measurement, rather than the information-theoretic capacity. Therefore, the performance of the proposed scheme is practically realizable in LTE communication systems. Since the performance of the proposed scheme highly relies on the accuracy of CQI feedback, we also carry out performance analysis to evaluate the impact of CQI estimation error and delay. The simulation results show that the total achievable data throughput for LTE networks is dramatically enhanced by M2M communication with this proposed interference avoidance resource allocation scheme. [ABSTRACT FROM PUBLISHER]