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The use of volatile solvents for organic synthesis is nowadays questioned due to their negative impact on the environnement. To develop sustainable and environmentally friendly methodologies, we propose to combine two green chemistry concepts: the use of bioinspired solvents: natural deep eutectic solvents (NaDES), and mechanochemistry. Using the Suzuki‐Miyaura coupling as a model reaction, we described an efficient mechanochemical method with NaDES as a LAG (liquid‐assisted grinding) additive with short reaction times and without any ligand or additional heating. A mechanochemical extraction was also used to reduce the amounts of extraction solvents and the total time of the synthesis process. [ABSTRACT FROM AUTHOR]

Multicomponent reactions are crucial for operating organic synthesis. In today's world, chemists concentrate on greener methodologies that cater to rising environmental concerns. Most conventional organic solvents are harsh on the environment, which can be addressed by environmentally and pocket‐friendly Deep eutectic solvents (DES). Organic synthesis via MCR in the presence of DES has resulted in the blend of green methodology and green solvent for organic transformations. Forasmuch as addressing the environmental concerns and developing higher heterocycles, our review focuses on the literature published on the DES‐mediated Multicomponent synthesis of N‐Heterocyclic compounds. [ABSTRACT FROM AUTHOR]

Front Cover: FeIII-Based Eutectic Mixtures as Multi-task and Reusable Reaction Media for Efficient and Selective Conversion of Alkynes into Carbonyl Compounds (Chem. Eur. J. 57/2023) Keywords: alkynes; atom economy; deep eutectic solvents; FeCl3-mediated organic synthesis; hydration EN alkynes atom economy deep eutectic solvents FeCl3-mediated organic synthesis hydration 1 1 1 10/18/23 20231013 NES 231013 B Thanks to the use b of a sustainable Fe SP III sp -based deep eutectic solvent ( I DES i ) as promoter/reaction medium, alkynes were hydrated under bench-type reaction conditions (45 °C, air, absence of co-catalysts or co-solvents). Alkynes, atom economy, deep eutectic solvents, FeCl3-mediated organic synthesis, hydration. [Extracted from the article]