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• A high-resolution integrated assessment framework for estimating future watershed ecosystem services was proposed under the latest SSP-RCP scenarios; • The spatial–temporal dynamics on water-related ESs of the PRB were projected under the SSP-RCP scenarios; • The main driving factors affecting the spatial–temporal heterogeneity of water-related ESs of the PRB were identified under the SSP-RCP scenarios. The projection of future ecosystem service (ES) dynamics under SSP-RCP scenarios would be beneficial for the development of effective climate mitigation strategies for policymakers. However, current projection frameworks generally neglect the downscaling of high-resolution climate and land use data, leading to uncertainties in the simulation of ESs under the SSP-RCP scenarios. To address this issue, this study proposes an integrated analysis framework to downscale climate and land use data. We first identified areas of high risk in terms of inadequate water-related ESs in the Pearl River Basin (PRB) of China. Subsequently, we analyzed key socio-environmental factors driving the dynamics of water-related ESs under future SSP-RCP scenarios. The results indicate that 1) water-related ESs in the PRB are expected to show an overall increasing trend, 2) the sub-watersheds located in the downstream is at a higher risk of experiencing insufficient supply capacity for water-related ESs, and 3) under the coupling effects of climate change, land use change, and socio-economic development, drastic changes in future land use are expected to have a stronger impact on watershed ESs than the climate (i.e., global warming). Our work provides valuable insights for policymakers and managers regarding future water and land resource planning. The proposed framework can be integrated with other hydrological or land surface models to project the spatial–temporal evolution characteristics of future watershed ESs with finer temporal resolution. [ABSTRACT FROM AUTHOR]