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In the ulcer wounds of diabetic foot patients, excessive matrix metalloproteinase-9 (MMP-9) is the main indicator for predicting the occurrence of diabetic foot and the difficulty of foot ulcer. The possible mechanisms include: high level of MMP-9 reduces VEGF expression and inhibits fibroblast formation. The biological behavior of the cells affects diabetic foot ulcer (DFU) healing; the imbalanced MMP-9/TIMP-1 ratio affects DFU healing. Selective MMP-9 inhibitors (including small molecule inhibitors, advanced wound adjuvant inhibitors, RNA inhibitors based on interfering gene level expression) can be used as a means of promoting DFU healing, but large-sample, multicenter randomized controlled trials are still needed. Long-term follow-up further verified the efficacy and safety. The literature related to MMP-9 and DFU in recent years was reviewed and summarized. To review the effects of MMP-9 on the healing of DFU and its mechanism. [ABSTRACT FROM AUTHOR]

Objecctive: To observe the clinical curative effect of Sun's abdominal-acupuncture on generalized anxiety disorder (GAD). Method: Sixty patients meeting the inclusion criteria were randomly divided into two groups. The experimental group was treated with abdominal area-1 and abdominal area-8 of Sun's abdominal-acupuncture, and conventional acupuncture. The control group was treated with conventional acupuncture. The score was recorded before the treatment, after one week's treatment, after two weeks' treatment, after three weeks' treatment for the evaluation of the therapeutic effect. Results: Hamilton reductive ratio was taken to measure the results of this methods. Hamilton reductive ratio evaluates the results: the total effective rate of experimental group after three weeks treatment was 93.33 %, the rate of control group after three weeks treatment was 80.00 %. Statistical analysis showed that there was a significant difference between the two groups (P＜0.05). Conclusion: Treatment by abdominal area-1 and abdominal area-8 of Sun's abdominal- acupuncture of generalized anxiety disorder with liver-qi stagnation syndrome is more effective than conventional acupuncture alone, and the patient's condition has improved significantly; treatment by Sun's abdominal-acupuncture can significantly improve mental anxiety and has more advantages than conventional acupuncture alone. [ABSTRACT FROM AUTHOR]

With the help of information visualization tools, this paper makes a visual analysis of the relevant literatures in the field of TCM talent cultivation collected by CNKI (China Knowledge Resource Base) based on the sample data of the documents published during the construction time of China KnowledgeNet-December 31, 2017, and analyses the composition of the research subjects of TCM talent cultivation by drawing up the distribution of the authors, institutions and funds of the literatures. Key words co-occurrence atlas and word frequency and centrality are used to analyze the research topics and hotspots of TCM personnel training in China. The purpose is to show the current situation, research hotspots and future research trends of TCM personnel training in China intuitively, so as to identify and explore the basic trend and overall development context of TCM personnel training in China. [ABSTRACT FROM AUTHOR]