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Due to increasing traffic demand, many metropolitan areas are experiencing extensive traffic congestion, which demands for efficient traffic signal timing and optimization. However, conventional efficiency measure-based signal optimization cannot handle the ubiquitous uncertainty in the road networks, demanding for the incorporation of reliability measures into signal optimization, which is still in its early stage. Therefore, targeting this issue, based on the recent studies on recognizing travel time reliability (TRR) as an important reliability measure of road networks, a travel time reliability-based urban road traffic network signal timing optimization model is proposed in this paper, with the objective function to optimize a TTR measure, i.e., buffer time index. The proposed optimization model is solved using the heuristic particle swarm optimization approach. A case study is conducted using microscopic traffic simulation for a road network in the City of Nanjing, China. Results demonstrate that the proposed optimization model can improve travel time reliability of the road traffic network and the efficiency of the road traffic network as well. Future studies are recommended to expand the integration of travel time reliability into traffic signal timing optimization. [ABSTRACT FROM AUTHOR]