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Importance: The measurement of laboratory biomarkers plays a critical role in managing patients with COVID-19. However, to date most systematic reviews examining the association between laboratory biomarkers and mortality in hospitalized patients early in the pandemic focused on small sets of biomarkers, did not account for multiple studies including patients within the same institutions during overlapping timeframes, and did not include a significant number of studies conducted in countries other than China. Objective: To provide a comprehensive summary and an evidence map examining the relationship between a wide range of laboratory biomarkers and mortality among patients hospitalized with COVID-19 during the early phase of the pandemic in multiple countries. Evidence review: MEDLINE, EMBASE, and Web of Science were searched from Dec 2019 to March 9, 2021. A total of 14,049 studies were identified and screened independently by two raters; data was extracted by a single rater and verified by a second. Quality was assessed using the Joanna Briggs Institute (JBI) Case Series Critical Appraisal tool. To allow comparison across biomarkers, standardized mean differences (SMD) were used to quantify the relationship between laboratory biomarkers and hospital mortality. Meta-regression was conducted to account for clustering within institutions and countries. Results: Our systematic review included 94 case-series studies from 30 countries. Across all biomarkers, the largest and most precise SMDs were observed for cardiac (troponin (1.03 (95% CI 0.86 to 1.21)), and BNP/NT-proBNP (0.93 (0.52 to 1.34)), inflammatory (IL-6 (0.97 (0.67 to 1.28) and Neutrophil-to-lymphocyte ratio (0.94 (0.59 to 1.29)), and renal biomarkers (blood urea nitrogen (1.01 (0.79 to 1.23)) and estimated glomerular filtration rate (-0.96 (-1.42 to -0.50)). There was heterogeneity for most biomarkers across countries with studies conducted in China generally having larger effect sizes. Conclusions and relevance: The results of this study provide an early pandemic summary of the relationship between biomarkers and mortality in hospitalized patients. We found our estimated ESs were generally attenuated compared to previous systematic reviews which predominantly included studies conducted in China. Despite using sophisticated methodology to examine studies across countries, heterogeneity in reporting of case-series studies early in the pandemic limits clinical interpretability. [ABSTRACT FROM AUTHOR]

China-Pakistan Economic Corridor (CPEC) has become a "game-changer" not only for policymakers but also for common citizens of China and Pakistan because of its potential benefits in the economic prosperity and sustainable development in the lives of individuals. Recently, scholars have shown a great interest in researching the eminence of CPEC. Despite prodigious efforts of scholars, the question "how CPEC would influence living standards of rural women and what they perceive?" has been remained unanswered. The present study is the first attempt to unearth the perceptions of rural areas' women towards CPEC. We collected empirical evidence through a structured questionnaire from 302 educated rural women and interviewing 32 uneducated rural women. The following major conclusions are drawn through structural equation modeling via AMOS 21: the rural women significantly directly perceive new opportunities through CPEC; however, they perceive that the CPEC would not directly influence their quality of life and self-enhancement, but through the development of these rural areas. Rural development partially mediates the relationship between CPEC development and perceived opportunities while it fully mediates the relationships between CPEC development and quality of life as well as between CPEC development and self-enhancement. Policymakers need to emphasize on development of rural areas that would improve living standards of poor communities. The government needs to meet the expectations of poor communities and rural women to ensure their sustainable development. [ABSTRACT FROM AUTHOR]