1. Fluindione and drug reaction with eosinophilia and systemic symptoms: an unrecognised adverse effect?
- Author
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Daveluy, Amélie, Milpied, Brigitte, Barbaud, Annick, Lebrun-Vignes, Bénédicte, Gouraud, Aurore, Laroche, Marie-Laure, Ciobanu, Ecaterina, Bégaud, Bernard, Moore, Nicholas, Miremont-Salamé, Ghada, and Haramburu, Françoise
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ANTICOAGULANTS , *DATABASES , *DRUG allergy , *DRUG eruptions , *DRUG side effects , *EOSINOPHILIA , *HEALTH outcome assessment , *VITAMIN K , *TREATMENT effectiveness , *CHEMICAL inhibitors - Abstract
Purpose: Fluindione is an oral vitamin K antagonist (indanedione derivative) exclusively marketed in France and Luxembourg, known to have immuno-allergic adverse effects such as hepatitis, fever or interstitial nephritis. A few cases of drug reaction with eosinophilia and systemic symptoms (DRESS) have been reported with fluindione. The aim of the present study was to investigate fluindione-induced DRESS cases reported in France and to describe their characteristics. Methods: We searched for potential cases of DRESS with fluindione reported in the French pharmacovigilance database since 2000. Results: Thirty-six cases of DRESS were included and concerned 17 women and 19 men. The mean age was 65 years (median: 68 years, range: 28-95 years). Kidneys and liver were the most frequent organs involved. Thirty-five cases were serious. In 5 cases, the effect was life-threatening. Most of the patients recovered. Fluindione was the only medicine suspected in 26 cases. Skin patch tests, performed in 10 cases, were positive with fluindione in 9 cases. Conclusions: Fluindione is not known to be a frequent cause of DRESS. However, the number of reports found is probably underestimated. The seriousness of DRESS, as all immuno-allergic adverse effects, contraindicates fluindione reintroduction. Coumarinic derivatives are the alternatives in patients who need oral anticoagulant treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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