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The Study to Explore Early Development (SEED) is a multi-site case-control study designed to explore the relationship between autism spectrum disorder (ASD) phenotypes and etiologies. The goals of this paper are to (1) describe the SEED algorithm that uses the Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS) to classify children with ASD, (2) examine psychometric properties of different ASD classification methods, including the SEED method that incorporates rules for resolving ADI-R and ADOS discordance, and (3) determine whether restricted interests and repetitive behaviors were noted for children who had instrument discordance resolved using ADI-R social and communication scores. Results support the utility of SEED criteria when well-defined groups of children are an important clinical or research outcome. [ABSTRACT FROM AUTHOR]

Parametric and nonparametric approaches to evaluate land-cover change detection using very high resolution (VHR) satellite imagery are applied to the analysis of the demolition of the Rocky Flats nuclear weapons facility located near Denver, CO. Both maximum-likelihood and neural network classifiers are used to validate a new parallel architecture which improves the accuracy when applied to VHR satellite imagery for the study of land-cover change between sequential satellite acquisitions. An enhancement of about 14% was found between the single-step classification and the new parallel architecture, confirming the advantage and the robust improvement obtained with this architecture regardless of the classification algorithm used. In this paper, we demonstrate and document the demolition and removal of hundreds of buildings taken down to bare soil between 2003 and 2005 at the Rocky Flats site. [ABSTRACT FROM AUTHOR]