1. Circulating Matrix Metalloproteinase-28 Levels Are Related to GRACE Scores and Short-Term Outcomes in Patients with Acute Myocardial Infarction.
- Author
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Zhou, Ke, Li, Yuanmin, Xu, Yawei, and Guo, Rong
- Subjects
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AGE distribution , *BIOMARKERS , *HOSPITAL care , *MULTIVARIATE analysis , *MYOCARDIAL infarction , *RISK assessment , *DISCHARGE planning , *PROPORTIONAL hazards models , *KAPLAN-Meier estimator , *MATRIX metalloproteinases ,MYOCARDIAL infarction-related mortality ,MORTALITY risk factors - Abstract
Objective. To investigate the relationship between the level of matrix metalloproteinase-28 (MMP-28) in patients with acute myocardial infarction (AMI) and the global registry of acute coronary events (GRACE) scores as well as their short-term prognosis. Methods. Two hundred eleven patients with AMI were enrolled, and their basic clinical characteristics were collected for determining the GRACE score. We measured the plasma levels of MMP-28 and other biomarkers in the study population. The association of MMP-28 levels with cardiac events and cardiac deaths occurring within 30 days of discharge was evaluated with multivariable Cox proportional hazard models. Results. The MMP-28 levels were significantly higher in patients with acute ST-elevation myocardial infarction (STEMI) than in patients with non-ST-elevation myocardial infarction (NSTEMI) (P < 0.01). Correlation analysis showed that the level of MMP-28 was positively correlated with the GRACE score in patients with AMI ( R 2 = 0.366 , P < 0.05). Cox multivariate regression results showed that MMP-28 was associated with cardiovascular events during the hospitalization and 30 days after discharge (P < 0.01). In addition, Kaplan–Meier analysis showed that cardiac events and deaths were significantly higher in patients with MMP- 28 ≥ 1.21 ng/mL (all P < 0.01). Conclusion. There is a correlation between the plasma MMP-28 level and GRACE score in patients with AMI. MMP-28 is also associated with cardiovascular events and cardiovascular deaths during the hospitalization of patients and within 30 days of discharge. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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