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Objective: To determine and disclose publications from Turkey that have contributed most \"genuinely\" to medicine in the past 40 years. Method: Based on data from the Web of Science, 100 publications originating from Turkey's institutions were identified as having received by June, 2011, the greatest number of citations. Papers having more than a minor share by international authors were excluded. Results: Eighty-three primary authors generated 100 medical papers, each receiving>82 (95% GA 83; 230) citations. These articles, cited herein, were in the top 1% to 6% papers in the world. Half of the articles were published in 1994-2002. An estimated 10-12 such highly cited papers are produced currently in Turkey annually which represent only a global share of 0.5 per mille. The rate of rise registered in the period 1995-2005 may be anticipated not to persist later. Internal medicine, led by rheumatology, hematology and cardiology, and neurosciences were represented above the average. Health issues encountered more widely than in other populations, headed by Behçet's disease, were the most frequent topics. Conclusion: Results are unsatisfactory compared with the potential of Turkey. A concerted and much greater effort is needed to rebuild an environment that focuses on promoting research with a potential for contributing to medicine [ABSTRACT FROM AUTHOR]

Although the importance of long-term prophylactic treatment is certain in bipolar disorder, there is stil debate on how to which patients and evaluate the treatment response. Efficacious long-term treatment can reduce morbidity and mortality significantly and improve quality of life of bipolar patients. The concept of ideal response should also be defined very clearly in order to discuss the difficulties of measuring the effectiveness of the prophylactic treatment. The aims of this paper are to determine whether our currently methods and criteria are valid, reliable and sensitive evaluating the efficacy of the treatment response and to briefly inform the clinicians about the drugs used in pharmacologic prophylaxis in accordance with relevant data. [ABSTRACT FROM AUTHOR]