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This paper analyses Latin America's role in an international system in flux, with high levels of uncertainty and transformations that signal a shift in the geoeconomic and geopolitical landscape across the world. Against this backdrop, the paper examines the challenges (both old and new) the region must face, focusing on the impact of global changes on regional dynamics and the capacity of the different countries to find answers both to the international situation and old and new internal problems. In addition, as an introductory paper to this monograph entitled "Geopolitics from Latin America: a change of cycle and multipolarity", it identifies the fulcrums of these changes, their impact, the main actors involved and the processes underway. [ABSTRACT FROM AUTHOR]