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This paper aims to debate the new paradigms of international development aid, with a specific focus on the Millennium Development Goals (MDGs) and their implementation within the context of Latin America. The paper will start drawing both the conceptual framework and the international environment, and afterwards will provide readers with an analysis of a success story occurred in the Department of Antioquia (Colombia). A further analytical approach will be proposed to appraise the potential of the North-South and South-South developmental co-operations. These may be linked one to each other with the first strengthening and widening up the second, thus creating innovative enabling environments for fruitful exchanges between local actors and organized civil societies of the North and the South of the world. [ABSTRACT FROM AUTHOR]