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Cytomegalovirus can affect people of all ages, from all geographical areas, regardless their race or the social status. The severity of infection fluctuates from easy to severe, in most cases being asymptomatic. The antiviral therapy is rarely administered, only in selected cases and consists in ganciclovir or sometimes valganciclovir. Most of the patients do not present long-term sequelae from the infection, but for premature infants and children with very low birth weight, complications may occur more frequently than in the general population. We present the case of an infant of three months, diagnosed with cytomegalovirus hepatitis after corroborating clinical data, laboratory and ultrasound results. Evolution is initially favorable towards healing without suggesting the possibility of long-term organ injuries, but after four months, the infant is readmitted to the hospital and is diagnosed with biliary atresia. [ABSTRACT FROM AUTHOR]