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The treatment of ulcerated lesions of the oral cavity is usually carried out using topical analgesic drugs, anti-inflammatory corticosteroids, and alcohol-free oral antiseptics. The topical use of 0.05% Clobetasol Propionate in aqueous solution for ulcerated lesions in the oral cavity is little publicized nationally and little mentioned in scientific studies regarding its effectiveness, lesion regression time, and adverse effects. Therefore, the objective of this study was to retrospectively evaluate the medical records of patients who were treated for ulcerated or erosive lesions, using Clobetasol Propionate 0.05%, in the stomatology clinic of an institution to investigate its effectiveness. Medical records of patients who presented the fundamental ulcerated alteration and made topical use of 0.05% Clobetasol Propionate were selected. An examiner selected the sample following the inclusion and exclusion criteria and performed the retrospective analysis. The types of information collected were age, gender, diagnosis of the disorder, amount of injury, time of use, the evolution of the injury, exact time of regression, and presence of adverse reactions. A total of 17 medical records were included, of which five were from patients with erosive lichen planus lesions, three traumatic ulcers, three lichenoid lesions, two multiform erythema, one lactose allergy, one cold sore, and one scaly gingivitis. All cases had their symptoms solved, but, in six cases, the clinical changes remained, although milder and asymptomatic. No adverse reaction was noted in the medical record. The statistical analysis showed no association in relation to gender (Fisher's exact test; p = 0.49; p> 0.05). There was no statistically significant difference in the frequency of injuries (Fisher's exact test; p = 0.85; p> 0.05). The use of 0.05% Clobetasol Propionate, prescribed for up to five days, proved effective in treating ulcerated lesions of the oral mucosa, mainly for symptomatic relief. Furthermore, it revealed no adverse effects. [ABSTRACT FROM AUTHOR]

Objectives - To understand the relationship between plantar pressures and the ulcers' occurrence in individuals with neuropathic diabetic foot, using this factor as a possible method of risk assessment and identification. To investigate the association between the epidemiological data and the ulcer's occurrence. To identify an indicative value for its occurrence. Methods - A quantitative cross-sectional, correlational, and epidemiological study was carried out by collecting sociodemographic and clinical information from the participants and conducting sensitivity tests to identify neuropathy. The sample (N = 60) was divided into two groups: neuropathic diabetics and non-neuropathic diabetics. Podological evaluations were performed using a baropodometric platform, and later statistical analyses were made with the results obtained. Results - There is an association between age, gender, and increased BMI with the occurrence of neuropathy. More than half of the diabetic population in the study has associated peripheral neuropathy. The presence of deformities in the feet of the individuals in the sample was shown to have an influence on the occurrence of ulcer, as well as PPP and IPT values. It can be assumed that the value 88.06 kPa is a reference value for the development of an ulcer. Conclusions - There is a relationship between PP and the occurrence of ulcers. Podological analysis on a baropodometric platform allows us to understand whether or not the patient is at risk of developing an ulcer. This study shows a possible PPP value that serves as an indicator of the development of an ulcer on a diabetic foot. [ABSTRACT FROM AUTHOR]

Diabetes mellitus is a worldwide public health problem, it is estimated that the risk of microvascular complications in diabetics is about 10 to 20 times higher than in subjects without diabetes and the relative risk of macrovascular complications is greater than 2 to 4 times than individuals without the disease. Foot infection is related to the duration of the disease and the management of diabetic ulcers requires an understanding of the pathophysiology, together with a multimodal approach to infection control and care. With this it is important to define the treatment in the most appropriate nowadays. [ABSTRACT FROM AUTHOR]

Cornea is one of the most highly innervated tissues in the organism. Opioid receptors have already been detected in cornea; so the topical use of opioids is presented as an analgesic alternative in treatment of ulcerated corneas, with no damage in cicatrization. This research aimed to evaluate the corneal sensitivity of the 1% morphine sulfate solution in the intact cornea of dogs. Ten dogs with no ocular lesions were treated with one drop of saline solution on right eye (GC), and one drop of 1% morphine sulfate solution with the pH corrected for 7.2 on left eye (GM). The parameters evaluated were: tonometry, esthesiometry, Schirmer lacrimation test, pupil diameter and the presence of conjunctival hyperemia and blepharospasm with and without light source. The evaluations happened before collyrium instillation and 10, 20, 30, 60 and 240 minutes after it. It was performed variance analysis (ANOVA) for the parametric tests, comparing the means by the Tukey-Kramer test. Hyperemia and blepharospasm were evaluated by the chi-square test. The conjunctival hyperemia observed in the GM group was significantly higher (7/10) than in the CG group, which did not present hyperemia (P<0.05). Two eyes from GM showed blepharospasm with light source at 10 minutes. There were no differences in corneal sensibility, pupil diameter and Schirmer lacrimation test. The intraocular pressure was lower in the GM group compared to the GC group at 240 minutes. Topical administration of 1% morphine sulfate solution does not cause analgesia in intact cornea and promote irritation in eye and annex after instillation. [ABSTRACT FROM AUTHOR]

Background: Facial pressure ulcers are one of the most common complications associated with non-invasive ventilation (NIV ). Objectives: To determine the frequency of facial pressure ulcers in patients admitted to an intermediate care unit (ICU) and submitted to NIV, as well as to identify the associated factors. Methodology: A prospective study was conducted between September and December 2015. Inclusion criteria: age ≥ 18 years, admitted to ICU, submitted to NIV and without facial ulcers at time of admission. A sample of 30 participants was obtained. Data were collected through a questionnaire, the Braden Scale and the Glasgow Scale. Results: The frequency of facial pressure ulcers was 26.7%, 16.7% of stage II and with a mean onset of 3.3 days. Most participants were male (70.0%), and the mean age was 74.2 years. Patients undergoing more hours of VNI per day, more days of NIV and more days of hospitalization had a higher frequency of facial pressure ulcers. Conclusion: Given that the number of hours of NIV increased the frequency of Facial pressure ulcers, we suggest periods of interruption of NIV use. [ABSTRACT FROM AUTHOR]

The cytomegalovirus infection is prevalent in developed countries. The natural history of disease includes three phases: primoinfection (majority is asymptomatic), latency and reactivation. In certain immunosuppressive states, as in the case of transplantation and HIV infection, the virus can reactivate, occurring cutaneous manifestations, of what stands out the occurrence of genital ulcers. In these, co-infection with other etiologic agents is common, particularly with the herpes simplex virus, leading to more severe manifestations and difficulty in the differential diagnosis. In this context, it is relevant to know the pathogenesis of this virus and the diagnostics means available in order to optimize its therapy. [ABSTRACT FROM AUTHOR]

The herpes simplex virus is a common cause of genital ulcers. In the immunocompromised, it may have an atypical presentation, with exuberant lesions, frequently resulting in resistance to the mainstream therapeutic options, and a consequent prolonged course. A 25-year-old male with a previous history of common variable immunodeficiency, presented with herpetic extensive genital ulcerations on the inguinoscrotal region. Despite a long period of valacyclovir therapy, the patient remained symptomatic. We decided to add topical 5% imiquimod as an adjunctive therapy, and observed a completed resolution of the ulcerations. Imiquimod, working as a local immunomodulator, stimulates the anti-viral immunologic response. Therefore, it is an alternative in recalcitrant herpetic lesions, especially in the setting of immunosuppression. [ABSTRACT FROM AUTHOR]

The aim of this study was to evaluate the frequency of lesions in different regions of stomach of asymptomatic horses. Stomachs were evaluated macroscopically, which identified the nature of lesions. Subsequently, fragments were obtained from five regions previously mapped for histological examination, as well as from other areas with lesions. From a total of 21 animals, only one had isolated macroscopic lesion in glandular region, six in nonglandular region and 13 showed lesions in both regions. One animal showed no macroscopic lesion. Histologically, the most frequent lesions were gastritis (19/21), ulcers (14/21) and erosion (8/21). Most cases were acute ulcer and erosion, and gastritis chronic. The results of this study show the high frequency of lesions in the stomach of apparently healthy slaughter horses. [ABSTRACT FROM AUTHOR]