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Terbinafine hydrochloride (a white to off-white fine crystalline powder) is more than 20 years world-wide used synthetic allylamine derivative. Terbinafine is shown to be an effective antimycotic drug with a good safety profile. The mechanism of terbinafine antifungal activity is unidirectional in principle. Terbinafine hydrochloride is hypothesized to act by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. After local application, terbinafine penetrates and accumulates in epidermis. It starts to act quickly and seems to be effective after few days of treatment. Pharmacokinetics studies in humans revealed that absorption after local application trough skin is about 5%. The absorbed dose undergo extensive liver metabolism and than is almost completely excreted by urinary system (80%). [ABSTRACT FROM AUTHOR]

Terbinafine hydrochloride is more than 20 years world-wide used substance. Terbinafine is shown to be an effective antimycotic drug with a good safety profile. Its antifungal activity encompasses dermatophytes, yeasts, moulds and dimorphic fungi. Moreover, drug exhibits antibacterial and anti-inflammatory properties. The total cure ratio is assessed to be 78-100% for dermatophytes. A little bit worse effectiveness is observed for the treatment of pityriasis versicolor and yeast skin infections. Terbinefine therapy is very well tolerated, there is an absence of any serious adverse reactions (allergic or irritating). In clinical trials, minimal adverse reactions like transient itching, stinging/burning, irritation or redness were recorded (at the site of application) in 1.8% patients who received terbinafine cream. No case of overdosage has been reported with local used terbinafine cream. There is no evidence of mutagenicity or genotoxicity reported either (in vitro and in vivo). [ABSTRACT FROM AUTHOR]