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Background & Aims: Education is the main factor of economic growth in a country, and the curriculum is the heart of any education system. As civilization makes the transition from the industrial era to one of sustainability, educational leaders around the globe ought to implement a learning system that prepares young people for life in a unified society. Every country that has experienced high growth for a long time makes great efforts to educate its nation and reinforce its human capital. In contrast, there is considerable evidence that many developing countries are not doing enough. Education has a legal claim on public funds for at least two obvious reasons. First, the social returns are likely to be greater than the private returns. Second, some families with low incomes and credit constraints may not be able to invest as much in education as they would like, even if a higher income is guaranteed for a diploma or university degree in the case of a successful job search. Therefore, public spending on education is established based on impartial opportunity and efficiency. This paper provides a starting point to explore what skills and concepts students should be studying to lead the future. The curriculum model provides an explicit outline of some of the competencies that will likely be required for whatever world scenario emerges. This study focuses on the key roles of education and its relation to economic development as well as the curriculum as a core part of the entire educational drive of nations. In particular, the aim of the present study was to study the goals and contents of the high school curriculum of Group 7 countries and Iran with a focus on the differences and similarities of cognitive and metacognitive skills, which were compared with Iran in order to reach an appropriate model. Methods: The method used in this study is qualitative, seeking to understand a research phenomenon in its usual environment that leads to a deep understanding of the studied phenomenon. In particular, this research is a documentary analytical research with a comparative approach. The statistical population of the research in the first study, which had a comparative approach, includes all documents, printed and electronic texts regarding the curriculum elements of the selected countries. It includes all articles, websites, studies, and research related to the research topic. In the Delphi method, the presence of experts and experts in the subject is emphasized. Statistical sample: In this research, in the first part, after searching the official portals of the countries and databases, all the documents that contain the content of the curriculum elements of these countries have been found. Data analysis in qualitative research is the process of classifying, describing, and combining data. In this section, after collecting the information and data, the contents were separated into 4 components: goal, content, method, and evaluation for each country. Then it was analyzed based on John Stuart Mill's agreement and difference model. The analysis in the quantitative part includes Kendall's coefficient and confirmatory factor analysis with the help of SPSS22 and Amos Graphics version 23 software. Meanwhile, Maxqda18 software was used in the qualitative part and model extraction. All documents were translated by translators from IACTI (Iranian Certified Translators and Interpreters). It must be acknowledged that the process of translating the documents was complicated and difficult due to the different languages and finding the appropriate equivalent in Persian. 212 participants, including secondary school teachers, university professors, and Ph.D. students in the fields of curriculum and education management helped to confirm and categorize the collected information. In the next step, the Delphi method was used to obtain the opinions of experts and reach a consensus about the studied components. With a 5-point Likert style scale 80% agreement was obtained, which was regarded as attaining a minimum acceptable interrater agreement. Results: This study was motivated by doubts that have been raised about the role of education and human capital in economic development. These doubts come from a variety of vantage points ranging from whether the research has correctly identified the impact of education to whether other institutional aspects of countries might be more important. They also encompass concerns about whether or not we really know how to change educational outcomes, particularly in developing countries. The eight studied countries were divided into two groups for comparison: (a) Group of Seven, and (b) Iran. The objectives and content included in the curricula of these countries were identified, and then similarities and differences between these two groups were analyzed. The results show the importance of both minimal and high-level skills, the complementarity of skills and the quality of economic institutions, and the robustness of the relationship between skills and growth. International comparisons incorporating expanded data on cognitive skills reveal much larger skill deficits in developing countries than generally derived from just school enrollment and attainment. The magnitude of change needed makes clear that closing the economic gap with developed countries will require major structural changes in schooling institutions. Moreover, the results of this research showed that the goals and content of the curriculum of these countries often emphasize the areas of work and employment and are somehow economy-oriented. In Iran, there is not much emphasis on these areas in Iran. Although the principles and teachings of Islam pay attention to work, there is a lack of attention to this issue in the goals and content of the curriculum. It is suggested that there is an emergency need to review the national curriculum in Iran. Taking help from religious foundations in this field, such as paying attention to work and effort in Islam, avoiding laziness, and contentment, paying attention to halal earning and sustenance, etc., is very beneficial and enlightening. Using the fundamentals of Islam only in prohibitions and outward criticisms and only paying attention to prayer and fasting not only makes students evasive but also limits the main mission of religion which enlightens the path of people's lives and can open a way in their social and economic life. Pointing to the fact that the longest verse of the Holy Quran is in the field of economic transactions is one of the examples of the importance of the field of economics in Islam and proof of this matter. The lack of economic attention and cultivating students’ cognitive as well as metacognitive is felt in terms of preparing people for the future, after graduating from secondary education. It seems that it is better for the planners to update and modify the secondary school curriculum in line with economic development and changes in psychological knowledge. [ABSTRACT FROM AUTHOR]

Background & Aims: Neural activation is associated with increasing energy requirements, and increasing peripheral Lactate (LA) concentration in response to severe exercise, enhances LA supply as an energy substrate to meet acute neurological needs. The acute speed and football exercises may affect cognitive function by increasing LA concentration and nervous activation. Increasing the neurocognitive performance of growing adolescent boy players an important role in their physical performance. Therefore, the aim of the present study was to investigate the effect of speed and plyometric training activity on the concentrations of nerve proteins in blood circulation. Although speed interval and plyometric training in football players may lead to progressive fatigue and activate the central nervous system and subsequent cognitive disorders, it may also positively increase neurotrophines such as BDNF or IGF-1 and affect brain neutrophils and neurological function. According to this evidence, we assumed that BDNF, BNG and IGF-1 increase in response to a football training session, which may be associated with increasing neurological function of adolescents. Therefore, the purpose of the present study was to investigate the effect of an acute speed and plyometric football-based exercise on plasma concentrations of BDNF, BNG and IGF-1 neural proteins, which may play an important role in enhancing cognitive abilities. And the effect of speed and plyometric training activity on the concentrations of nerve proteins in blood circulation. Methods: The present study is a semi-experimental type with a pre-test and post-test design, which was conducted in two sessions, including an intervention and control session. After calling in Tehran's schools, 20 adolescents 14-15 years of age were selected and accessible as a sample, and randomly participated in 2 sessions of speed and plyometric exercises and control sessions. All subjects are familiar with how to perform speed exercises (RAST Test) during a familiarization period (two sessions). On the day of the main test, after 12 hours of fasting, the test was referred to the test site and the first blood sample (5 cc) was taken from the antiquiobital vein. After the standard breakfast of the subjects, we were wearing sportswear and after ten minutes of general warming up the speed training included six times a maximum of 35 meters with a 10-second recovery between each run. After the test was performed, the plyometric exercise was executed, including a pair jump and one -foot barriers, jump on barriers with 180 degrees rotation, zigzag jump and one foot forward, jump on obstacles with both legs and legs Single-tofoot jumping on the barriers of single -foot and throwing a medicine ball, on the sides, with 12 repetitions. The active rest between turn was considered two to three minutes (29). The subject's heart rate was performed during the controlled exercise (Polar heart rate monitor) and the exercise in the range of 80-90 % of the heart rate. The second blood sample was taken immediately after the training session was completed. All sampling steps for each subject were performed under the same conditions and the BDNF and NGF levels were measured through the USA-made Kit. The IGF-I levels were measured through the ELISA methods and IGF-I Kit. Cognitive neurological function was also measured through the Stroop test (ST) before and after the training session. In this study, the Polish paper version of ST was used. ST consisted of 71 words written with colored ink. The task of the participants was to name the font color regardless of the written word. For statistical analysis, the research data are first described using the mean and standard deviation, then the changes before and after all the variables of the two sessions were calculated and analyzed using the dependent stroop test. A significant level was considered to be P≤0.05 and SPSS 16 was used to perform statistical calculations. Results: The mean and standard deviation of the somatic specifications of the research subjects was as follow: Weight (59.7±3.2), Body mass index (21.4±1.3), Fat percentage (21.7±2.8), and Fat free mase (41.10±4.1) The results of the present study showed that BDNF data changes were significantly different in training and control session (t19=12/89, p<0/001). In the exercise session, the BDNF rate increased by approximately 2.5 times compared with control session. NGF data also showed significant differences in both sessions before and after acute speed and Plyometric training (t19=4.89, p<0/001). Regarding the plasma levels of IGF-1 also the results showed a quite significant difference in comparison of two sessions (t19 =2.89, p=0.019). The time of implementation of the stroop test at two sessions of training and control in the preceding and later times also showed significant differences that in the exercise session the test was significantly reduced than the control session (t19 =3.89, p=0/009). The test time in the exercise session decreased from 59.3s to 53.1s. There was no significant change in the control session at the time of stroop performance (58.6 s and 59.3 s). These findings show that acute speeds and plyometric exercise are useful for improving post exercise cognitive performance in adolescent. Skeletal muscle contraction during high-intensity exercise increases BDNF levels in the brain, and the speed and plyeometric exercise protocol is a more effective and preferred intervention to raise BDNF levels than traditional exercise mode, with moderate intensity. Acute speed and plyometric exercises increase human cognitive function. Improvement of cognitive function may be the synthesis or release of neurological proteins that are adjusted by high blood LA after exercise. Conclusion: In summary, the current findings suggest that acute plyometric and speed training enhances human cognitive performance. The improvement in cognitive performance may be from the synthesis or release of neuroprotective proteins modulated by high blood LA concentrations after exercise. [ABSTRACT FROM AUTHOR]

Background & Aims: Cancer is one of the most important issues in the world which affects public health as an important problem. Cancer is the third cause of death in Iran with an annual occurrence of 51,000 new cases [1]. Previous studies demonstrated the considerable increasing trends in the mortality of gastrointestinal cancer in Iran, especially for Gastric cancer and colorectal cancer [2]. In general, incidence rates of these two cancers are high in Eastern Europe, Eastern Asia, and South America and the lowest rates are in North America, and most parts of Africa [3]. The most critical factors that increases the risk of gastrointestinal cancer are aging, inappropriate diet, biological factors, and infectious diseases which contribute to the cancer occurrence [4]. Colon cancer is studied to be one of the most critical digestive diseases and is the second leading cause of cancer deaths [5]. Gastric cancer is important cancer in the world and the prevalence of gastric cancer is raised with aging in both men and women [6]. Colon cancer is a disorder in which malignant cells form in the large intestinal tissues [7]. On the other hand, in gastric cancer the malignant cells form in the lining layer of the stomach caused it. The risk of gastric cancer is high in Iran, and unlike in Western countries it is not under the control, thus it is on a dramatically increasing trend in Iran [8]. Secondary metabolites and phenolic compounds of plants can play an important role in reducing the side effects of chemotherapy drugs and have some positive effects on cancer cells, as well as in the expression of apoptotic pathway genes [9]. Colutea persica was used in traditional medicine as an anti-inflammatory agent in gastrointestinal problems [10]. The aim of this study was to investigate the cytotoxic effects of aqueous and hydroalcoholic extracts of Colutea persica on gastric cancer (AGS), colon cancer (HT-29), and normal fibroblast (SKM) cell lines. Methods: Fresh Colutea persica leaves were collected from the Delfard region of Kerman province in 1399. Dried leaves of Colutea persica were ground into a fine powder by the electronic grinder. At the next step, the ground powder was extracted using ethanol by the maceration. Then, it was placed on a shaker at room temperature. After that, the collective extracted was filtered using a filter membrane. The solvent extracted was evaporated in the rotary evaporator. Finally, to completely remove the solvent, the extract was placed in an oven, and the hydroalcoholic extract was maintained at -20 °C until use. In order to measure the total flavonoid content (TFC) of the extracts the aluminum chloride complex-forming assay was applied. In this method, quercetin was applied as the standard which flavonoid content was distinguished based on the quercetin equivalent. Briefly, Colutea persica extract was added to the aluminum chloride hexahydrate and mixed with potassium acetate and distilled water. After 30 minutes, the absorbance of the reaction was checked using a UV-Vis spectrophotometer at 415 nm. The blank sample was made by replacing aluminum chloride with deionized water. Before measuring, all of the solutions were filtered by using Whatmann filter papers (number 41). Total flavonoid content in Colutea persica extract was measured using the standard calibration curve which is achieved from different concentrations of the standard reference. The total phenolic content (TPC) of organic crude extracts was calculated using the FolinCiocalteu reagent method. In this method, gallic acid was used as a reference standard (20-100 μg/mL) for plotting the calibration curve. 0.5 mL of the Colutea persica extract was added to 1.5 mL of Folin-Ciocalteu solution. Then, it was diluted (1:10) with deionized water and added to the sodium carbonate solution. The absorbance was recorded after one hour at 765 nm by using a UV-Vis spectrophotometer. Finally, the total phenolic content was calculated based on gallic acid equivalents (mgGAE/g). All the experiments were done in triplicate. Cytotoxic effects of 5, 10, 25, 50, 100 μg/ml concentrations of aqueous and hydroalcoholic extracts were evaluated on the cells for 24 hours using MTT assay. The apoptosis induction was monitored using flowcytometry by annexin-V FITC/PI doublestaining. Cells were seeded and after 24 h they were incubated with a 1.25 mg/ml concentration of the extract and for each treated cell line, one control cell was considered. The annexin V/PI assay was performed to confirm the cytotoxic activity of the plant extracts against AGS and HT-29 cell lines. Total RNA was isolated from cells using RNX-plus TM Reagent before and after treatment. Total RNA was reverse transcribed to cDNA using M-MuLV-RT and random hexamers. The cDNA was assayed by real-time PCR using primers for BAX and BCL-2 genes. Data were analyzed using SPSS software, one way ANOVA, Tukey test at p ≤0.05... Results: The MTT assay revealed the cytotoxicity against both two cell lines (HT29 and AGS) in comparison to the HT29 and AGS normal cell line (SKM). The expression level of BAX gene increased and BCL2 gene decreased in AGS cell line after treatment by plant extract. (p<0.05). The total phenolic content was expressed in terms of milligram gallic acid equivalent per gram dry weight of plant extract. The total phenolic content of hydroalcoholic and aqueous extracts of Colutea persica were 5.02±.05 and 5.85.±0.08 mgGAE/g respectively. Conclusion: In conclusion, our findings show that Colutea. persica has anti-cancer effects in vitro against AGS and HT-29 cancer cell lines. Induction of apoptosis by using plant extract was achieved by down-regulation of BCL2 and up-regulation of BAX. Finally, the current study suggests that Colutea. persica may have cancer-fighting properties and could be a promising new candidate in this field. Besides, the molecular target of Colutea. persica and its mechanism are unknown, and the author intends to use animal models and bioinformatics methods to discover the active ingredients of Colutea. persica. [ABSTRACT FROM AUTHOR]

Background and Aim Training clinical students who learn the theoretical lessons in hospitals in practice will play an important role in improving treatment processes and providing better services to patients. Therefore, the purpose of this study is to identify the factors affecting the quality of clinical education in hospitals in Saveh City. Methods & Materials This research is a combination of exploratory studies and exploratory projects. In the qualitative stage, the qualitative method of Grand Strauss and Corbyn 1998 was used to explain the quality of clinical training. Since the students who have taken clinical courses in the Faculty of Medical Sciences of Saveh Hospitals in 1398-1397 are about 200 people and the professors and educators who teach these people are about 20 people, which according to Karajsi and Morgan, the sample size should be 140, of which 20 were interviewed and 120 were filled out with paper and electronic questionnaires. In this study, semi-structured interviews, and a researcher-made questionnaire with Cronbach’s alpha coefficient of 0.598 were selected as the data collection method. This research was performed using the qualitative method and using MAZQDA 10 and SPSS 26 software, the items obtained from qualitative research were collected and exploratory factor analysis was used to identify the factors. Ethical Considerations Considering that this study is one of the research priorities of Saveh School of Medical Sciences, it has a research license letter (No. 24.127. D.99). Results The results showed that the factors affecting the quality of clinical education include five factors. The first factor is space and facilities, the second factor is the improvement of educational processes, the third factor is educational and managerial deficiencies, the fourth factor is the evaluation of the teacher and the fifth factor is the qualitative improvement of education. Conclusion According to the quantitative and qualitative results of this study and by interviewing twenty experienced professors and student representatives, the factors affecting the quality of clinical education in Saveh hospitals were identified. [ABSTRACT FROM AUTHOR]

Introduction: 30 to 60% of patients admitted to non-psychiatric wards have at least one significant psychiatric illness. Objective: The aim of this study was to investigate the frequency, causes, and quality of psychiatric counseling requested. Materials and Methods: This descriptive study was carried out on all patients admitted to educational hospitals in Rasht, Iran from 2012 to 2014, for which psychiatric consultation was requested and their counseling sheets were available. Data were extracted based on the checklist. Assessment of the quality of the consultation request and the response quality of the counseling were done. Data were analyzed by SPSS21. Results: The frequency of psychiatric counseling application in this study was calculated to be 0/3%. A total of 905 counseling papers were reviewed. According to the data, 51/1% of patients were female and 48/9% were male, with the mean age of 45/7 years. For 54/7% of the patients, emergency counseling and for 45/3%, of them non-emergency counseling was requested. The most requesting counseling departments were surgery and internal medicine (14/6% and 12%, respectively). The lowest frequency of consultation requests was for anesthesiology department (0/1%). The most common reason for requesting psychiatric counseling was restlessness (26/75%) and then medication setting (14/45%). The most common diagnostic suspicion in response to counseling was delirium and the average duration for requesting counseling was 2.9 days after admission. Conclusion: Considering the relatively low frequency and quality of counseling in this study, more attention to the use of psychiatric counseling in medical patients and coherent training of assistants to improve the quality of counseling seem necessary. [ABSTRACT FROM AUTHOR]