1. De novo ペプチドナノポアの設計と精密 1 分子検出.
- Author
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清水啓佑, 宇佐美将誉, 溝口郁朗, 藤田祥子, and 川野竜司
- Subjects
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SYNTHETIC proteins , *BILAYER lipid membranes , *SINGLE molecules , *PEPTIDES , *MOLECULAR size - Abstract
De novo protein design has emerged as a method to manipulate the primary structure for the development of artificial proteins and peptides with desired functionality. This paper describes the de novo design of a pore-forming peptide that has a β-hairpin structure and assembles to form a stable nanopore in a bilayer lipid membrane. We designed two kinds of peptides, SV28: forming multidisperselysized nanopore and SVG28: monodispersely-sized nanopore, and succeeded to detect single molecule DNAs and polypeptides. Such de novo design of a β-hairpin peptide has the potential to create artificial nanopores, which can be adjust size to a target molecule. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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