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Résumé: Le dernier congrès de l'ISPOR Europe (International society for pharmacoeconomics and outcomes research) s'est tenu à Copenhague du 2 au 6 novembre 2019. Un groupe de pharmaciens, médecins et économistes en santé en synergie avec un groupe d'étudiants en master 2 de médico-économie présents à Copenhague, ont choisi de vous en restituer les messages forts. Cette synergie de groupe vise à développer « l'approche de la médico-économie sous toutes ses facettes ». Dans cet article, les auteurs évoquent les questions issues des différentes sessions et/ou posters, notamment l'évaluation des produits de santé : comment accélérer l'accès au marché des traitements tout en garantissant la pertinence clinique et la maîtrise des dépenses ? The last congress of ISPOR Europe (International society for pharmacoeconomics and outcomes research) was held in Copenhagen from 2 to 6 November 2019. A group of pharmacists, physicians and health economists in synergy with a group of students in Master 2 of medico-economics attending the conference have chosen to share some of the highlights. This group synergy aims to develop "the medico-economic approach in all its facets". In this paper, the authors discussed the following questions from the different sessions and/or posters, in particular the evaluation of health products: how to accelerate access to the treatment market while ensuring clinical relevance and control of spending? [ABSTRACT FROM AUTHOR]

Plurilingualism seems to have become a cause célèbre over the past decades in Europe. Nobody advocates monolingualism, even the British, who have practically eliminated languages from their curricula. This means that plurilingualism does not mean the same thing for everyone. In this paper, we are going to review a number of arguments put forward in favour of plurilingualism by the Council of Europe and various communities: the Anglophones, the speakers of less widely used and less taught (LWULT) languages, the specialists in intercomprehension, the militant plurilingualists, and finally, the French. We shall show that behind the rhetoric, each community is trying to press on with their own interests. European institutions have up to now failed to acknowledge the conflicting linguistic interests of their members and this probably explains why they have been unable to develop plurilingualism. This paper argues that any conflicting interests as there are should be carefully acknowledged so that Europeans can eventually design a language policy that will allow for the development of each language according to history and ambition. We shall give realistic guidelines for a global European language policy which can be adopted by each country and tailored to its own needs. We shall illustrate this with two examples: French, also valid for German and Italian, and Romanian, also valid for the less widely used languages. [ABSTRACT FROM AUTHOR]

Abstract: Grub/Kranawetberg, a multilayered Gravettian site in Lower Austria, is one of many Gravettian open-air sites of Central Europe. These sites are well-known since a long time for their settlement structures, but also rich lithic inventories as well as organic tools, personal adornments, and art objects (e.g., Pavlov, Dolní Vestonice). While old excavation and recording techniques do not allow a detailed intrasite spatial analysis of these sites, the ongoing fieldwork at Grub/Kranawetberg provides us with abundant and detailed information about spatial organization of a Gravettian open-air site in Central Europe. The site is excavated since 1993 and yielded four archaeological horizons with abundant finds (including numerous personal adornments) and some evident structures. The main focus of this paper is on the GIS-based methodology of intrasite spatial analysis, especially emphasizing the possibilities of recognizing formation processes, size-sorting and locating a possible dwelling. Application of various methods, among them piece-plotting, mapping of find quantities, application of kernel density estimates and ring and sector analysis, in the 1995 and 1996 excavation area showed latent structures which are interpreted as evidence for a dwelling in this area of the site. In the last part of the paper the evidence of Grub/Kranawetberg is discussed and compared with other European Gravettian sites. [Copyright &y& Elsevier]

Europe, an ambiguous word. Europe with its geographical meaning or the political Europe; the Europe of the European Council or the European Union? The truth is that present-days Europe has gone beyond its geographical meaning and left instead the political Europe. There is a union of values. This vision of Europe has been and still is the objective of the two major organizations: the Council of Europe, later on of the European Union, which has individually created its "own Europe" with several common elements. Why is the right to life at the centre of our study? This represents an important part of human rights and constitutes itself as a nucleus of these rights. They are called fundamental rights, are applicable to all people, under any circumstances and in any location: they cannot be subjected to any limitations or restrictions. Article 2, integrated among the most important articles of the European Convention consecrates one of the essential values of the democratic societies. This paper analyses the area of application of Article 2 of the European Convention and some aspects of the right to life and its application that have proved problematic, such as the abortion issue or the involuntary death. This paper is trying to clarify these dilemmas and to determine whether they fall under the application of Article 2 of the Convention. [ABSTRACT FROM AUTHOR]

This paper proposes the analysis of policies as the result of hegemonic phenomena. This perspective understands the diffusion of frames of reference as a phenomenon that is intrinsically conflictual. In so doing, our aim is to work around one of the main problems in the existing literature focused on the role of ideas and discourses: it tends to neglect the cognitive and symbolic struggles in which agents, who possess unequal resources, are engaged. We suggest analyzing the organization of a hegemonic phenomenon by focusing on the debates related to agri-environmental policies in England, France and Hungary. Generally, this article contributes an original outlook on the production of political order. [ABSTRACT FROM PUBLISHER]

The reference conditions are a key concept of the European Water Framework Directive (WFD). This directive holds that the ecological status of a particular water body shall be assessed by quantifying the deviation from the typical reference conditions which refer to a stable state of an ecosystem in the absence of significant human disturbance. This concept is subject to criticism from several authors, all the more since global change will deeply modify the functioning of aquatic ecosystems and their associated biocenosis, whatever the impacts of human activities at local scale. In this paper, an ecologist and a sociologist reconsider the social and scientific construction of the reference conditions concept and associated rules ("one out - all out"). We explain its origin, success and limits, as well as the questions it raises. We point out aspects not considered in this concept and why it challenges the WFD implementation and future management of rivers. [ABSTRACT FROM AUTHOR]

Since the adoption of the EU Water Framework Directive in 2000, all European waters are to achieve good ecological status by 2015. The strengthening of water policies involves an increased number of river basin management plans and even of river restoration projects at the local scale. In France the Environment Ministry is promoting a dam removal policy aimed at restoring the ecological continuity of rivers. This policy concerns medium dams and small weirs which were associated with mills. A part of these, however, continue to be used to produce electricity. Simultaneously, river and valley landscapes are drawing new attention involving multiple expectations linked to the valorization of river amenities, which can be at variance with the environmental issue. At local scale, observed conflicts illustrate local water governance difficulties. From the example of river restoration projects which we studied in northwestern France this paper attempts to throw light on different ways and goals of water management. If the regulated river is obsolete, how are rivers to evolve between ecological issues - "wild rivers" - and social objectives - "living rivers" -? [ABSTRACT FROM AUTHOR]

Evaluation of transgenic plants by ethics committees in Europe and Canada: what degrees of freedom? This paper examines from an ethical point of view the way some ethics committees in Europe and Canada evaluate transgenic plants. After analysing their reports and interviews with members sitting on these committees, we show the very relative independence of their evaluation from the scientists' position and political and industrial interests. We present here what an ethical evaluation of transgenic plants should be. Our study indicates that the more these committees develop an ethical reflection, the more they keep their distance from the social acceptability of genetically modified plants and the more they manage to avoid that scientific rationality replaces ethical argumentation - that is to say, the more they manage to incorporate scientific data in an ethical reflection. Some of these committees are even captive of a techno-scientific strategy which values research susceptible of making economic benefits, but prevents them from making an ethical evaluation. We show that making an independent ethical evaluation demands not to focus on the sole question of risks. All changes in the world associated with the development and marketing of transgenic plants should be examined. Ethical reflection also needs to be linked to an epistemological reflection in order to reinforce it. [ABSTRACT FROM AUTHOR]

Abstract: This paper''s main goal is to present the European Federation of Psychiatric Trainees. This organization, which gathers 28 European countries, continues to expand its borders and increase its skills. We will also talk about the latest news about EFPT through the presentation of its 19th annual Forum held in Prague in June 2011. [Copyright &y& Elsevier]

Abstract: In the current state of the debate about the Paleolithic in Europe the analysis of the transitional periods is one of the principal subjects. The accumulation of variable elements in time can determine a change in the technical systems from a more or less wide transitional phase. This paper will analyze the records of the North Plateau of the Iberian Peninsula for its chronology and/or for its technology as they are candidates for representing a transitional phase between the technological Modes 2 and 3 and will relate to the European context. This analysis will focus on support in the need to separate technological phenomena, transitions and the variability determined by the different spaces of occupation, the utilization of raw materials with unequal qualities and the functions of the site. [Copyright &y& Elsevier]

In this article the author considers the ruin as the focus of contradictory positions of rejection and even loathing in the process of ‘the transfer of the empire’ (translatio imperii) in historical time. The author considers questions of continuity and rupture, with relation to the idea of ruins and grand monuments on the one hand, and living empires and changing circumstances on the other. The author comments on the relations among material remains, mental images, linguistic artefacts and other types of objects in the progressive move away from antiquity and towards the empires of Christianity. The author shows that the city remains a fluid, but steady, presence amidst historical change. The paper argues for new constructions built on the infrastructure that is the ruins of the pagan past, and especially Rome. Ruins are an irresistible attraction but also instigating desperate attempts to sweep aside an ‘overflow of memory’. [ABSTRACT FROM PUBLISHER]

Abstract: In France, gamete donation is based on some fundamental principles such as anonymity, gratuity, and solidarity. In Europe a trend appeared for a removal of anonymity. This paper highlights the reasons for this removal of anonymity, and consequences for the donor''s offspring, the gamete donor, the infertile couples. In particular, an examination of practice shows that removing the anonymity of gamete donation favors maintaining the secrecy of the circumstances of the conception, resulting in inefficiency of the law. [Copyright &y& Elsevier]

Abstract: In this paper, we present the techno-typological study of level 16 of El Castillo cave (Archaic Aurignacian). In this level, we can identify an important bladelet production from schémas opératoires of unipolar prismatic cores, carinated endscraper and carinated burins types. Besides, we find a specific production of Discoid conception. The retouched blanks, though scanty, are dominated by the Dufour bladelets. Level 16 is in relation with the Archaic Aurignacian at the Cantabrian Iberia, which is present in sites like Cueva Morín, Labeko Koba, Gatzarria, or Isturitz and it also is in relation with the Mediterranean Archaic Aurignacian. Finally, we analyse the different hypotheses about the Initial Upper Paleolithic origin in Europe. The mosaic hypothesis is acceptable for us. [Copyright &y& Elsevier]

This paper deals with the making of the euro and the monetary frontiers of the euro zone, not overlapping with those of the European Union. At the very start of the monetary union, the dimension of the euro zone has been determined by the interplay of institutional and political pressures. After the last enlargement, only four small economies have managed to enter the euro. The present economic crisis has delayed the accession programmes of some new Member States. The central and eastern European countries are thus trying to ground their application on political criteria rather than on institutional ones. However the European Council has not given any positive answer to these claims. In the future the absorption of new members into the euro zone will be based on conditionality and adaptation of the structures of the monetary union, as it has to deal with a higher number of participants. [ABSTRACT FROM AUTHOR]

Abstract: Introduction: Physical activity is considered to be a tool for public health. Diseases resulting from a settled way of life should be prevented or solved by physical activity. This paper focuses on the role of national sport organisations in the socioeconomic context of health. Facts: An in-depth analysis of the relation between physical activity and health, of the pressure of the economical environment and of social stakeholders is done. An historical approach of sports organisations is presented. The various organisational and managerial challenges they have to face within different national sport systems in Europe are underlined. Conclusion: National sports organisations have to undergo a metamorphosis whether they want to become socioeconomic actors in the health sector. It is suggested that they should accept some social and behavioural missions included in the various national health plans. They should be granted in this context, in order to fulfil their mission of sport for all. [Copyright &y& Elsevier]

Abstract: The aim of this paper is to study the relation between climate change and the earliness of Birch pollination, a tree that produces allergenic pollen, which is of particular importance in north-western Europe. The study allowed us to make projections for the next few years in order to evaluate the evolution of Birch pollination starting date according to spring temperatures. It has been done in ten European locations, Kevo and Turku (Finland), London (United Kingdom), Paris and Lyon (France), Brussels (Belgium), Zürich (Switzerland), Vienna (Austria), Poznan and Cracow (Poland). The study period ranged from six to twenty-eight years depending on the city. Pollens were recorded daily thanks to volumetric Hirst traps, and the data were compared to monthly temperatures from January to May using correlations and multiple regressions. Except in Kevo where the trend is towards colder springs and a later pollination, in the other cities the results showed a spring warming associated with an earlier starting date of pollination: this trend is very well marked in Turku, Zürich, London, Vienna and Brussels, less evident in France while there is no trend in Poland. The results of this work should lead to an updating of the pollen calendars and the pollen forecast models, in the cities where there is a pronounced trend. [Copyright &y& Elsevier]

Abstract: This paper provides an overview of current knowledge of Plio Pleistocene Carnivora from Africa and Europe. In Plio Pleistocene times, many genera extend their ranges in Africa and Eurasia but their evolution are quite distinct in the two continents. In Africa, the modern carnivoran guild of sub saharian Africa originated in the early Pleistocene when took place extinction of archaic species. The north African fossil record is far from complete until the middle Pleistocene. In the middle and late Pleistocene, the modern carnivoran guild is associated with other elements: the simian jackal Canis simensis and two species of ursids Ursus arctos and Ursus deningeri which evolved towards Ursus spelaeus. Western European carnivore faunas show due to migration a constant turn-over of the species. Among felids, Panthera schaubi described by Viret (1954) and attributed to the genus Puma by Hemmer et al. (2004), is morphologically close to the snow leopard Panthera (Uncia) uncia. Canis etruscus is the sister group pf the clade including wolf and coyote and Canis arnensis is close to the African jackals. Ursus deningeri appears in the early Pleistocene together with two arctoid forms Ursus rodei and Ursus dolinensis that may be synonymous to Ursus arctos. The genus Hyaena is present in Europe in the middle and late Pleistocene. [Copyright &y& Elsevier]

Without radically upsetting the institutional and political balance of the Union, the Commission's White Paper on Governance, published 25 July 2001, proposes a new basis for the EU's institutional legitimacy. However, this conceptual re-foundation gives rise to new and fundamental questions. To speak of governance within democracy is indeed unthinkable unless 'governance' is redefined as a form of government where the legitimacy of public action (as well as its efficiency) is made possible by a 'proceduralisation' of law. The failure to promote legitimacy with concepts borrowed from the vocabulary of the nation-state is nevertheless puzzling: should the 'participatory democracy' be considered a substitute for representative democracy? Even if this is not the case, it is uncertain whether 'participatory democracy' sufficiently embodies the democratic ideal, at least at the European Union level. [ABSTRACT FROM AUTHOR]

Abstract--This paper presents some of the elements which have been typical of music in different contexts and cultures, and describes an approach to musical phenomena which relates them to the intercultural and interdisciplinary dimension of lifelong education (music considered as a cultural good, an expression form, a field of creativity, an artistic production and an aesthetic experience). From the educational point of view, the aim is to form ?multi-musical? individuals. In this framework are set the problem of musical identity and the need to spell out that identity in relation to stereotypes (popular music, classical music, folk music, etc.) and the differing shades of diversity. Particular attention needs to be given to the question of the universals seen in the psychology of music and the configuration of musical phenomena as structures which are organized hierarchically in several dimensions. In short, music in all its forms can help to form a dynamic, pluralist identity in the European context. [ABSTRACT FROM AUTHOR]