1. Systematic and practical solvent system selection strategy based on the nonrandom two-liquid segment activity coefficient model for real-life counter-current chromatography separation.
- Author
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Ren, Da-Bing, Yi, Lun-Zhao, Qin, Yan-Hua, Yun, Yong-Huan, Deng, Bai-Chuan, Lu, Hong-Mei, Chen, Xiao-Qing, and Liang, Yi-Zeng
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SOLVENTS , *CHROMATOGRAPHIC analysis , *SEPARATION (Technology) , *CHLOROFORM , *ALCOHOL-water mixtures - Abstract
Solvent system selection is the first step toward a successful counter-current chromatography (CCC) separation. This paper introduces a systematic and practical solvent system selection strategy based on the nonrandom two-liquid segment activity coefficient (NRTL-SAC) model, which is efficient in predicting the solute partition coefficient. Firstly, the application of the NRTL-SAC method was extended to the ethyl acetate/ n -butanol/water and chloroform/methanol/water solvent system families. Moreover, the versatility and predictive capability of the NRTL-SAC method were investigated. The results indicate that the solute molecular parameters identified from hexane/ethyl acetate/methanol/water solvent system family are capable of predicting a large number of partition coefficients in several other different solvent system families. The NRTL-SAC strategy was further validated by successfully separating five components from Salvia plebeian R.Br. We therefore propose that NRTL-SAC is a promising high throughput method for rapid solvent system selection and highly adaptable to screen suitable solvent system for real-life CCC separation. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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