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This paper presents a comparison of the two main regional damage estimation methodologies currently in use, namely the modified Mercalli intensity (MMI) based approach and the spectral parameter based approach. In the first methodology, expected damage is related to ground shaking intensity in terms of MMI through damage probability matrices. In the second methodology, the ground motion intensity is described in terms of spectral acceleration (SA), and building response in terms of spectral displacement (SD). Both methodologies were applied to buildings in Vancouver of three different construction types: single-family wood-frame houses, low-rise unreinforced masonry buildings, and high-rise concrete frame structures with concrete shear walls. The two methodologies predict damage that lies in the same general damage categories of light and moderate, which are defined by fairly broad ranges in mean damage factors. The specific mean damage factors predicted by the two methods for a given location are significantly different, however. The significant differences in mean damage factors imply significant differences in damage costs and hence in seismic risk. [ABSTRACT FROM AUTHOR]