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Summary: We developed a new tool to assess the severity of osteoporotic vertebral fracture using radiographs of the spine. Our technique can be used in patient care by helping to stratify patients with osteoporotic vertebral fractures into appropriate treatment pathways. It can also be used for research purposes. Purpose: The aim of our study was to propose a semi-quantitative (SQ) grading scheme for osteoporotic vertebral fracture (OVF) on anteroposterior (AP) radiographs. Methods: On AP radiographs, the vertebrae are divided into right and left halves, which are graded (A) vertical rectangle, (B) square, (C) traverse rectangle, and (D) trapezoid; whole vertebrae are graded (E) transverse band or (F) bow-tie. Type A and B were compared with normal and Genant SQ grade 1 OVF, Type C and D with grade 2 OVF, and Type E and F with grade 3 OVF. Spine AP radiographs and lateral radiographs of 50 females were assessed by AP radiographs SQ grading. After training, an experienced board-certified radiologist and a radiology trainee assessed the 50 AP radiographs. Results: The height-to-width ratio of the half vertebrae varied 1.32–1.48. On lateral radiographs, 84 vertebrae of the 50 patients had OVFs (38 grade 1, 24 grade 2, and 22 grade 3). On AP radiographs, the radiologist correctly assigned 84.2%, 91.7%, and 77.2% and the trainee correctly assigned 68.4%, 79.2%, and 81.8% of grade 1, 2, and 3 OVFs, respectively. Compared with lateral radiographs, the radiologist had a weighted Kappa of 0.944 including normal vertebrae and 0.883 not including normal vertebrae, while the corresponding Kappa values for the trainee were 0.891 and 0.830, respectively. Conclusion: We propose a new semi-quantitative grading system for vertebral fracture severity assessment on AP spine radiographs. [ABSTRACT FROM AUTHOR]

Summary: We propose a new class of priors for Bayesian hypothesis testing, which we name 'cake priors'. These priors circumvent the Jeffreys–Lindley paradox (also called Bartlett's paradox) a problem associated with the use of diffuse priors leading to nonsensical statistical inferences. Cake priors allow the use of diffuse priors (having one's cake) while achieving theoretically justified inferences (eating it too). We demonstrate this methodology for Bayesian hypotheses tests for various common scenarios. The resulting Bayesian test statistic takes the form of a penalised likelihood ratio test statistic. Under typical regularity conditions, we show that Bayesian hypothesis tests based on cake priors are Chernoff consistent, that is, achieve zero type I and II error probabilities asymptotically. We also discuss Lindley's paradox and argue that the paradox occurs with small and vanishing probability as sample size increases. [ABSTRACT FROM AUTHOR]

This article discusses a study that identified two novel mutations in the GREB1L gene in two Chinese families with renal agenesis (RA), a developmental disorder of the kidney. The mutations were associated with bilateral RA with deafness and unilateral RA with uterine abnormalities. The findings expand the understanding of the mutation spectrum of GREB1L and can improve prenatal counseling for future pregnancies. The study highlights the importance of retinoic acid signaling in kidney development and provides evidence of GREB1L mutations as a cause of renal abnormalities. [Extracted from the article]

Context. Coronal mass ejections (CMEs) are large-scale structures of magnetized plasma that erupt from the corona into interplanetary space. The launch of Solar Orbiter (SolO) in 2020 enables in situ measurements of CMEs in the innermost heliosphere, at such distances where CMEs can be observed remotely within the inner field of view of heliospheric imagers (HIs). It thus provides the opportunity for investigations into the correspondence of the CME substructures measured in situ and observed remotely. We studied a CME that started on 2022 March 10 and was measured in situ by SolO at ∼0.44 au. Aims. Combining remote observations of CMEs from wide-angle imagers and in situ measurements in the innermost heliosphere allows us to compare CME properties derived through both techniques, validate the estimates, and better understand CME evolution, specifically the size and radial expansion, within 0.5 au. Methods. We compared the evolution of different CME substructures observed in images from the HIs on board the Ahead Solar Terrestrial Relations Observatory (STEREO-A) and the CME signatures measured in situ by SolO. The CME is found to possess a density enhancement at its rear edge in both remote and in situ observations, which validates the use of the signature of density enhancement following the CMEs to accurately identify the CME rear edge. We also estimated and compared the radial size and radial expansion speed of different substructures in both observations. Results. The evolution of the CME front and rear edges in remote images is consistent with the in situ CME measurements. The radial expansion (i.e., radial size and radial expansion speed) of the whole CME structure consisting of the magnetic ejecta and the sheath is consistent with the in situ estimates obtained at the same time from SolO. However, we do not find such consistencies for the magnetic ejecta region inside the CME because it is difficult to identify the magnetic ejecta edges in the remote images. [ABSTRACT FROM AUTHOR]