1. TTYH3 Promotes Cervical Cancer Progression by Activating the Wnt/β-Catenin Signaling Pathway.
- Author
-
Huang, Xiuyan, Li, Qing, Zheng, Xiaoxia, and Jiang, Chen
- Subjects
- *
PROTEIN metabolism , *T-test (Statistics) , *POLYMERASE chain reaction , *CELL proliferation , *APOPTOSIS , *CELL physiology , *CELLULAR signal transduction , *DESCRIPTIVE statistics , *IN vivo studies , *GENE expression , *MICE , *CELL lines , *EXPERIMENTAL design , *IMMUNOHISTOCHEMISTRY , *GROWTH factors , *ANIMAL experimentation , *ANALYSIS of variance , *DISEASE progression ,CERVIX uteri tumors - Abstract
The role of tweety homolog 3 (TTYH3) has been studied in several cancers, including hepatocellular carcinoma, cholangiocarcinoma, and gastric cancer. The results showed that TTYH3 is highly expression in cervical cancer tissues and cells and high TTYH3 expression correlates with poor prognosis in patients with cervical cancer. TTYH3 markedly reduced the apoptosis rate and promoted proliferation, migration, and invasion. Silencing of TTYH3 has been shown to have an inhibitory effect on cervical cancer progression. Moreover, TTYH3 enhanced EMT and activated Wnt/β-catenin signaling. Furthermore, TTYH3 knockdown inhibited the tumor growth in vivo. In conclusion, TTYH3 promoted cervical cancer progression by activating the Wnt/β-catenin signaling. HIGHLIGHTS: TTYH3 is upregulated in cervical cancer tissue and cells. TTYH3 promotes cervical cancer cell proliferation. TTYH3 inhibits cervical cancer cell apoptosis. TTYH3 induces cervical cancer cell migration and invasion. TTYH3 activates the Wnt signaling in cervical cancer cell. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF