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Objectives: Endoscopic ultrasound‐guided tissue acquisition (EUS‐TA) is used for pathological diagnosis and obtaining samples for molecular testing, facilitating the initiation of targeted therapies in patients with pancreatic cancer. However, samples obtained via EUS‐TA are often insufficient, requiring more efforts to improve sampling adequacy for molecular testing. Therefore, this study investigated the use of oil blotting paper for formalin fixation of samples obtained via EUS‐TA. Methods: This prospective study enrolled 42 patients who underwent EUS‐TA for pancreatic cancer between September 2020 and February 2022 at the Osaka International Cancer Institute. After a portion of each sample obtained via EUS‐TA was separated for routine histological evaluation, the residual samples were divided into filter paper and oil blotting paper groups for analysis. Accordingly, filter paper and oil blotting paper were used for the formalin fixation process. The total tissue, nuclear, and cytoplasm areas of each sample were quantitatively evaluated using virtual slides, and the specimen volume and histological diagnosis of each sample were evaluated by an expert pathologist. Results: All cases were cytologically diagnosed as adenocarcinoma. The area ratios of the total tissue, nuclear, and cytoplasmic portions were significantly larger in the oil blotting paper group than in the filter paper group. The frequency of cases with large amount of tumor cells was significantly higher in the oil blotting paper group (33.3%) than in the filter paper group (11.9%) (p = 0.035). Conclusions: Oil blotting paper can increase the sample volume obtained via EUS‐TA on glass slides and improve sampling adequacy for molecular testing. [ABSTRACT FROM AUTHOR]

Adopting a scoping review method, we examined peer‐reviewed academic papers published about human–lion conflict (HLC) (including coexistence) and identified knowledge gaps. We searched papers published between January 1981 and December 2023 using academic databases, with the key terms African lion, human–lion conflict, human–lion coexistence, and human–lion interaction. This produced 485 records, reduced to 137 after using additional criteria. Ninety‐eight papers were focused on lions in Kenya, Tanzania, Zimbabwe, and Botswana. Ten pan‐African studies were identified in our review. Our inductive analysis identified four themes related to HLC: attitudes and perceptions toward lions, causes of HLC, consequences of HLC, and mitigating HLC. Some limitations identified in systematic reviews of human–wildlife conflict have been addressed in recent years, such as broadening the geographical scale of research. However, some knowledge gaps remain, including a lack of assessment of mitigation strategies and studies on climate changes impact on human–lion conflict. Addressing the knowledge gaps highlighted in this review will require diversifying the disciplinary composition of the research teams and increasing researcher reflexivity. [ABSTRACT FROM AUTHOR]

In this work, stacked SiC fibers paper‐reinforced SiC ceramic matrix composites (SiCnf/SiC CMCs) were prepared by nanoimpregnation and transient eutectic (NITE) process using ultra‐long single‐crystal SiC nanofibers. The effect of the SiCnf surface modification via boron nitride (BN) interphase deposition as well as the sintering additive (Al2O3–Y2O3) content on the density, microstructure, and mechanical properties of SiCnf/SiC CMCs has been investigated systematically. The results revealed that the laminated SiCnf/SiC CMCs feature a significant saw‐tooth‐like curve on the load–displacement test, which indicates that the obtained laminated structure with the weak interlayer binding owning to the BN coating treatment possesses significant toughening to the SiC ceramics. Specifically, the SiCnf/SiC CMCs with the sintering additive content of 12 wt% revealed a fracture toughness of over 10 MPa m1/2 after 60 min of BN interface deposition, which is 104.31% higher than that of the composites prepared without BN coating. [ABSTRACT FROM AUTHOR]

Aims: Information on breastfeeding and safety of biologics in infants is lacking due to difficulties in case collection. We evaluated methods for determining the concentration of biologics in breast milk using a dry filter method that can simplify the collection, storage and transport of breast milk. Methods: To generate dried filter paper (DFP) samples, approximately 30 μL of breast milk was placed onto a Whatman 903 card and punched out. After extraction, the supernatant was measured using an enzyme‐linked immunosorbent assay. Three concentrations of each drug were prepared in liquid breast milk (LBM) and DFP samples to determine their stability up to 28 days after storage at 2–8°C or −20°C for LBM and 25 ± 5°C for DFP. LBM and DFP samples were also provided by nursing mothers using biologics during lactation, and drug concentrations in both samples were compared. The agreement between the two measurement methods was confirmed by Bland–Altman analysis. Results: Breast milk was provided by 12 mothers who used biologics (tocilizumab, abatacept, etanercept, golimumab, sarilumab and belimumab). The coefficients of variation for within‐run and between‐run precision for the six drugs were within 15% for both LBM and DFP, and accuracy was within 90%–110% of the quality controls. After 28 days, concentrations remained at more than 90%. The difference between the values obtained by each method was within the acceptable range of error (−12.1 to +16.6 ng/mL). Conclusions: A method for determining the concentration of biologics using DFP is expected to help improve pharmacotherapy for lactating women. [ABSTRACT FROM AUTHOR]

Laser‐induced graphene (LIG) technology has provided a new manufacturing strategy for the rapid and scalable assembling of triboelectric nanogenerators (TENG). However, current LIG‐based TENG commonly rely on polymer films, e.g., polyimide (PI) as both friction material and carbon precursor of electrodes, which limit the structural diversity and performance escalation due to its incapability of folding and creasing. Using specialized PI paper composed of randomly distributed PI fibers to substantially enhance its foldability, this work creates a new type of TENG, which are structurally foldable and stackable, and performance tailorable. First, by systematically investigating the laser power‐regulated performance of single‐unit TENG, the open‐circuit voltage can be effectively improved. By further exploiting the folding process, multiple TENG units can be assembled together to form multi‐layered structures to continuously expand the open‐circuit voltage from 5.3 to 34.4 V cm−2, as the increase of friction units from 1 to 16. Last, by fully utilizing the unique structure and performance, representative energy‐harvesting and smart‐sensing applications are demonstrated, including a smart shoe to recognize running motions and power LEDs, a smart leaf to power a thermometer by wind, a matrix sensor to recognize writing trajectories, as well as a smart glove to recognize different objects. [ABSTRACT FROM AUTHOR]

This study attempts to detect papers originating from the Russia‐based paper mill 'International Publisher' LLC. A total of 1,063 offers to purchase co‐authorship on a fraudulent papers published from 2019 to mid‐2022 on the 123mi.ru website were analysed. This study identifies at least 451 papers that are potentially linked to the paper mill, including one preprint, a duplication paper and 16 republications of papers erroneously published in hijacked journals. Evidence of suspicious provenance from the paper mill is provided: matches in title, number of co‐authorship slots, year of publication, country of the journal, country of a co‐authors and similarities of abstracts. These problematic papers are co‐authored by scholars from at least 39 countries and are submitted to both predatory and reputable journals. This study also demonstrates collaboration anomalies in questionable papers and examines indicators of the Russia‐based paper mill. The value of co‐authorship slots offered by 'International Publisher' LLC from 2019 to 2021 is estimated at $6.5 million. Since this study only analysed a single paper mill, it is likely that the number of papers with forged authorship is much higher. [ABSTRACT FROM AUTHOR]

To compare the urine Congo‐red dot paper test (CRD) with dipstick urinalysis to screen preeclampsia (PE). A total of 409 paired spot urine samples were obtained prospectively from women with suspected pre‐eclampsia attending for routine hospital visits. Congo‐red dot paper test and dipstick urinalysis were examined and compared to screen pre‐eclampsia. The agreement between the two urinary test is modest (kappa coefficient = 0.28, 95% CI 0.14–0.42). The specificity of CRD was higher than urinalysis (97.4% vs. 90.4%, p <.001). Urinalysis performed better in sensitivity (77.3% vs. 40.9%, p =.04) and the area under the receiver operating characteristic curves (AUC) (0.84 [95% CI 0.74–0.94] vs. 0.69 [95% CI 0.55–0.83], p =.04) than CRD, respectively. The sensitivity, specificity, AUC of the parallel test of them is 86.4% (64.0%–96.4%), 89.1% (85.5%–92.0%), and 0.88 (95% CI 0.79–0.96). And the serial test is 31.8% (14.7%–54.9%), 98.7% (96.8%–99.5%), 0.65 (95% CI 0.51–0.79), accordingly. The urinalysis is a better diagnosing test for preeclampsia. CRD could aid in the diagnosis of patients with preeclampsia. Combined the two tests in suspected patients may further improve the performance in the diagnosis of preeclampsia. Further study need to be made for its potential clinical practice. [ABSTRACT FROM AUTHOR]

Power outages can cause harm to both society and individual health. Among the crucial elements of power systems, power transformers play a vital role, and their failures can lead to incidents and disruptions. According to statistics, almost 50% of the explosions and fires in the power transformer are caused by oil‐impregnated paper (OIP) bushing failures. Moreover, moisture is a crucial factor that affects the health of OIP bushings, and assessing the moisture level in OIP bushings is vital to guarantee the safety of power systems. While the frequency‐domain dielectric spectroscopy (FDS) method has been widely used to assess the moisture content of OIP bushings on‐site, it has the disadvantage of requiring a long measurement time. Therefore, a novel technique was proposed in this study that involves measuring the OIP bushing dissipation factor (tanδ) at 1 Hz to estimate the moisture content in a significantly shorter time. Five samples of OIP with various moisture levels have been selected, and an equation based on the OIPs' value of tanδ at 1 Hz was proposed to assess the moisture level of OIP bushings. Furthermore, the validity of the proposed method was successfully verified, proving its precision and time efficiency. [ABSTRACT FROM AUTHOR]

This paper analyses the conference papers published by double first‐class universities from mainland China between 2006 and 2019. The main findings are as follows: first, the number of conference papers from different double first‐class universities varied greatly, with the annual numbers of papers in the China Proceedings of Conferences Full‐text Database (CPCD) and in the Conference Proceedings Citation Index (CPCI) fluctuating during this period. Second, most of the top 10 disciplines of the papers in the CPCD and CPCI were in the natural sciences, with only two in the social sciences. The CPCD papers and CPCI papers had some overlap in their disciplinary distributions. Third, the CPCD and CPCI papers differed little in total number, with the number of CPCI papers being slightly higher than the number of CPCD papers. With the introduction of new regulations from the Ministry of Science and Technology (MST), there will likely be an increase in the number of Chinese‐language conference papers in the future. [ABSTRACT FROM AUTHOR]

The erratic, intermittent, and unpredictable nature of sweat production, resulting from physiological or psychological fluctuations, poses intricacies to consistently and accurately sample and evaluate sweat biomarkers. Skin‐interfaced microfluidic devices that rely on colorimetric mechanisms for semi‐quantitative detection are particularly susceptible to these inaccuracies due to variations in sweat secretion rate or instantaneous volume. This work introduces a skin‐interfaced colorimetric bifluidic sweat device with two synchronous channels to quantify sweat rate and biomarkers in real‐time, even during uncertain sweat activities. In the proposed bifluidic‐distance metric approach, with one channel to measure sweat rate and quantify collected sweat volume, the other channel can provide an accurate analysis of the biomarkers based on the collected sweat volume. The closed channel design also reduces evaporation and resists contamination from the external environment. The feasibility of the device is highlighted in a proof‐of‐the‐concept demonstration to analyze sweat chloride for evaluating hydration status and sweat glucose for assessing glucose levels. The low‐cost yet highly accurate device provides opportunities for clinical sweat analysis and disease screening in remote and low‐resource settings. The developed device platform can be facilely adapted for the other biomarkers when corresponding colorimetric reagents are exploited. [ABSTRACT FROM AUTHOR]

Introduction: Poor communication is a leading root cause of preventable maternal mortality in the United States. Communication challenges are compounded with the presence of biases, including racism. Hospital administrators and clinicians are often aware that communication is a problem, but understanding where to intervene can be difficult to determine. While clinical leadership routinely reviews incident reports and acts on them to improve care, we hypothesized that reviewing incident reports in a systematic way might reveal thematic patterns, providing targeted opportunities to improve communication in direct interaction with patients and within the healthcare team itself. Methods: We abstracted incident reports from the Women's Health service and linked them with patient charts to join patient's race/ethnicity, birth outcome, and presence of maternal morbidity and mortality to the incident report. We conducted a qualitative content analysis of incident reports using an inductive and deductive approach to categorizing communication challenges. We then described the intersection of different types of communication challenges with patient race/ethnicity and morbidity outcomes. Results: The use of incident reports to conduct research on communication was new for the health system. Conversations with health system‐level stakeholders were important to determine the best way to manage data. We developed a thematic codebook based on prior research in healthcare communication. We found that we needed to add codes that were equity focused, as this was missing from the existing codebook. We also found that clinical and contextual expertise was necessary for conducting the analysis—requiring more resources to conduct coding than initially estimated. We shared our findings back with leadership iteratively during the work. Conclusions: Incident reports represent a promising source of health system data for rapid improvement to transform organizational practice around communication. There are barriers to conducting this work in a rapid manner, however, that require further iteration and innovation. [ABSTRACT FROM AUTHOR]

Personalized healthcare management is an emerging field that requires the development of environment‐friendly, integrated, and electrochemical multimodal devices. In this study, the concept of integrated paper‐based biosensors (IFP−Multi) for personalized healthcare management is introduced. By leveraging ink printing technology and a ChatGPT–bioelectronic interface, these biosensors offer ultrahigh areal‐specific capacitance (74633 mF cm−2), excellent mechanical properties, and multifunctional sensing and humidity power generation capabilities. More importantly, the IFP−Multi devices have the potential to simulate deaf‐mute vocalization and can be integrated into wearable sensors to detect muscle contractions and bending motions. Moreover, they also enable monitoring of physiological signals from various body parts, such as the throat, nape, elbow, wrist, and knee, and successfully record sharp and repeatable signals generated by muscle contractions. In addition, the IFP−Multi devices demonstrate self‐powered handwriting sensing and moisture power generation for sweat‐sensing applications. As a proof‐of‐concept, a GPT 3.5 model‐based fine‐tuning and prediction pipeline that utilizes recorded physiological signals through IFP−Multi is showcased, enabling artificial intelligence with multimodal sensing capabilities for personalized healthcare management. This work presents a promising and ecofriendly approach to developing paper‐based electrochemical multimodal devices, paving the way for a new era of healthcare advancements. [ABSTRACT FROM AUTHOR]

Key points: Academia is already witnessing the abuse of authorship in papers with text generated by large language models (LLMs) such as ChatGPT.LLM‐generated text is testing the limits of publishing ethics as we traditionally know it.We alert the community to imminent risks of LLM technologies, like ChatGPT, for amplifying the predatory publishing 'industry'.The abuse of ChatGPT for the paper mill industry cannot be over‐emphasized.Detection of LLM‐generated text is the responsibility of editors and journals/publishers. [ABSTRACT FROM AUTHOR]

Avoiding financial losses requires preventing catastrophic oil‐filled power transformer breakdowns. Continuous online transformer monitoring is needed. The authors use paper insulation to evaluate transformer health for continuous online transformer monitoring. The study suggests a new artificial intelligence method for estimating paper insulation residual life in oil‐immersed power transformers. The four artificial intelligence models use backpropagation‐based neural networks to predict paper insulation lifespan. Four primary transformer insulating paper failure indices—degree of polymerisation, 2‐furfuraldehyde, carbon monoxide, and carbon dioxide—form the basis of these models. Each model, including the backpropagation‐based neural networks, estimates paper insulation life using one failure index, along with moisture and temperature data. Optimisation techniques enhance hidden layer neurons and epoch count for improved performance. Results are validated against literature‐based life models, establishing a precise input–output correlation. This method accurately predicts the remaining useable life of power transformer paper insulation, enabling utilities to take proactive measures for safe and efficient transformer operation. [ABSTRACT FROM AUTHOR]

A variety of terms, such as "antiepileptic," "anticonvulsant," and "antiseizure" have been historically applied to medications for the treatment of seizure disorders. Terminology is important because using terms that do not accurately reflect the action of specific treatments may result in a misunderstanding of their effects and inappropriate use. The present International League Against Epilepsy (ILAE) position paper used a Delphi approach to develop recommendations on English‐language terminology applicable to pharmacological agents currently approved for treating seizure disorders. There was consensus that these medications should be collectively named "antiseizure medications". This term accurately reflects their primarily symptomatic effect against seizures and reduces the possibility of health care practitioners, patients, or caregivers having undue expectations or an incorrect understanding of the real action of these medications. The term "antiseizure" to describe these agents does not exclude the possibility of beneficial effects on the course of the disease and comorbidities that result from the downstream effects of seizures, whenever these beneficial effects can be explained solely by the suppression of seizure activity. It is acknowledged that other treatments, mostly under development, can exert direct favorable actions on the underlying disease or its progression, by having "antiepileptogenic" or "disease‐modifying" effects. A more‐refined terminology to describe precisely these actions needs to be developed. [ABSTRACT FROM AUTHOR]

Decision prediction based on neurophysiological signals is of great application value in many real‐life situations, especially in human–AI collaboration or counteraction. Single‐trial analysis of electroencephalogram (EEG) signals is a very valuable step in the development of an online decision‐prediction system. However, previous EEG‐based decision‐prediction methods focused mainly on averaged EEG signals of all decision‐making trials to predict an individual's general decision tendency (e.g., risk seeking or aversion) over a period rather than on a specific decision response in a single trial. In the present study, we used a rock–paper–scissors game, which is a common multichoice decision‐making task, to explore how to predict participants' single‐trial choice with EEG signals. Forty participants, comprising 20 females and 20 males, played the game with a computer player for 330 trials. Considering that the decision‐making process of this game involves multiple brain regions and neural networks, we proposed a new algorithm named common spatial pattern‐attractor metagene (CSP‐AM) to extract CSP features from different frequency bands of EEG signals that occurred during decision making. The results showed that a multilayer perceptron classifier achieved an accuracy significantly exceeding the chance level among 88.57% (31 of 35) of participants, verifying the classification ability of CSP features in multichoice decision‐making prediction. We believe that the CSP‐AM algorithm could be used in the development of proactive AI systems. [ABSTRACT FROM AUTHOR]

The research presented in this paper introduces a novel environmental energy‐harvesting technology that harnesses electricity from the evaporation of water using porous structural materials. Specifically, a strategy employing paper‐based hydroelectric generators (p‐HEGs) is proposed to capture the energy produced during water evaporation and convert it into usable electricity. The p‐HEGs offer several advantages, including simplicity in fabrication, low cost, and reusability. To evaluate their effectiveness, the water evaporation‐induced electrical output performance of four different p‐HEGs are compared. Among the variants tested, the p‐HEG combining wood pulp and polyester fiber exhibits the best output performance. At room temperature, this particular p‐HEG generates a short‐circuit current and open‐circuit voltage of ≈0.4 µA and 0.3 V, respectively, thereby demonstrating excellent electrical stability. Furthermore, the electrical current and voltage generated by the p‐HEG through water evaporation are able to power an LED light, both individually and in series and parallel connections. This study delves into the potential of electricity harvesting from water evaporation and establishes it as a viable method for renewable energy applications. [ABSTRACT FROM AUTHOR]

Work in teacher noticing has captured to what extent teachers notice students' thinking on paper and pencil tasks and technology tasks, yet no one study has considered how the same group of teachers notices across task types. This study used Jacobs et al.'s (Journal for Research in Mathematics Education, 2010, 41(2), pp: 169–202.) professional noticing of students' thinking framework to guide the design and analysis of prospective secondary mathematics teachers' (PSMTs) noticing of high school students' thinking on two geometry tasks: a paper and pencil task and a technology task. High school students' written work and a video clip were shared as the artifacts from which to notice for each task. PSMTs responded to a set of noticing prompts to capture how they were attending, interpreting, and deciding to respond to students' thinking for each task. Their written responses to these questions were then open coded for each noticing component and codes from each task were compared to reveal any differences in the content of PSMTs' noticing across task types. Results revealed differences between tasks for each component skill of noticing. Implications of these findings for mathematics teacher educators and future research are discussed. [ABSTRACT FROM AUTHOR]

Polistes dominula is an invasive social wasp that preys on the grasshopper Dichroplus elongatus, which constitutes a potential agricultural pest in Northwest Patagonia. This grasshopper feeds on a wide variety of plants, the 'Dandelion' (Taraxacum officinale) being one of the main food resources. In this study, by means of a Y‐tube olfactometer, we analysed the use of olfactory cues by P. dominula in the detection of grasshoppers. Specifically, we evaluated the attractiveness of live grasshoppers, their traces (i.e. leaves with herbivory traces + prey faeces or only faeces) and herbivory‐free leaves. The results showed that foragers equally chose olfactory cues emitted by grasshoppers and leaves with herbivory traces + faeces and herbivory‐free leaves, suggesting that the leaves of the host plant also have an important role in the searching behaviour. The current research is the first to demonstrate that the invasive paper wasp orients its search towards either the presence of grasshopper prey or the volatiles of plant leaves. These findings shed new light on predator‐prey interactions mediated by olfactory cues in P. dominula, which may play a biological role as a natural controller of D. elongatus, phytophagous pest in the invaded ecosystems. [ABSTRACT FROM AUTHOR]

Retracted articles by Indian scholars have received significant attention in recent times. However, no comprehensive study has been conducted to analyse the citations of retracted papers authored by Indian researchers. This study aimed to assess the citations to retracted works published between 2001 and 2020 pre‐ and post‐retraction. The study found that there was an increase in retractions over time, with empirical data suggesting that the number of retractions has increased significantly, from 72 papers between 2001 and 2010 to 365 papers between 2011 and 2020. Duplication (n = 128) and plagiarism (n = 119) were the primary reasons for retraction. Notably, 90% of the retracted articles continued to receive citations after retraction. Among the retracted papers, eight received more than 50 post‐retraction citations, 39 received 20 to 50 citations, 347 received one to 19 citations, and 43 were not cited at all post‐retraction. There was an overall 8% decrease in citations after retraction. Retractions were observed across journals of varying impact factor, with a higher number of retractions observed in journals with an impact factor of less than 5 (n = 286; 65%). Furthermore, smaller research teams of two to five authors accounted for 72% of the total retractions. [ABSTRACT FROM AUTHOR]

How might the visibility of an author's name and/or institutional affiliation allow bias to enter the evaluation of economics papers? We ask highly qualified journal editors to review abstracts of solo‐authored papers which differ along the dimensions of gender and institution of the author. We exogenously vary whether editors observe the name and/or institution of the author. We identify positive name visibility effects for female economists and positive institution visibility effects for economists at the top institutions. Our results suggest that male economists at top institutions benefit the most from non‐blind evaluations, followed by female economists (regardless of their institution). [ABSTRACT FROM AUTHOR]

Vigilant animals detect and respond to threats in the environment, often changing posture and movement patterns. Vigilance is modulated not only by predators but also by conspecific threats. In social animals, precisely how conspecific threats alter vigilance behavior over time is relevant to long‐standing hypotheses about social plasticity. We report persistent effects of a simulated conspecific challenge on behavior of wild northern paper wasp foundresses, Polistes fuscatus. During the founding phase of the colony cycle, conspecific wasps can usurp nests from the resident foundress, representing a severe threat. We used automated tracking to monitor the movement and posture of P. fuscatus foundresses in response to simulated intrusions. Wasps displayed increased movement, greater bilateral wing extension, and reduced antennal separation after the threat was removed. These changes were not observed after presentation with a wooden dowel. By rapidly adjusting individual behavior after fending off an intruder, paper wasp foundresses might invest in surveillance of potential threats, even when such threats are no longer immediately present. The prolonged vigilance‐like behavioral state observed here is relevant to plasticity of social recognition processes in paper wasps. [ABSTRACT FROM AUTHOR]

Epoxy‐impregnated paper transformer bushings are prone to water absorption due to the presence of water‐attracting moieties in the cellulose chemical structure and epoxy resin, leading to moisture‐induced insulation defects. To understand the mechanism of moisture's impact on epoxy‐impregnated paper, this study developed a testing platform that integrated moisture diffusion, adsorption, and dielectric properties of insulating materials. Insulation specimens made of epoxy resin and epoxy‐impregnated paper were prepared and their water diffusion characteristics were investigated using the Fick diffusion model and the Langmuir model, respectively. The Guggenheim–Anderson–de Boer equation was used to examine the vacuum vapour adsorption characteristics of the materials, providing a theoretical foundation for examining the form of water present within them. The dielectric response of materials with varying moisture levels was then tested to study the effect of water on the dielectric spectrum curve. Using the Extended Derivative Method, the characteristic frequency reflecting the water content of the epoxy‐impregnated paper was extracted. The results demonstrate that 0.01‐Hz characteristic frequency provides superior accuracy for moisture assessment in epoxy resins compared to 50 Hz, and extracting and fitting the relaxation peak characteristic frequency in epoxy‐impregnated paper moisture evaluation yields higher accuracy than using tan δ at the power frequency. [ABSTRACT FROM AUTHOR]

Aiming at developing an easily implementable method for on‐site analysis to detect urea adulteration in feed ingredients, a simple and inexpensive paper strip for urea detection via colorimetric assay is herein presented. The paper strip can be simply fabricated by immobilizing urease with bromothymol blue (BTB) as a pH indicator on cellulose fiber. Upon dipping the paper strip into the target sample, the release of ammonia during the reaction between urea in the sample and urease on the paper strip causes a pH change that results in the development of a blue color, thus indicating the presence of urea. A semiquantitative detection method was developed on the basis of the color change on the paper strip, which can be detected by naked eyes and compared with a color chart made by spiking urea at concentrations varying from 0.10% to 1.0% (w/w) in animal protein and fishmeal samples. Moreover, quantitative data were obtained by taking a picture with a smartphone camera and measuring the color intensity using ImageJ software. A comparison between BTB and phenol red as pH indicators revealed that the former afforded better results in terms of resolution. Under optimal conditions, good linear responses of blue intensity were obtained in a concentration range of 0.10%–1.0% (w/w). The recovery was determined to range between 98.1% and 118.3% with a relative standard deviation of <5%. The developed paper strip assay was applied to determine urea in animal protein and fishmeal, finding good agreement with the official AOAC method (No. 967.07). The present paper strip is rapid and requires neither sophisticated devices nor skilled personnel, allowing its use by quality controllers for the routine on‐site detection of the urea adulteration of raw materials. [ABSTRACT FROM AUTHOR]

This article discusses a literature search that was conducted to identify the top 100 cited papers in cutaneous lupus erythematosus (CLE). CLE is a subset of lupus erythematosus characterized by autoimmune-mediated skin manifestations. The search yielded 5750 articles, and the top 100 most cited articles were categorized into basic science research, clinical research, or new treatment categories. The majority of the top cited articles were clinical research articles, indicating their impact on research and clinical practice. The findings reveal important contributions to understanding CLE's pathogenesis, epidemiology, and management, providing valuable insights for researchers, clinicians, and funders in the field of autoimmune skin disorders. [Extracted from the article]

The CP phenotype for each cohort was scored on the following criteria as either high confidence (fulfilled >=5 criteria), moderate (3-4), or low confidence (<=2): (i) CP defined with well acknowledged definition; (ii) clinical diagnosis of CP confirmed at time of recruitment; (iii) inclusion/exclusion criteria of the study met the clinical description of CP; (iv) CP clinically confirmed at >= age four; (v) motor disorders of CP well described; (vi) individual phenotyping data available. B Results b : Among the sample of children, 30 did not have CP and 45 had spastic CP (GMFCS levels I-V; 29 bilateral CP; 16 unilateral CP: 8 right, 8 left). B Background and Objective(s) b : The compounding effects of adverse health/function factors as individuals with cerebral palsy (CP) age into and through adulthood can create multiple pathways to complex medical profiles, but the patterns of comorbidities among adults with CP remains understudied. B Background and Objective(s) b : Cerebral palsy (CP) results in impairment of muscle function including muscles of the face, mouth, and throat, which may cause oropharyngeal dysphagia (OPD) and affects 85% of children with CP. B Background and Objective(s) b : The QEDIN-CP network provides training and support for early screening to fast-track infants to early intervention according to the cerebral palsy (CP) early detection guideline. [Extracted from the article]

Women using antiseizure medication in pregnancy are often advised to use high doses of folic acid supplements (1mg to 5 mg) to reduce the risk of teratogenicity. Recently, we published a report showing an association between maternal prescription fill of high dose folic acid in relation to pregnancy and childhood cancer in the offspring. The report has sparked a debate about which dose of folic acid that should be recommended in pregnancy in women in need of antiseizure medication. In this Commentary, we explain our findings and the method used in our report, and answer recent questions that have emerged. [ABSTRACT FROM AUTHOR]

Key points: Web‐based references form an integral part of academic culture and literature, as well as scientific communication.The preservation of web‐based references that are cited in‐text or in reference lists of academic papers is essential to ensure the integrity of knowledge preservation.When access or links to web‐based resources and references disappear, or if they are dysfunctional, these phenomena are collectively referred to as reference rot.Even though reference rot degrades the integrity of information in academic papers, no industry‐wide solutions currently exist.Given its prominence, we propose the Internet Archive as a possible solution to address reference rot, but also note its weaknesses and limitations. [ABSTRACT FROM AUTHOR]

The insulation paper is a crucial factor for evaluating the insulation status of transformers. The traditional evaluation methods for insulation paper are dissolved gas component content analysis (CO and CO2) and furfural (2‐FAL) content analysis in oil. The detection principle of the former leads to its low accuracy, while the field application effect of the latter is not ideal due to the easy oxidation of furfural and low content. Methanol, result of its good stability and high production compared with other marker products (CO, CO2, 2‐FAL) has been investigated as a novel marker for aging evaluation of transformer insulating paper in recent years. The results of the investigation indicated that there is a good correlation between the content of methanol in oil and the degree of polymerization under laboratory conditions, which reflected the insulation aging state of the transformer insulating paper more accurately. This paper summarizes the current research status of methanol formation mechanism, detection methods and aging evaluation in insulating oil, and points out the key problems to be solved and development prospects, hoping to provide relevant reference for aging evaluation of oil immersed power transformer. [ABSTRACT FROM AUTHOR]

The high uncertainty around the COVID‐19 pandemic elicited an unprecedented level of panic buying during the early months. Using the framework of stress and coping, the current study conceptualized and tested a theoretical model that predicts individuals' panic buying in two countries. A survey of US (n = 311) and Korean consumers (n = 347) revealed that negative emotions (loneliness and anxiety) contributed to panic buying, yet two important coping resources, resilience and social support, were effective in protecting consumers from engaging in a maladaptive coping strategy. The hypothesis that collectivism (vs. individualism) would make consumers rely on social (vs. personal) coping resources was partially supported. The results highlight the unique circumstance of the global pandemic in which social support works as both a resource for healthy coping and a source to increase negative emotions, and call for future investigation of the complex role of social support in the context of stress and coping theory. [ABSTRACT FROM AUTHOR]

The conversion of ubiquitous hygrothermal resources into renewable energy offers significant potential for cable‐free, self‐powered systems that can operate worldwide without regard to climatic or geographic limitations. Here, an all‐printed flexible hygro‐thermoelectric paper generator is demonstrated that uses bifunctional mobile ions and electrons to make the moist‐diffusion effect, the Soret effect, and the Seebeck effect work synergistically. In the ordinary hygrothermal settings, it generates an unconventional hygro‐thermoelectric output pattern and shows almost a dozen‐fold increase in positive hygro‐thermopower of 26.70 mV K−1 and also another negative hygro‐thermopower of −15.71 mV K−1 compared to pure thermopower. A single paper generator can produce a giant 680 mV displaying typical cyclic sinusoidal waveform characters with volt‐sized amplitudes. The ion‐electron conductive ink is easily printable and consists primarily of a Bi2Te3/PEDOT:PSS thermoelectric matrix modulated with a hygroscopic glycerol that releases ion charges for moist‐diffusion effect and Soret effect, as well as electron charges for Seebeck effect. The emerged hygro‐thermoelectric harvesting strategy from surrounding hygrothermal resources offers a revolutionary approach to the next generation of hybrid energy with cost‐efficiency, flexibility, and sustainability, and also enables large‐scale roll‐to‐roll production. [ABSTRACT FROM AUTHOR]

TiO2 nanoparticles can improve the electrical performance of oil paper insulation. In this study, 10 nm TiO2 nanoparticles were prepared and dispersed into transformer oil, and then immerse pressboards in it to obtain nanofluid impregnated pressboards (NP). Its thermal aging was accelerated together with the reference sample at 130°C for 36 days. Analyzing the acid value in the oil, polymerization degree, surface topography, AC breakdown strength, surface flashover characteristics and surface potential decay characteristics. It was observed that TiO2 nanoparticles can reduce the acid value and improve AC breakdown strength of oil. However, the degree of polymerization and surface appearance of NP and oil impregnated pressboards (OP) during thermal aging did not differ significantly. During the aging process, the energy level of pressboard surface traps shifted first towards the shallow and then gradually towards the deep. During all the aging stages, the surface flashover voltage of NP was always higher or close to that of OP. The mechanism of TiO2 nanoparticles improving the breakdown and surface flashover characteristics of oil–paper insulation during thermal aging is discussed from the perspective of water molecules and aging by‐products adsorption and introduction of shallow traps by nanoparticles. [ABSTRACT FROM AUTHOR]

Point‐of‐care testing (POCT) can be the method of choice for detecting infectious pathogens; these pathogens are responsible for not only infectious diseases such as COVID‐19, but also for certain types of cancers. For example, infections by human papillomavirus (HPV) or Helicobacter pylori (H. pylori) are the main cause of cervical and stomach cancers, respectively. COVID‐19 and many cancers are treatable with early diagnoses using POCT. A variety of nucleic acid testing have been developed for use in resource‐limited environments. However, questions like unintegrated nucleic acid extraction, open detection systems increase the risk of cross‐contamination, and dependence on expensive equipment and alternating current (AC) power supply, significantly limit the application of POCT, especially for on‐site testing. In this paper, a simple portable platform is reported capable of rapid sample‐to‐answer testing within 30 min based on recombinase polymerase amplification (RPA) at a lower temperature, to detect SARS‐CoV‐2 virus and H. pylori bacteria with a limit of detection as low as 4 × 102 copies mL−1. The platform used a battery‐powered portable reader for on‐chip one‐pot amplification and fluorescence detection, and can test for multiple (up to four) infectious pathogens simultaneously. This platform can provide an alternative method for fast and reliable on‐site diagnostic testing. [ABSTRACT FROM AUTHOR]

Objectives: Faculty development is essential for academic emergency physicians to maintain clinical skills and succeed in administrative and leadership roles and for career advancement and satisfaction. Faculty developers in emergency medicine (EM) may struggle to find shared resources to guide faculty development efforts in a way that builds on existing knowledge. We aimed to review the EM‐specific faculty development literature since 2000 and come to a consensus about the most useful for EM faculty developers. Methods: A database search was conducted on the topic of faculty development in EM from 2000 to 2020. After identifying relevant articles, we performed a modified Delphi process in three rounds, using a team of educators with a range of experiences with faculty development and education research, to identify articles that would be most useful to a broad audience of faculty developers. Results: We identified 287 potentially relevant articles on the topic of EM faculty development, 244 from the initial literature search, 42 from manual review of the references of the papers meeting inclusion criteria, and one by our study group's recommendation. Thirty‐six papers met final inclusion criteria and underwent full‐text review by our team. The Delphi process yielded six articles that were deemed most highly relevant over the three rounds. Each of these articles is described here, along with summaries and implications for faculty developers. Conclusions: We present the most useful EM papers from the past two decades for faculty developers seeking to develop, implement, or revise faculty development interventions. [ABSTRACT FROM AUTHOR]

Solar-driven photothermal water evaporation is considered an elegant and sustainable technology for freshwater production. The existing systems, however, often suffer from poor stability and biofouling issues, which severely hamper their prospects in practical applications. Conventionally, photothermal materials are deposited on the membrane supports via vacuum-assisted filtration or dip-coating methods. Nevertheless, the weak inherent material-membrane interactions frequently lead to poor durability, and the photothermal material layer can be easily peeled off from the hosting substrates or partially dissolved when immersed in water. In the present article, the discovery of the incorporation of borophene into cellulose nanofibers (CNF), enabling excellent environmental stability with a high light-to-heat conversion efficiency of 91.5% and water evaporation rate of 1.45 kg m-2 h-1 under simulated sunlight is reported. It is also demonstrated that borophene papers can be employed as an excellent active photothermal material for eliminating almost 100% of both gram-positive and gram-negative bacteria within 20 min under three sun irradiations. The result opens a new direction for the design of borophene-based papers with unique photothermal properties which can be used for the effective treatment of a wide range of wastewaters. [ABSTRACT FROM AUTHOR]

Due to migration, terror‐threats and the viral pandemic, various EU member states have re‐established internal border control or even closed their borders. European Association for Biometrics (EAB), a non‐profit organisation, solicited the views of its members on ways which biometric technologies and services may be used to help with re‐establishing open borders within the Schengen area while at the same time mitigating any adverse effects. From the responses received, this position paper was composed to identify ideas to re‐establish free travel between the member states in the Schengen area. The paper covers the contending needs for security, open borders and fundamental rights as well as legal constraints that any technological solution must consider. A range of specific technologies for direct biometric recognition alongside complementary measures are outlined. The interrelated issues of ethical and societal considerations are also highlighted. Provided a holistic approach is adopted, it may be possible to reach a more optimal trade‐off with regards to open borders while maintaining a high‐level of security and protection of fundamental rights. European Association for Biometrics and its members can play an important role in fostering a shared understanding of security and mobility challenges and their solutions. [ABSTRACT FROM AUTHOR]

Environmental sustainability is a huge challenge in Africa as the region is currently struggling to provide sustainable systems to support daily human activities. Such activities in many African organisations include paper‐based information storage and communication which are not ecofriendly and place a huge burden on forest resources. This study therefore focused on the implication of overusing paper in an African university. Fifty offices in the university were surveyed and 59 questionnaires administered. The questionnaires were transcribed and analysed using both textual qualitative and quantitative analyses. The results showed that 6888 reams of paper (costing about 8 million Naira) are consumed annually by the university, translating to about 413 trees, which are enough to occupy a standard‐sized football pitch. It was also found that administrative staff members were generally Information Communication Technology (ICT) certified; however, many of them are still not well‐informed on the environmental implication of overconsuming paper even though they are largely aware of the benefits of paperless systems. Recommendations were offered on how to reduce the demand for paper by the university. This study is expected to create more awareness on the urgent need for African organisations to take environmental sustainability issues more seriously. [ABSTRACT FROM AUTHOR]

The small‐signal dielectric and piezoelectric coefficients of paper‐derived sodium potassium niobate, K0.5Na0.5NbO3 (KNN), were compared with those of conventionally prepared samples. Results show similar functional properties of paper‐derived KNN without significantly decreasing the small‐signal piezoelectric coefficient. The structure and microstructure analysis of conventional KNN and paper‐derived KNN did not reveal any significant difference in the crystal structure and grain size. However, the temperature‐dependent inter‐ferroelectric phase transition temperature estimated from the temperature‐dependent dielectric permittivity data revealed a decrease of approximately 18°C for the paper‐derived KNN and is possibly associated with the structural and microstructural defects. This work indicates that optimizing suspension chemistry and sintering conditions will be critical to enhance the functional response of paper‐derived KNN further. Moreover, paper‐derived ceramic processing, a novel and cost‐effective additive manufacturing technology, can be potentially used to fabricate other electroceramics with a wide range of porosities and sizes as well as complex geometries and multilayer structures. [ABSTRACT FROM AUTHOR]

Optimal foraging theory predicts that well‐defended potential foods should be exploited only when energy pay‐offs are great. Although stinging hymenopteran nests are both well‐defended and predated by primates, their larvae's energy yields rarely have been calculated, and predation‐linked foraging behaviours by primates infrequently documented. Based on 58 opportunistic observations of primates raiding wasp nests for larvae, we calculated energetic yields of low‐ and high‐risk wasp nest predation for Cebus albifrons, Saimiri collinsi, S. sciureus and Sapajus apella, and tested predictions derived from optimal foraging theory. We recorded how nests were processed and by which age‐sex classes, eaten nest fragment sizes, number of occupied and empty cells, and nest occupancy patterns (percent larvae/pupae, eggs, empty cells). Basal metabolic rate (BMR) calculations showed energetic yields from 15 min foraging on low‐risk nests (Polybia quadricincta) would meet energy needed to sustain adult female and male C. albifrons BMR for 4.9 and 4.5 h, respectively; yields from high‐risk (Chartergus artifex) nests for 6.5 and 6.2 h; Mischocyttarus sp. nest yields (low risk, but mimetically resembling other wasps) would meet S. collinsi BMR for 2.9 h (female) and 2.3 h (male), and 2.6 and 2.1 h, for the slightly larger S. sciureus, respectively. The Chartergus energetic‐yield value is nearly 20% of a 36 g chocolate bar (741 kJ). Our data provide quantitative support for the common assertion that wasp larvae and pupae are high‐yield foods for primates. As predicted by optimal foraging, energetic yield is sufficient to offset the risk and pain of being stung. [ABSTRACT FROM AUTHOR]

Different on‐chip antennas in Complementary Metal‐Oxide‐Semiconductor (CMOS) technology for THz detector and source are proposed. Firstly, the size of these antennas is estimated with an equivalent CMOS substrate model. Finally, through electromagnetic simulation, the structure optimised and slotted the on‐chip antenna to realise multi‐band detection, miniaturised detection, and miniaturised source. For the THz detector, multi‐band antennas with a dual‐ring structure and miniaturised antennas with circular and diamond structures are designed. At the frequency of 300, 600, and 800 GHz, the gain of the ring antennas is 5.7, 7.2, and 7.2 dBi, respectively. The gain of the circular and diamond antenna is 5.3 and 5.96 dBi at 300 GHz. For the THz source, rectangular‐slot and T‐slot antennas are designed at the frequency of 300 GHz and the gain of the rectangular‐slot and T‐slot antennas is 2.92 and 3.87 dBi, respectively. Multi‐band antennas and miniaturised antennas effectively save the occupation area and improve the performance of the THz system. The effectiveness of antennas is verified by the measurement of the detector and the source, which indicates that the proposed on‐chip antennas have potential prospects for CMOS THz applications. [ABSTRACT FROM AUTHOR]

Among plastic items, single‐use straws are particularly detrimental to marine ecosystems because such straws, including those made of poly(lactic acid) (PLA), are sharp and extremely slowly degradable in the ocean. While paper straws are promising alternatives, they exhibit hydration‐induced swelling even when coated with a non‐degradable plastic coating and promote effervescence (fizzing) in soft drinks owing to their surface heterogeneities. In this study, upgraded paper straw is coated with poly(butylene succinate) cellulose nanocrystal (PBS/CNC) composites. CNC increases adhesion to paper owing to their similar chemical structures, optimizes crystalline PBS spherulites through effective nucleation, and reinforces the matrix through its anisotropic and rigid features. The straws are not only anti‐fizzing when used with soft drinks owing to their homogeneous and seamless surface coatings, but also highly water‐resistant and tough owing to their watertight surfaces. All degradable components effectively decompose under aerobic composting and in the marine environment. This technology contributes to United Nations Sustainable Development Goal 14 (Life Below Water). [ABSTRACT FROM AUTHOR]

Despite the ever‐increasing demand for transparent power sources in wireless optoelectronics, most of them have still relied on synthetic chemicals, thus limiting their versatile applications. Here, a class of transparent nanocellulose paper microsupercapacitors (TNP‐MSCs) as a beyond‐synthetic‐material strategy is demonstrated. Onto semi‐interpenetrating polymer network‐structured, thiol‐modified transparent nanocellulose paper, a thin layer of silver nanowire and a conducting polymer (chosen as a pseudocapacitive electrode material) are consecutively introduced through microscale‐patterned masks (which are fabricated by electrohydrodynamic jet printing) to produce a transparent conductive electrode (TNP‐TCE) with planar interdigitated structure. This TNP‐TCE, in combination with solid‐state gel electrolytes, enables on‐demand (in‐series/in‐parallel) cell configurations in a single body of TNP‐MSC. Driven by this structural uniqueness and scalable microfabrication, the TNP‐MSC exhibits improvements in optical transparency (T = 85%), areal capacitance (0.24 mF cm−2), controllable voltage (7.2 V per cell), and mechanical flexibility (origami airplane), which exceed those of previously reported transparent MSCs based on synthetic chemicals. [ABSTRACT FROM AUTHOR]

Developmental pharmacology describes the impact of maturation on drug disposition (pharmacokinetics, PK) and drug effects (pharmacodynamics, PD) throughout the paediatric age range. This paper, written by a multidisciplinary group of experts, summarizes current knowledge, and provides suggestions to pharmaceutical companies, regulatory agencies and academicians on how to incorporate the latest knowledge regarding developmental pharmacology and innovative techniques into neonatal and paediatric drug development. Biological aspects of drug absorption, distribution, metabolism and excretion throughout development are summarized. Although this area made enormous progress during the last two decades, remaining knowledge gaps were identified. Minimal risk and burden designs allow for optimally informative but minimally invasive PK sampling, while concomitant profiling of drug metabolites may provide additional insight in the unique PK behaviour in children. Furthermore, developmental PD needs to be considered during drug development, which is illustrated by disease‐ and/or target organ‐specific examples. Identifying and testing PD targets and effects in special populations, and application of age‐ and/or population‐specific assessment tools are discussed. Drug development plans also need to incorporate innovative techniques such as preclinical models to study therapeutic strategies, and shift from sequential enrolment of subgroups, to more rational designs. To stimulate appropriate research plans, illustrations of specific PK/PD‐related as well as drug safety‐related challenges during drug development are provided. The suggestions made in this joint paper of the Innovative Medicines Initiative conect4children Expert group on Developmental Pharmacology and the European Society for Developmental, Perinatal and Paediatric Pharmacology, should facilitate all those involved in drug development. [ABSTRACT FROM AUTHOR]

In order to further meet the requirements of testing applications in various fields, a simple, rapid, and low‐cost testing method is demanded for on‐site testing. Electrochemical paper‐based analytical devices (ePADs) have attracted wide attention in many practical applications due to their excellent performance. ePADs combine the benefits of easy‐to‐use, low‐cost, electrochemical sensitivity and selective detection, as well as the advanced nature of pumpless equipment. In this paper, the latest development and new trend of ePADs are reviewed. First, several preparation methods of ePADs are introduced. We then reviewed examples of their use in various fields, particularly in point‐of‐care testing. Finally, the research of ePADs is summarized and prospected. [ABSTRACT FROM AUTHOR]

This article is a guest editorial for the IET Radar, Sonar & Navigation journal, focusing on selected papers from the RADAR 2022 conference held in Edinburgh, UK. The conference provided an opportunity for radar specialists from 22 countries to explore the latest developments in radar systems. Key topics discussed at the conference included new radar trends, target detection (with a focus on drones), low-frequency radar, and cognitive radar. The special issue contains 17 papers based on extended work presented at the conference, covering topics such as multistatic radar, passive radar, target signatures, and advanced radar processing techniques. The authors hope that this special issue will serve as a valuable resource for further research in the field. [Extracted from the article]

Arc discharge in the power transformer can bring enormous economic losses and safety risks. The transformer protection system for arc discharge faults is still not ideal. The physical characteristics of the whole process from partial discharge defects transition to arc faults are not fully recognized, mainly because it is difficult to establish and sense the relevant characteristic parameters. This paper built a research platform for studying the transition process from partial discharge to early arc discharge based on fibre‐optic ultrasonic, temperature, pressure sensors with traditional electrical voltage and current sensors. Five discharge models are designed and the changing pattern of multiple parameters in the transition process of different models is studied. The experiment results show that the amplitude and frequency of acoustic waves drop significantly after the arc breakdown. Ultrasonic and high‐frequency current sensing in the early warning of arc fault each has its own limitations. The pressure caused by the arc is not only related to the arc energy but also related to the discharge types. The overall oil temperature change after the early arc discharge is small and hard to detect. This work highlights the promise of using fibre‐optic sensors for physical process research within a harsh electromagnetic environment. [ABSTRACT FROM AUTHOR]

Children frequently respond differently to therapies compared to adults. Differences also exist between paediatric age groups for pharmacokinetics and pharmacodynamics in both efficacy and safety. Paediatric pharmacovigilance requires an understanding of the unique aspects of children with regard to, for example, drug response, growth and development, clinical presentation of adverse drug reactions (ADRs), how they can be detected and population‐specific factors (e.g., more frequent use of off‐label/unlicensed drugs). In recognition of these challenges, a group of experts has been formed in the context of the conect4children (c4c) project to support paediatric drug development. This expert group collaborated to develop methodological considerations for paediatric drug safety and pharmacovigilance throughout the life‐cycle of medicinal products which are described in this article. These considerations include practical points to consider for the development of the paediatric section of the risk management plan (RMP), safety in paediatric protocol development, safety data collection and analysis. Furthermore, they describe the specific details of post‐marketing pharmacovigilance in children using, for example, spontaneous reports, electronic health care records, registries and record‐linkage, as well as the use of paediatric pharmacoepidemiology studies for risk characterisation. Next the details of the assessment of benefit–risk and challenges related to medicinal product formulation in the context of a Paediatric Investigation Plan (PIP) are presented. Finally, practical issues in paediatric signal detection and evaluation are included. This paper provides practical points to consider for paediatric pharmacovigilance throughout the life‐cycle of medicinal products for RMPs, protocol development, safety data collection and analysis and PIPs. [ABSTRACT FROM AUTHOR]

Improved global access to novel age‐appropriate formulations for paediatric subsets, either of new chemical entities or existing drugs, is a priority to ensure that medicines meet the needs of these patients. However, despite regulatory incentives, the introduction to the market of paediatric formulations still lags behind adult products. This is mainly caused by additional complexities associated with the development of acceptable age‐appropriate paediatric medicines. This position paper recommends the use of a paediatric Quality Target Product Profile as an efficient tool to facilitate early planning and decision making across all teams involved in paediatric formulation development during the children‐centric formulation design for new chemical entities, or to repurpose/reformulate off‐patent drugs. Essential key attributes of a paediatric formulation are suggested and described. Moreover, greater collaboration between formulation experts and clinical colleagues, including healthcare professionals, is advocated to lead to safe and effective, age‐appropriate medicinal products. Acceptability testing should be a secondary endpoint in paediatric clinical trials to ensure postmarketing adherence is not compromised by a lack of acceptability. Not knowing the indications and the related age groups and potential dosing regimens early enough is still a major hurdle for efficient paediatric formulation development; however, the proposed paediatric Quality Target Product Profile could be a valuable collaborative tool for planning and decision making to expedite paediatric product development, particularly for those with limited experience in developing a paediatric product. [ABSTRACT FROM AUTHOR]