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Examines the oxalate and glyoxylate synthesis in vitro using isolated guinea pig peroxisomes and purified lactose dehydrogenase. Lack of complete understanding of certain features of hepatic oxalate synthesis; Clarification of the terminal steps of the biosynthetic pathway and their modulation.

Examines the effects of glucagon on oxalate synthesis as measured from the urinary excretion of the substance. Changes in the hepatic levels of metabolites and enzymes involved in oxalate synthesis; Hormone regulation of hepatic metabolism; Correlations between oxalate and urea excretion; Hepatic enzymes and metabolites; Peroxisomes.

Examines oxalate and glyoxylate synthesis in vivo using isolated guinea pig peroxisomes and purified lactate dehydrogenase. Conversion of the bulk of the glyoxylate to glycine; Enzyme assays and glycine oxidation; Effect of pH on oxalate synthesis from glycolate in isolated peroxisomes.