Search

We theoretically propose a method based on the combination of a nonlinear optical mass sensor using a hybrid spin-microcantilever and the nanoparticle-enhanced technique, to detect and monitor DNA mutations. The technique theoretically allows the mass of external particles (ssDNA) landing on the surface of a hybrid spin-microcantilever to be detected directly and accurately at 300 K with a mass responsivity 0.137 Hz/ag in situ in liquid. Moreover, combined with the nanoparticle-enhanced technique, even only one base pair mutation in the target DNA sequence can be identified in real time accurately, and the DNA hybridization reactions can be monitored quantitatively. Furthermore, in situ detection in liquid and measurement of the proposed nonlinear optical spin resonance spectra will minimize the experimental errors. [ABSTRACT FROM AUTHOR]

Motivated by recent experimental progress towards the detection and manipulation of Majorana fermions in ferromagnetic atomic chains on a superconductor, we present a novel proposal based on a single-crystal diamond (SCD) microcantilever with a single nitrogen-vacancy (NV) center spin embedded in ultrapure diamond substrate to probe Majorana fermions in an all-optical domain. With this scheme, a possible distinct Majorana signature is investigated via the electron spin resonance spectrum. In the proposal, the SCD microcantilever behaves as a phonon cavity and is robust for detecting of Majorana fermions, while the NV center spin can be considered as a sensitive probe. Further, the vibration of the microcantilever will enhance the coupling effect, which makes the Majorana fermions more sensitive to detection and the well-established optical NV spin readout technology will certainly promote the detection. This proposed method may provide a potential supplement for the detection of Majorana fermions. [ABSTRACT FROM AUTHOR]

Nowadays hybrid spin-micro/nanomechanical systems are being actively explored for potential quantum sensing applications. In combination with the pump-probe technique or the spin resonance spectrum, we theoretically propose a realistic, feasible, and an exact way to measure the cantilever frequency in a hybrid spin-micromechanical cantilever system which has a strong coherent coupling of a single nitrogen vacancy center in the single-crystal diamond cantilever with the microcantilever. The probe absorption spectrum which exhibits new features such as mechanically induced three-photon resonance and ac Stark effect is obtained. Simultaneously, we further develop this hybrid spin-micromechanical system to be an ultrasensitive mass sensor, which can be operated at 300 K with a mass responsivity 0.137 Hz ag−1, for accurate sensing of gaseous or aqueous environments, chemical vapors, and biomolecules. And the best performance on the minimum detectable mass can be in vacuum. Finally, we illustrate an in situ measurement to detect Angiopoietin-1, a marker of tumor angiogenesis, accurately with this hybrid microcantilever at room temperature. [ABSTRACT FROM AUTHOR]