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Marathon performance is influenced by factors such as aerobic capacity and those related to neuromuscular function. Complex training (CPX) is a multicomponent training method, wherein heavy strength and plyometric exercises alternate within a single session and is an effective method to improve neuromuscular adaptations. This study compared the effects of CPX, heavy strength training (HST) and endurance-strength (EST) combined with running endurance training on neuromuscular adaptations and running performance in 38 recreational marathoners (age:31.4 ± 3.8 years, VO2max:57.6 ± 6.8 ml·kg−1·min−1). Athletes were allocated in 3 groups: CPX, HST and EST and were tested for one maximum repetition strength (1RM), squat jump and countermovement jumps (SJ, CMJ), leg press (LP) concentric and eccentric strength, running economy (RE) and velocity at VO2max (vVO2max) before and after the 6-week intervention. CPX and HST were performed 2 times per week in conjunction with the running endurance training. RE and vVO2max improved in CPX and HST groups (p < 0.01, RE: −5% to −6.4%, vVO2max: 5.7% and 4.2%, respectively) with no change in EST. Similarly, all neuromuscular performance indicators improved in CPX and HST (p < 0.0167, 1RM strength:19.7% to 25.1%, SJ and CMJ: 5.3% to 11.6%, LP concentric and eccentric strength: 5.5% to 18.0%). In summary, 6-week of concurrent CPX or HST and endurance training resulted in similar improvement in maximum strength, RE, and vVO2max. Importantly, both CPX and HST training resulted in greater improvements in eccentric strength and RE compared to EST that performed concurrent endurance-strength and endurance training. [ABSTRACT FROM AUTHOR]

Introduction: Acute myeloid leukemia (AML) patients with CEBPA double mutation (CEBPAdm) were associated with distinct immunophenotypes and prognosis. Recently, both International Consensus Classification (ICC) and World Health Organization (WHO) classifications incorporated BZIP single mutations (CEBPAsmBZIP) into the favorable risk group. However, the immunophenotypes of CEBPAsmBZIP mutations have not been characterized, especially when compared with the immunophenotypes of CEBPAdm. Methods: Retrospectively, we investigated and compared the immunophenotypes of AML with CEBPA mutations. Randomforest model and XGBoost algorithm were used to set up a scoring system based on the immunophenotypes of those patients. Results: In a total of 967 AML patients: 218 were CEBPAdm (198 consisted of mutations in the BZIP region [CEBPAdmBZIP], 20 were double mutations outside BZIP region [CEBPAdm‐woBZIP]), 117 were CEBPAsm (54 CEBPAsmBZIP and 63 were single mutations outside BZIP region [CEBPAsm‐woBZIP]) and the others were wildtype CEBPA (CEBPAwt). Patients with CEBPAdmBZIP, CEBPAdm‐woBZIP and CEBPAsmBZIP shared the distinct immunophenotype of CD7+ CD34+ MPO+ HLA‐DR+ CD19−, in contrast to patients with CEBPAsm‐woBZIP and CEBPAwt who showed reduced expression of CD7, HLA‐DR, MPO, CD34 and a higher expression of CD19. Based on these immunophenotypes, we developed a scoring system to preemptively identify AML with CEBPAsmBZIP and CEBPAdm and validated it internally and externally. Conclusions: AML with CEBPAdmBZIP, CEBPAdm‐woBZIP, and CEBPAsmBZIP shared similar immunophenotypic profiles, whereas profoundly differed from the CEBPAsm‐woBZIP and CEBPAwt AML. [ABSTRACT FROM AUTHOR]

Objectives: To compare the prevalence of chronic periodontitis between men who had semen abnormalities and those who had normozoospermia through a case–control study. Materials and Methods: Male patients who visited the assisted reproduction clinic of a large general hospital and were diagnosed with semen abnormalities were included in the case group. The control group was composed of patients of the same clinic with normozoospermia. The semen analysis included sperm concentration, count and progressive and total motility, which were measured in the laboratory. A questionnaire and clinical periodontal examination were conducted for all participants. Logistic regression was performed to explore the relationship between chronic periodontitis and male infertility. Results: A total of 192 participants were included: 63 participants (32.8%) had some type of semen abnormality (case group), while 129 participants (67.2%) had normozoospermia (control group). The case group had a significantly higher prevalence of moderate/severe periodontitis than the control group (33.3% vs. 17.8%, p =.012). The logistic regression showed that participants who had moderate/severe periodontitis had a greater chance of having semen abnormalities after adjusting for other confounding factors (OR = 3.377, p =.005). Conclusions: Periodontitis is associated with semen abnormalities and sperm motility in men. [ABSTRACT FROM AUTHOR]