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Objective To explore the therapeutic and prognosis effects of delayed thoracic drainage in the treatment of medium volume hemothorax caused by blunt trauma. Methods Forty-two patients with medium volumn of blunt trauma hemothorax were selected as the delayed group. Clinical observation was carried out first, and catheterization was performed 72 hours after diagnosis. Another 43 patients with blunt trauma medium hemothorax were treated with traditional early catheterization within 24 hours after diagnosis, and they were used as the control group. Data of gender, age, body mass index, chest volume on admission, number of rib fractures, hemoglobin (Hb), systolic blood pressure, mean arterial pressure, heart rate and the interval from injury to admission were compared between the two groups. Data of final thoracic drainage volume, oxygen saturation (SpO2) at discharge, decline level of Hb, number of days with tube, length of hospital stay, total hospitalization cost, presence of thoracic infection and atelectasis, and converted to surgery were also compared between the two groups. Results There were no significant differences in basic conditions between the two groups. Compared with the control group, the final thoracic drainage volume and Hb decreased, the days with tube, the days of hospitalization and the total hospitalization cost decreased, and SpO2 increased after hospital discharge in the delayed group (P＜0.01). No chest infection or atelectasis occurred in the delayed group. There were no cases requiring transfer to surgery in the two groups. Conclusion Delayed thoracic drainage can effectively improve the treatment and prognosis of patients with blunt traumatic medium volumn hemothorax, and reduce the medical economic burden. [ABSTRACT FROM AUTHOR]

BACKGROUND: Tissue-engineered skin has a good application prospect in promoting skin tissue wound repair and scarless healing. OBJECTIVE: To review the current research progress, application and value of tissue-engineered skin in vivo and in vitro. METHODS: A computer was used to search the relevant articles in the CNKI database and PubMed database. The Chinese and English search terms were “mesenchymal stem cells; growth factors; skin; wounds; skin repair; wound healing; regenerative medicine; tissue engineering; scaffolds”. The domestic and foreign related application articles on tissue-engineered skin construction in the treatment of skin tissue injury in recent years were checked, and the research progress of mesenchymal stem cells, growth factors, scaffold materials and dressings for new treatment methods for tissue repair was also summarized. The articles irrelevant to the subject of this article were excluded, and 78 articles were finally included for the result analysis. RESULTS AND CONCLUSION: The construction of tissue-engineered skin involves the selection of seed cells, the application of growth factors, and the combination of multiple elements of scaffold materials. Mesenchymal stem cells are one of the important sources of tissue-engineered skin seed cells. Growth factors optimize the tissue culture environment, and scaffold materials provide appropriate mechanical support. Therefore, how to select appropriate seed cells, growth factors and scaffold materials to construct tissue-engineered skin to treat wounds and speed up repair is the focus and research direction that should be explored in the future. In addition, the development of wound materials is also a new field. [ABSTRACT FROM AUTHOR]

Objective To analyze the debridement and promotion of collagenase on wounds in patients after thoracotomy through median sternotomy approach. Methods From January 2017 to August 2020, 30 patients with nonunion of incision after thoracotomy admitted in Friendship Cosmetic Plastic Surgery Hospital. All patients were divided into routine treatment group and collagenase treatment group, 15 patients in each group. The age, gender and area of wounds after debridement were recorded. The rate of debridement, wound healing time, length of stay, pain degree and satisfaction of both groups were statistically analyzed. Results The rate of debridement of collagenase treatment group was 21.56±0.70, 30.05±0.78 and 62.30±1.94 at 3, 7 and 14 days, which were significantly better than 16.58 ±0.44, 22.71 ±0.42 and 52.35 ±1.74 of routine treatment group. The differences were statistically significant between both groups (P<0.05). The wound healing time of routine treatment group was significantly longer than that of collagenase treatment group (P<0.05). The average length of stay of routine treatment group was significantly longer than that of collagenase treatment group (P<0.05). At 3, 7 and 14 days, the VAS score showed that collagenase treatment could relieve pain in the process of routine treatment. The differences were statistically significant between both groups (P<0.05). The satisfaction of collagenase treatment group was obviously higher than that of routine treatment group. Conclusion Collagenase can promote granulation tissue growth of wounds, accelerate healing, reduce pain and improve patients' satisfaction in the treatment of nonunion of incision after thoracotomy through median sternotomy approach. [ABSTRACT FROM AUTHOR]

Objective To explore the efficacy of plastic suture technique in the emergency surgical treatment of superficial facial trauma. Methods The clinical data of patients with superficial facial trauma underwent plastic suture technique treatment from January 2012 to January 2018 were retrospectively reviewed. Preoperative, seventh-day and sixth-month postoperative photographs were taken. The baseline information, type of trauma, location, length and depth of wounds, details of operative procedures, complications, appearance of scars and patients' satisfaction were recorded. Results A total of 720 patients were included in this study. The age of patients ranged from 2 to 76-year-old, with an average of 17.89-year-old. The follow-up period ranged from 6 to 11 months, with an average of (8.15± 3.21) months. The types of trauma were laceration (93.75%), contusion (2.50%), animal bite wounds (1.25%), human bite wounds (0.42%) and other wounds (2.08%). The forehead (20%), eyebrow and upper eyelid (20%), mandible and chin (20%) were the most common injury locations, followed by lip (15%), cheek (10%), nose (5%), temporal region (5%) and other parts (5%). The average length of wounds was (3.25±2.17) cm. The wounds of forehead and chin were deep to bony surface and other parts were deep to subcutaneous layer. The incidence rate of complications was 0.30%. The postoperative scar was not obvious in most patients. The efficacy was satisfactory. Conclusion The application of plastic suture technique in the treatment of emergency facial trauma could obtain good function and aesthetic effect. The postoperative complications are rare and the scars are not obvious. Patients' satisfaction is high. [ABSTRACT FROM AUTHOR]

Objective To explore the effect of platelet rich fibrin （PRF）in the promotion of wound healing. Methods From June 2015 to October 2019, 30 patients with wounds were selected. All patients were divided into PRF treatment group and conventional dressing change group. All patients were followed up for 6 to 12 months after discharge. The treatment time, pain degree, satisfaction, total hospitalization expenses and complications of patients were recorded. Results In the PRF treatment group, the average treatment time were（20.53±12.69）days, the average frequency of dressing change were (3.76±1.66), the average treatment expenses were（19035.29±3993.07）yuan and the scores of pain were（3.01±1.63）. In the conventional dressing change group, the average treatment time（32.85±11.47）days, the average frequency of dressing change were（15.29±4.32）and the average treatment expenses were（25946.3±9425.1）yuan. Compared with the conventional dressing change group, the application of PRF can promote wound healing, reduce the frequency of dressing change, decrease the expenses of treatment and alleviate the pain during the therapeutic process. Conclusion The application of PRF is superior to the conventional dressing change in preventing wounds infection, shortening the treatment time, alleviating the pain and decreasing the expenses. The PRF has better therapeutic effect in the treatment of complex wounds. [ABSTRACT FROM AUTHOR]

BACKGROUND: Since human embryonic stem cells were successfully obtained in 1998, clinicians have been trying to use stem cells in wound healing. Importantly, stem cells can regulate wound inflammation. OBJECTIVE: To investigate the application and prospect of adipose-derived stem cells in wound inflammation. METHODS: The first author searched CNKI and PubMed databases (from 1999 to October 2018) with the retrieval words of “adipose-derived stem cells, wound, inflammation” in Chinese and English, respectively. Literatures regarding adipose-derived stem cells, wound and inflammation were selected. The articles published lately or authoritatively in the same field were preferred. RESULTS AND CONCLUSION: Wound healing is a complex and orderly process, and closely related to wound inflammation. With the development of regenerative medicine, the application of stem cells brings a new approach to wound healing. Adipose-derived stem cells have a promising prospect as characterized by the strong abilities of proliferation and multidirectional differentiation, easy to obtain, and abundant sources. To date, adipose-derived stem cells are still one of the most popular candidates for regulating wound inflammation and promoting wound healing. [ABSTRACT FROM AUTHOR]