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Objective To understand the status quo of infectious disease reports automatically exchanged by secondary and above medical institutions in Sichuan province based on regional platform, and provide basis for improving the work on automatic exchange of infectious disease information reports in the next step. Methods Check and calculate the success rates of exchange and rough exchange through the system, the use of the infectious disease reporting management related systems was investigated by questionnaire survey, T - test and chi - square test were used for comparison between groups, and spearman correlation analysis was used for correlation. Results From July to September 2023, the exchange success rate in 68 medical institutions was 92. 67%, and the success rate of crude exchange reached 95. 87%. Compared with other level medical institutions, municipal medical institutions had higher success rate of exchange and crude exchange, and longer time interval to realize automatic exchange. The exchange success rate was positively correlated with the time interval to realize automatic exchange (r = 0. 44, P < 0. 001) and the crude exchange success rate (r = 0. 51, P < 0. 001). More than 90% of the institutions had HIS, LIS, PACS. 77. 94% of the institutions could automatically generate the report card, more than 80% had the report card management and information statistics query functions. 73. 53% realized the automatic early warning of infectious disease report card, and 25% of the institutions reported the card forcibly after the early warning. 88. 24% felt that the workload of infectious disease report was reduced after automatic exchange. Conclusion The success rate of automatic exchange and the success rate of crude exchange in medical institutions were higher overall, municipal medical institutions were higher than other levels of medical institutions. The construction rate of basic information system in medical institutions was high, but the basic functions of automatic exchange were not perfect. Automatic exchange improves the efficiency of reporting to some extent, but it still could not completely replace manual reporting. [ABSTRACT FROM AUTHOR]

Aldosterone is a kind of steroid hormone produced by the zona glomerulosa (ZG) cells of the adrenal cortex which plays a crucial regulatory role in fluid-electrolyte balance and blood pressure stability. Aldosterone biosynthesis is a calcium-dependent process, and ion channels play a key role in this process. Primary aldosteronism is closely related to mutations in ion channels. Recent studies have highlighted an intriguing relationship between the unique rosette structure of ZG cells and their electrical excitability. Elucidating the connection between rosettes and ZG cell electrical excitability as well as aldosterone secretion leads to a deeper understanding of the mechanisms regulating aldosterone secretion and may provide new insights into the pathogenesis of primary aldosteronism. [ABSTRACT FROM AUTHOR]

目的 探讨并发重度肢体缺血性坏疽伴感染的下肢动脉硬化闭塞症 (ASD) 患者血管腔内介入术后截肢 的影响因素, 构建术后截肢风险预测模型。方法　选择行血管腔内介入术治疗的 106 例 ASD 并发重度肢体缺血性 坏疽伴感染患者, 根据术后是否截肢分为截肢组 20 例和非截肢组 86 例。收集患者临床资料、感染严重程度、感染病 原菌分布、实验室指标等。采用多因素 Logistic 回归分析影响患者截肢的因素, 根据筛选出的危险因素和回归系数 建立风险预测模型, 并采用 ROC 曲线分析该模型对患者术后截肢的预测价值。结果　截肢组年龄、ABI 及合并糖尿 病、卢瑟福6级、吸烟史比例高于非截肢组 (P均<0.05)。截肢组重度感染比例高于非截肢组 (P<0.05)。106 份样本 中共检出 148 株病原菌, 其中截肢组检出34株病原菌, 以奇异变形菌、大肠埃希菌比例最高; 非截肢组检出 114 株病 原菌, 以铜绿假单胞菌、金黄色葡萄球菌比例最高。截肢组 WBC、NLR、PLR、CRP、PCT 高于非截肢组, Alb、Hb 低于 非截肢组 (P均<0.05)。多因素 Logistic 回归分析显示, 合并糖尿病、卢瑟福分级为6级、重度感染、ABI 低、病原菌为 奇异变形菌、Alb 及 Hb 水平降低是 ASD 并发足部重度肢体缺血性坏疽伴感染患者截肢的危险因素 (P均<0.05)。以 上述危险因素构建的预测模型为: 0.865+0.860×糖尿病+1.651×卢瑟福 6 级+1.296×重度感染-1.308×ABI+1.607× 奇异变形菌-1.153×Alb-1.183×Hb, 该模型预测术后截肢的曲线下面积为 0.904 (0.824～0.982), 灵敏度为 94.0%, 特异度为 87.4%。结论 并发重度肢体缺血性坏疽伴感染的 ASD 患者血管腔内介入术后仍有较高截肢率, 糖尿 病、重度感染、ABI<0.52、奇异变形菌等会增加术后截肢风险, 以上述危险因素构建的预测模型对并发重度肢体缺 血性坏疽伴感染的 ASD 患者血管腔内介入术后截肢有较高的预测价值。 [ABSTRACT FROM AUTHOR]