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Objective The study was aimed to detect bone marrow minimal residual disease (MRD) and regulatory T cell (Treg) in newly diagnosed acute leukemia (AL) and after chemotherapy, and analyze the relationship between Treg with MRD. Methods 53 cases of specimens in patients with acute leukemia were collected, and MRD and Treg were detected by multiparameter flow cytometry (FCM). From the beginning of induction chemotherapy by CR, every 3-6 months detection time, the relationship between Treg and MRD and expression of different treatment times/disease groups/risks were analyzed and compared. Results The expression of Treg in initial treatment AT patients was higher than in patients after chemotherapy and normal control (P < 0.01). There was no difference in the expression of Treg between group ANTE and group AFF (P > 0.05). High risk group was higher than low risk (P < 0.01), and there were no differences between high/low risk groups and intermediate risk group (P > 0.05). AL patients with MRD positive had a higher rate of recurrence than MRD negative patients (P < 0.01), expression of Treg in MRD positive patients was higher than that in MRD negative patients (P < 0.01). Conclusion Treg could increase in newly diagnosed leukemia patients, and it has a the higher expression when the higher grade malignancy. Treg will fall after chemotherapy and close to the normal, expression of Treg in MRD positive patient is higher than MRD negative patients. Perhaps, Treg could suppress the body immune killer for tumor cells, which has clinical significance on the prognosis, evaluation, recurrence and treatment of AL patients. [ABSTRACT FROM AUTHOR]

The authors have put forward an improved approach for project buffer sizing based on the resource constrains, logical complexity as well as project managers' risk preference by using fuzzy logic theory. Taking resource substitutability into consideration, the authors have integrated the optimization and tradeoff between cost and schedule into the indicators for the evaluation of critical chain scheduling. By means of experimental study, the new approach has been verified to be more effective and efficient than the traditional C&PM and RSEM approach. [ABSTRACT FROM AUTHOR]

Following the definition of the critical chain and its parameters in the schedule of random network, the authors have put forward the methodology on how to identify the critical chain of random network. Furthermore, the scope of the application of this methodology has also been clarified. Finally, the authors have set up the main steps of identifying the critical chain of random network. An example has also been given to show how to use this method. [ABSTRACT FROM AUTHOR]

Based on latest drilling data, outcrop geologic survey around the area and laboratory test results of lots of rock samples, analysed shale gas generation conditions and potential of Silurian Longmaxi shale in south of Sichuan Basin with the regional distribution, organic geochemical and reservoir characteristics, gas concentration and reservoir pressure of organic-rich shale rock. Through integrated study, it is thought that: Silurian Longmaxi Formation in the study area features high organic content (TOC:0.35% ~ 18.40% , average of 2.52% ) , high net shale thickness(20 260 m) ,high brittle mineral content (more than 40% -70% ) , lots of nanoporosity in organic and high gas content (0.3 ~ 5.1 m³/t,average of 1.9 m³/t), Moderate burial depth (2 000 ~ 3 600 m) is favour of the generation and accumulation of shale gas. Silurian Longmaxi Formation is one of the favorable stratas of shale gas exploration and development in China ,that accessed frequently gas show in drilling processes and obtained industrialization breakthrough; areas of Weiyuan, Longchang-Yongchuan and Changning-Gongxian are three realistic and favorable targets for Silurian Longmaxi shale gas exploration and development. [ABSTRACT FROM AUTHOR]