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Objective To explore the impact of cytomegalovirus (CMV) infection on the prognosis of Kasai operation in children with biliary atresia (BA). Methods From January 2018 to December 2020, 91 BA children undergoing Kasai operation at Tianjin Children's Hospital and Shanxi Children's Hospital were divided into two groups of CMV positive (n=35) and CMV negative (n=56).CMV positive children were divided into antiviral treatment and non-treated groups. Follow-ups were conducted for (2-34) months until October 10, 2021.The impact of CMV infection on jaundice clearance, cholangitis and autologous liver survival after Kasai operation were examined. Results In CMV positive group, there were 26 cases in treatment group and 9 cases in non-treated group. Operative age was significantly older in positive group. Significant difference existed in proportion of white blood cell (WBC).In positive group, aspartate aminotransferase (AST) spiked sharply[244.00(195.00, 341.00) vs. 185.00(126.25, 281.00), P < 0.05].No significant difference existed in jaundice clearance rate, incidence of cholangitis or survival of autologous liver after Kasai operation. The incidence rate of early cholangitis declined markedly after antiviral treatment(11.54% vs. 55.56%, P < 0.05). Conclusion CMV infection has no significant impact on the prognosis of BA children. And antiviral therapy lowers the incidence of early cholangitis. It hints that antiviral therapy has a positive effect on BA children with CMV infection. [ABSTRACT FROM AUTHOR]

Biliary atresia (BA) is a common cause of obstructive jaundice in the infantile period, and also a severe hepatobiliary disease leading to liver failure. At present, the research on the etiology and pathogenesis of BA is continuing. But various signs show that perinatal viral infection plays an important role in the occurrence and development of BA, which may be the exact cause of BA. Therefore, this paper mainly discussed the feasibility of preventing BA from the view of virus vaccination, in order to provide a new perspective for reducing the incidence of BA. [ABSTRACT FROM AUTHOR]