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For the location-routing problem of medical waste treatment centers, this paper proposed a multi-objective optimization model considering the public risk. Firstly, from the perspective of the government, the public and the processing center contractor, this paper established the mathematical model which simultaneously considered the operation cost, public risk and transportation cost.Secondly, according to the characteristics of the constructed model, this paper designed an improved multi-objective salp swarm algorithm to solve the problem. Finally, taking the planning projects of the medical waste treatment center in Chengdu, Sichuan province as an example, this paper verified the feasibility of the model and the effectiveness of the algorithm through the method of comparative analysis. [ABSTRACT FROM AUTHOR]