Search

The study was aimed to produce silver nanoparticles using catechin and Apigenin each a lone as a reducing and coverage also to investigate the anti- oxidant effects of catechin – silver nanoparticles and Apigenin silver nanoparticles on some biochemicals parameters in blood serum, Liver and kidney tissue in hydrogen peroxide – exposed rats. Scanning Electron Microscope was used to investigate the morphology and size of synthesized silver nanoparticles. (36) adults male rats were randomly and equally divided into three groups (3 rat/ group). Group (1): control group received drinking water and standard diet only, given (I) for catichin – AgNPS and (VI) for Apigenin – AgNPS. Group (2): received (%0.5H2O2) with drinking water only for 4 weeks, given (II) for catechin – Apigenin and (VII) for Apigenin - AgNPS. Group (3): received tap water and standard diet and given (50mg/kg) catechin – AgNPS, given (V) and (50mg/kg) Apigenin - AgNPS, given (X). Result showed a significant decrease (P≤0.05) in GSH level and a significant increase in MDA livel in blood serum, liver and kidney tissue of rats. The treatment with catichin – AgNPS, Apigenin - AgNPS.each a lone lead to positive effect of oxidative damage through the significant increasing (P≤0.05) in GSH level and significant decrease (P≤0.05) in MDA level in blood serum, liver and tissue of rats. [ABSTRACT FROM AUTHOR]

Gelatin is one of the most common natural macromolecules which is extensively used for preparing the nanoparticles. In the present study, type B gelatin-based nanoparticles were prepared using a twostep desolvation method and to optimize the nanoparticles, gelatin concentration, consumed acetone, temperature, and stirring speed were examined. Subsequently, vitamin D3 was encapsulated in obtained nanoparticles. Findings of the study indicated that the most optimum conditions for producing the nanoparticles with 20 mg/ml gelatin concentration were 15 ml acetone consumed volume, 40 °temperature and 1000 rpm stirring speed. The size of a produced particle under these conditions was reported as 88.6 nanometers. Also, the morphology of the obtained nanoparticle was spherical with a smooth surface which was observable through the scanning electron microscope. The size of the afore-mentioned particle increased to 177.2 nanometers followed by the addition of vitamin D3 to the produced nanoparticle which represents the encapsulation of the nanoparticle. [ABSTRACT FROM AUTHOR]