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The plant Carapa guianensis is used empirically for the treatment of dermatological diseases against inflammatory processes. The present study aimed at evaluating the healing of open skin lesions in Wistar rats treated with the C. guianensis oil. Two incisions were made on the back of the animals and the wounds were treated with the C. guianensis oil at 50% (A50) and 20% (A20). The control group (CG) received a treatment with vaseline. The wounds were treated daily and clinical, morphological and histological evaluations were performed on the fourth, seventh, 14th and 21st days of treatment and the tensiometric study on the 21st day. The biochemical profile of the animals was also assessed after 21 days of treatment. It was observed that the use of C. guianensis showed similar results to the ones of the control group in the evaluations, but in the tensiometry, the concentration A20 group presented lower tension when compared to the other groups. Regarding the biochemical parameters, the AST enzyme of the A50 group showed higher values in relation to the control group. It was possible to conclude that the C. guianensis oil shows similar results to the vaseline in wound healing, especially at a concentration of 50%. This study also showed a possible biological interference of the C. guianensis oil on the AST enzyme. [ABSTRACT FROM AUTHOR]