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Abstract: This paper compares two zooarchaeological sub-samples, each of which comes from a different area (North chamber and South chamber) of Maripe Cave Site (Santa Cruz, Argentina). In previous papers, each chamber was interpreted as a particular microenvironment based on their specific environmental and geoarchaeological features. In both areas, hunting–gatherer society occupations were recorded since the Pleistocene–Holocene transition to late Holocene. This paper investigated and discussed the different agents and processes involved in the formation of each assemblage, with the aim of assessing the taphonomic variability between the two areas and discussing their integrity. Bone specimens of Lama guanicoe (guanaco), the most common species on the site, were analyzed. The bone surfaces of specimens were studied by naked eye observations and binocular magnifying to 10×, which allowed recognition of different patterns of modification. The representation of guanaco anatomical units was also discussed at each chamber according to economic utility and BMD values. The results indicate that while there was involvement of different natural agents and processes acted differently in each sector, the main accumulating agent in both sets was human. Differences between both chambers are observed in the representation of anatomical units, in processing marks, in the conservation of specimens, and in the number and intensity performed by each natural agents and process in each sector. Each chamber indicates a different taphonomic history: the North Chamber records greater conservation and archaeological integrity, while the South Chamber shows a more complex taphonomy. [Copyright &y& Elsevier]