1. Copper-Mediated Radiofluorination of Arylstannanes with [18F]KF.
- Author
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Makaravage, Katarina J., Brooks, Allen F., Mossine, Andrew V., Sanford, Melanie S., and Scott, Peter J. H.
- Subjects
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FLUORINATION , *COPPER , *STANNANE , *RADIOACTIVE tracers , *CHEMICAL reagents , *PHENYLALANINE - Abstract
A copper-mediated nucleophilic radiofluorination of aryl- and vinylstannanes with [18F]KF is described. This method is fast, uses commercially available reagents, and is compatible with both electron-rich and electron-deficient arene substrates. This method has been applied to the manual synthesis of a variety of clinically relevant radiotracers including protected [18F]F-phenylalanine and [18F]F-DOPA. In addition, an automated synthesis of [18F]MPPF is demonstrated that delivers a clinically validated dose of 200 ± 20 mCi with a high specific activity of 2400 ± 900 Ci/mmol. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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