1. Memory B cells predict outcome in primary podocytopathies of adults.
- Author
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Bharati, Joyita, Das, Jhumki, Vignesh, Pandiarajan, Jhaveri, Kenar D, Prabhahar, Arun, Das, Chandan Krushna, Parihar, Anita Singh, Nada, Ritambhra, Ramachandran, Raja, Rawat, Amit, and Kohli, Harbir Singh
- Subjects
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IMMUNOLOGIC memory , *FOCAL segmental glomerulosclerosis , *B cells , *NEPHROTIC syndrome , *ADULTS , *AUTOBIOGRAPHICAL memory - Abstract
This article examines the role of B cells in the development and treatment of primary podocytopathies, specifically minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). The study focuses on adults with new-onset nephrotic syndrome (NS) caused by primary podocytopathy and compares them to healthy controls. The findings indicate that B cell proportions differ between children and adults, and specific B cell subsets are associated with disease activity and predict response to steroid treatment. These findings have implications for targeted therapies for primary podocytopathies. However, more research is needed to confirm these results. [Extracted from the article]
- Published
- 2023
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