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We introduce the notion of nonmalleability of a quantum state encryption scheme (in dimension d): in addition to the requirement that an adversary cannot learn information about the state, here we demand that no controlled modification of the encrypted state can be effected. We show that such a scheme is equivalent to a unitary 2-design [Dankert, et al., e-print arXiv:quant-ph/0606161], as opposed to normal encryption which is a unitary 1-design. Our other main results include a new proof of the lower bound of (d2-1)2+1 on the number of unitaries in a 2-design [Gross, et al., J. Math. Phys. 48, 052104 (2007)], which lends itself to a generalization to approximate 2-design. Furthermore, while in prime power dimension there is a unitary 2-design with ≤d5 elements, we show that there are always approximate 2-designs with O(ε-2d4 log d) elements. [ABSTRACT FROM AUTHOR]